<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22759

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTHQNHQTNGASLEDCHTNFFALTDLCGIRWRQLVLGERPNAAGDPLDDPVVRSYSKCLAVDILCVWRRVVAPKPKPKPEPDPSSMFDMSIPGTGNSGSVVHPPLSLTAAKELWIFWYGEEPDLTDLVAPELLNSSEAGDKGSWENGLSYECRSLLFKALHNVIERCLLSRGFVRIEQWFVHPTSNDERVFGKSSHHASFSFTFFVHGDSTVITAMDIREHPPVRLLTMKHLEEAQRAAAPGAAAAAAAAASTTGGPASPDGGLNGAPGCAPGSPGGSSNSAVVPADDAIEPREVLLAPFAITGTLTGQSYRASDPHTQKILDDWSAFYPITNKHSGLADGADSMPPLVEVLVGKMKMRYPSKYVLVPDMDDWTTTTSNTINTTSNQTAGSSSSNAAAAASSARPKDTANDAAAPSPTGTLRQRNHHKSMMTPPLTVPESPSNDLGNPLSMSSALINKSPAVILPERVWQDCIMHASTPAATAASSAGSGTTATTQTSAPGSVTIKTEPKDNTSGSNSSTNNNNNNNSSNSSSGGGDENSSGAANGVDANGNSSVWEISDPTVKVSCCCIKCCKRPPSSSSSSSSSSASSSASGRTQQQQQQHTIGAAGSSSANATGGSNYASISSPGGGGAAAAGGGGSLHPHPKSSYSITYPGSSSGSSRSSHYHHHQSTKDHHHHHHHHHHRPQRVAFHKRPPQEALFRPGTEPLSLSAAAALAAAAAAAAANAASSPGAVSSGDSAADSLELADTCLRSNQNCAASSGGGGGNSGASNTTGAAPGSTTPYGGPPSYCRNPMSIGDSHPLPSEGSPASAAPSPMQPSSVSQPTSVPSGDQLITMSPHPPASNNPRSVQPGTPCLDHLDKNTPAPTPTDQHDSKSINASPYHTPSHPGGGGGGSSGGTTEGGQQQQASANLMGNSSSSSSSNSSSNGSNSSSNSSNSLSALKASPRSSLSSSGIGSLKVRSESSLGAGGSCSLGSGGGGGVPMTPSIHSVFSSAHQTAMANNLASKRESILQMLQSLKRPSLFCKDYETLQGEDIPSTSQLLYDYTCVDAWMNHPVKRMRLAAEENRLVKKIRNLDLYANEHSRTMASGPGLAGSGNSTNGGIGTNGMLMKGAAEASEALAEALSGGRSGTGGGSDNGAPNNGAGCTPLLGQIKMEIGCDGSQAGAAVGSANGGTPDRNGASAGNGGAGDGALLGEHEIKKEKEDKGSIFLTDQDLQPSIDDLNQIFDDGGPFNDDPDLHNTPPGSNKSSSGSGGFSEESKRFPSSNHHSVNSGMLSPKELSQMFPTPPSLDPQHPSSSPGGGGCLSDGGSIALDTLVDLQMSLSSGAGSGGGNGGGASSVPPIPNLGSPQEEPIDDWSFVFLPPPICPYVGSSKYAPLPSLPSQQVMPPIPTSTVAGLVYKSTRQKQKEQAAAPSSTGGSGPLGAGTVHPPLSSSGVGCGTGTPAGSRSIETNALLVNVLLYDTALNIFRDHNFKSCTLCVCNAGAKCVGNIRGADSGLYLALPGTNWMDSVTAAGAEPTPSTTPGPAGGRSKASALAHLGLGGSSSAFGAGMLGSPTVGRQEDKSAPVTINTDSLQNGYLDEDPIDCQCGFSAVVNRRMAHRAGLFYEDEMEITGMAEDPAVHKNGSLFEFLNGTAKAIKLEDADRGTLATSAGGSSSSAAGGDSLPLTLKVMDLLREQCSVVQSSSNSIHRAVNRYRGPLFGRGAENGAVHLLEYVDANDVISLALEQGRLQAINESKMDVDQQQQQQQQSSSGALVKGGTLRGQMNVHKWPFLRAGGPKSNQDIVRIMKSMQPLLQDAFHKRCTTRLWDAPYTIQGPLTWRQFHRLAGRGTGQCEPQPIPSLIVGYEKDWLSLAPYALHYWDKLLLEPYSYPRDVAYVAIVPDNDYVVAKVRTYFKELSTTYEMCKLGRHTPIKGWDGILRVGSQRVLKETQNSNLDEWFTNMGVDQQRKNGTTTAGSASSSSSSGLNELLRLYAQTCQQQLAPYLSKVPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLGGGSMGQPGGNAMGQNRPDGPGQSPMPPPPPSTPDSSQPGDKAPNTPKFDHDSENRDQLNTSSASPADGMRIDDDGKDPPHIVLYIVEPFTCGNDSPDVERLACLSLLRCYSNILNAVPDSIRSNISVQIISLESILELGRNRNRLRLSDHMRCLALSVFSQSRKYLAHMNTVKSLTGFGTAANAEQFIKRKDDKNRVPYRLYTPPYVLARSCEKSENTESFGKTSMKQQCSIMYCSYCLSEDQSWLLAVATDDRGEFLETVTINIDIPNRGRRKRASARRYGLQKLMDFILGLISQTVQPWRLVVGRIGRIGHGELKGWSWLLSKPNLQRASKHLKDICEQCSLMHPIAVPSILSACLVTLEPDSDLRVMSDQFTPDERFSQRSMQSPLSTPQDATCTHILVFPTSAKAQSAQASFSVIGELDLGEDLNMVIMDGDDDDDGINMMDVFKCWDDLPMQQINMPHSRPGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEVGLVLQQPLAIGYLVSTAPTGRMPEWFWSSCPHMENVCPVFLRTALHLHSPTILQNTDDPLQQNQSSTEHPLDSNITADVLRYVLEGYNLLSWLAMDSNTHDRLSCLPIHVQVLMQLYHMTAALA
Length2657
PositionMiddle
OrganismAnopheles coluzzii
KingdomMetazoa
Lineage
Aromaticity0.05
Grand average of hydropathy-0.445
Instability index52.34
Isoelectric point5.97
Molecular weight279193.82
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22759
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|    1400.64|     206|     214|     726|     931|       1
