<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22761

Description Uncharacterized protein
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSNMFDMSIPGTGSSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIGKWFVHPSSNGERVFGKSSHHASFSFAFFVHGDSTVCTSMDIREHPPVRLLTMKHLEEAQQAQQAAPGGSANGPASPSAGGVSAASGSASPNSPAVGSGAAAGSNGSTSAVAGAIEPREVILAPFGLAGTLTGQSYKASDPHTQKILDDWSAFYPISNKHSGMSSDGSDNVPPIVEILVGKVKMRYPSKYVLVADMDDWTSSGDTRSSSSSSSSTTNSSSSSSNSNSNQTTVPPTTASSIAASVLSRIHSSTERSVSGSAINSTSNQPAAPASTGSSTSAATARPKDTPGETGSSSATPSPTGTLRQRNHHKSMMNPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHAPAPASAVSNGTSGTTTTTTSTTTTGSVTIKTEPKDTNSSGSNSSGSNNTTSGIGGGDENSSGAANGVDANGNSSVWEISDPTVKASCCCIKCCKRPPSSSSSSSSSSSSSSSSSSSSTSTPSSSASSSASGRALQHQQQQHAIGAAASSSSSCSLNTVHPYSSISSPGGPGGVVGAGSGGLIHQHSKSITYPGNGSSRIDKSQYNHYHHHGVGGVGSGQSAKDHHHHHHHHHHHRPQRIAFHKRPPQEALFRPGTKPISLSAAAALAAAAAAAAANATRTASSTAGNATASSPGAVSSGDSAADSLELADSCLRSNQNCAANSGSGGGGASNTTGSAAGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPSTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGVSGGSTGGGNTTEGGQQQQQTQTGSGLSSGSSSSGSNSSSGNSALKASPRSSLSSSVIGSLKVRSESSLGASSGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQTLKRPSLFCKDYETLQSEDIPSTSHLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMSTGFGGSNVAGMPGGNSASGGSTNGMLMKGAAEASDALAEALSGGGGRSGNGGACDSAASNNGGCPPMLGQIKMELGCDGSGGGVQGAAGAGIGSANGGTPDRNGATAGNGEGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPHPNSSPGGGGCLSDGGIAIDTLVDLQMSLSSGTGSGAGSGNVSVIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPTLPSQQVMPPIPTSTVANLVYKSTRQKQKEKAAAEREKQKLREQAEREREQQQQQDQQQNAQSESSTQSTGGSGPPGGGINPPVGGIGLGLLPIIKPEVGGLTVPQPLSTPNSLLGGLNNLNGSLNHPYSNPPSQGAQSQPHSRPPSVNSLPGGIIGSGAGMLSPSPAGAGTSGGLFHPGMGGIPVPLRQGMSPISPATPGGSMRVPTPQGSCPLPYPSPLGGAGSPNPMGSLNFRRTTPLLPPPPYDVAIASPANSVATPSSYHSKQYPLDGVDSGGPGSNRGPMTPSSTGGGPLGTTTTVNQPLSSTGIGCATGGNGAFGVRSSSIETNALLVNILLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTGPADTAVAATGGSGGRSKASALAHLGLGGSSSSSAFGGMLGSPALGNDKAVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKKSSLFEFLNGTAKAIKMEDAGSGGTALVSTGVGASSTAGGSDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGSLFGRGTESGAVHLLEYVDANDVISLALEQGRLQAINESKMDVEQQSPASSNALVKGGTLRGVMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQQRKNGTGSSSTSSSTGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHASSSGSSSLGGGASSSLGGGSMGQPGGNTMGQNRNDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNSVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSGEKSENTESFGKTSLKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFNVIGELDLGEDLNMVIMDGEDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2980
PositionMiddle
OrganismAnopheles epiroticus
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Diptera> Nematocera> Culicoidea> Culicidae> Anophelinae> Anopheles.
Aromaticity0.05
Grand average of hydropathy-0.437
Instability index54.48
Isoelectric point6.28
Molecular weight311378.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22761
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.66|      22|      22|     724|     745|       9
---------------------------------------------------------------------------
  724-  745 (44.01/23.90)	ITYPGNGSSRIDKSQYNHYHHH
  747-  768 (45.65/25.11)	VGGVGSGQSAKDHHHHHHHHHH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.80|      12|      22|     878|     899|      10
---------------------------------------------------------------------------
  882-  896 (19.20/11.20)	PPSY..CRNPmsiGDSH
 2386- 2399 (17.60/ 6.33)	PPSTpdSSQP...GDKA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.32|      19|      22|     909|     929|      11
---------------------------------------------------------------------------
  912-  936 (24.83/12.85)	MQPSSVsQPtSVPSGDQL..itmsPHP
  940-  964 (30.50/ 9.33)	NNPRSV.QP.STPCLDHLdkntpaPTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.34|      19|      23|     985|    1003|      14
---------------------------------------------------------------------------
  858-  878 (27.43/ 7.42)	SGSG.......GGGASNttGSAAGSTTP
 1000- 1025 (25.91/ 6.47)	EGGQqqqqtqtGSGLSS..GSSSSGSNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.23|      21|      22|    1430|    1451|      15
---------------------------------------------------------------------------
  468-  498 (27.76/ 6.42)	GSSSATPSPTGTLrqrnhhkSMMNPPltvPE
 1433- 1455 (38.47/17.02)	GSPQEEPIDDWSF.......VFLPPP.icPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     255.76|      85|     432|    2434|    2524|      16
---------------------------------------------------------------------------
 2434- 2524 (134.01/104.55)	PHIVLYIVEPFTCG.......NDSPDVERLaCLSLLRC....YS.NILNSVPDSIR...........SNISVQIisLESILElGRN.RNRLRLS....DHMRCLALSVfsQSRKYLAHM
 2863- 2975 (121.75/76.06)	PLAIGYLVSTAPTGrmpewfwSSCPHMENV.CPVFLRTalhlHSpTILQNTDDPLQqnqsstehpldSNITADV..LRYVLE.GYNlLSWLAMDsnthDRLSCLPIHV..QVLMQLYHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.19|      19|      22|    1598|    1619|      18
---------------------------------------------------------------------------
 1582- 1618 (24.62/11.65)	GlnnlngslnhpysnppsqGAQSQPHSRPPSVNSLPG
 1619- 1639 (30.57/10.45)	G................iiGSGAGMLSPSPAGAGTSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      32.52|      10|      15|    1139|    1148|      19
---------------------------------------------------------------------------
 1139- 1148 (15.85/ 9.47)	VKRMRLAAEE
 1155- 1164 (16.67/10.33)	IRNLDLYANE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.02|      33|     363|    1392|    1428|      20
---------------------------------------------------------------------------
  560-  583 (31.53/ 8.32)	.......GSVTIKT..EPKDTNSS..GSNS........SGSNN
  679-  714 (49.10/15.97)	GAAASSSSSCSLNT.VHPYSSISSpgGPGGvvG.....AGSG.
  970-  997 (31.99/ 8.58)	........SKSINA..SPYHT.PS..HPGG..GvsggsTGGGN
 1392- 1425 (51.40/20.72)	GGGCLSDGGIAIDTlVDLQMSLSS..GTGS..G.....AGSGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.34|      15|      15|    1503|    1517|      21
---------------------------------------------------------------------------
 1503- 1517 (23.77/15.44)	KQKLREQAEREREQQ
 1519- 1533 (24.57/16.24)	QQDQQQNAQSESSTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.67|      14|      15|     805|     818|      22
---------------------------------------------------------------------------
  805-  818 (20.83/ 9.97)	AAAAAANATRTASS
  823-  836 (22.84/11.83)	ATASSPGAVSSGDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.97|      11|      15|    1206|    1216|      23
---------------------------------------------------------------------------
 1206- 1216 (19.07/ 8.33)	ALAEALSGGGG
 1223- 1233 (20.91/10.00)	ACDSAASNNGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.19|      15|      15|    1282|    1296|      25
---------------------------------------------------------------------------
 1282- 1296 (23.79/14.85)	GAL.LGEHEIKKEKED
 1298- 1313 (20.40/11.54)	GSIfLTDQDLQPSIDD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.02|      12|      15|     407|     418|      27
---------------------------------------------------------------------------
  407-  418 (19.43/ 9.46)	VPPTTASSIAAS
  423-  434 (19.59/ 9.62)	IHSSTERSVSGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.93|      13|      15|    1097|    1110|      28
---------------------------------------------------------------------------
 1097- 1110 (21.48/22.60)	LQTLKRPS...LFCkDY
 1113- 1128 (19.45/12.94)	LQSEDIPStshLLY.DY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.87|      25|     433|    1693|    1719|      29
---------------------------------------------------------------------------
 1693- 1712 (33.61/14.55)	........NPMGSLNFRRTTPLLPPPPY
 1715- 1729 (18.26/ 6.80)	AIASP..aNSVAT...........PSSY
 2152- 2177 (31.00/ 9.90)	TIQGPltwRQFHRLAGRGTGQCEPQP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     190.75|      58|     251|      82|     153|      32
---------------------------------------------------------------------------
   84-  146 (95.26/75.26)	SNMFdMSIPGTGSSGSVVHPPLSLTAAKElwifWYGEEPDLTDLVAPELLNSSA.....GDKGSWENG
 1840- 1902 (95.49/43.21)	SGLY.LALPGTNWMDSVTGPADTAVAATG....GSGGRSKASALAHLGLGGSSSssafgGMLGSPALG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.85|      12|      22|    1565|    1578|      33
---------------------------------------------------------------------------
 1565- 1578 (20.29/11.34)	GGLtvPQPLSTPNS
 1588- 1599 (25.56/ 9.13)	GSL..NHPYSNPPS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22761 with Med13 domain of Kingdom Metazoa
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