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  242-  382 (127.75/35.52)	.................GAA.AAA.AAA..ASTT..GGP..........A.......................S.............P.......DG.....GLNGAPGCA...P.............GSP.GGSSN.S............AVVPADD.....A...I....................EPREVLlapfaiTGT....LTGQSY......RASDP...HTQKILDD..wSAFYpiTNKHSGlADGADSMPPLVEvlVGKMK......M.R.....YPSK...........................yvlVP.................DM.DDwTTTTSNTIN
  383-  530 (139.44/39.50)	TTSN..QT...AG...SSSSNAAA.AA..........SS.............................................AR................PKDTANDAAAPSPtgtlrqrnhhksmMTP..PLTV.P............ES.PSNDlgNPLS...MSS...alinKSP.....AVILPERVW........QDCIMH..AST......PAATAASSAGSGTTAT...TQ.....TSAP......GSVTIKTE..PKD......NTS.G......SNSSTN.NN..NNNNSSN.................................................
  531-  669 (137.30/38.77)	.SSS..GG...GDENsSGAANGVD.ANG..NSSVWEISD..........P.......................TvkvscccikCCKRP..............PSSSS.......................S.SSSSS.A............SSSASGR..TQQQ...QQQ.......HTI.....GA.....................................AG...SSSANAtggSNYA..SISSPG.GGGAAAAGGGGS..LHPHPKSSYSIT.Y.....PGSSSGS.SR..SSHYHHH.................................................
  758-  973 (339.81/107.70)	AASS..GG...GGGN.SGASNTTG.AAP..GSTTPYGGP..........P.......................S.........YCRNP..MSI.GDSH..PLPSEGSPASAAPSP.............MQP.SSVSQ.P............TSVPSGD..QLIT...MSP.......HPP.....ASNNPRSVQ......PGTPCLDHLDKNT......PAPTPTDQHDSKSINA...SPYH..TPSHPG.GGGGGSSGGTTE..GGQQQQASANLM.G.....NSSSSSS.SN..SSSNGSNsssnssNS.LSalkaSPRS.SLSSS....GIGSLKVrSE.SSLGAGGSC
  974- 1161 (159.93/46.47)	SLGS..GG...GGG.....................................................................VPMTPsiHSVfSSAH..QTAMANNLASKRESI.............LQMlQSLKR.PslfckdyetlqgEDIPSTS..QLLY...DYTcvdawmnHPVkrmrlAAEENRLVK......K....IRNLD............LYANEH.SRTMAS...GP.............GLAGSGNSTN..GG..IGTNGMLMkG.....AAEASEAlAE..ALSGGRS....gtGG.GS....DNGAPNNG.......AGCTPL.LG.Q.IKMEIGC
 1162- 1329 (162.08/47.20)	DGSQ..AGaavGSAN.GGTPDRNG.ASA..GN....GGA..........GdgallgeheikkekedkgsifltD.........QDLQP...SI.DDLN..QIFDDGGPFNDDPDL.............HNT.PPGSN.K............SSSGSGG...FSE...ESK.......RFP.....SSNH.HSVN......SGMLSPKELSQMF......PTPPSLD.............PQH..PSSSPG.GGGCLSDGGSI......ALDTLVDL..........QMSLS.SG..........................................................
 1330- 1522 (183.58/54.52)	...A..GS...GGGN.GGGASSVP.PIPnlGS..PQEEPiddwsfvflpP.......................P.........IC..P..Y.V.GSSKyaPLPS.........................LP.SQ..................................QV.......MPP.....I...PTSTV......AGL.....VYKSTrqkqkeQAAAPSSTGGSGPLGA...GTVH..PPLSSS.GVGCGT..GTPA..GSRSIETNALLV.N.....VLLYDTA.LNifRDHNFKSctlcvcNAgAK....CVGNIRGADSglylALPGTNW.MD.SVTAAGAEP
 1523- 1693 (150.76/43.35)	TPSTtpGP...AGGR.SKASALAHlGLG..GSSSAFGA...................................G.........MLGSP...TV.GRQE.....DKSAPVTINTDS.............LQN.GYLDEdP............IDCQCGF..SAVVnrrMAH.......RAG.....LFYEDEMEI......TGMAEDPAVHKNG......SLFEFLN.GTAKAIKL...EDAD..RGTLAT.SAGGSSS..SAA..GGDSLPLTLKVM.DllreqCSVVQSS.SN..S.......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     686.46|     253|     504|    1819|    2138|       2
---------------------------------------------------------------------------
   67-  192 (142.50/34.92)	WRRV..VAPKPKPKPEPDPssmfdmsIPG..TGNSGSVVH.PPLSLTAAKELWIFWYGEEPDLTDL.VAPEllNSSEAGDKGSWENGLS..YE.C...RSLLFKALHNVI....ERCLLSRGFVRIEQWFVHPTSNDERVFG................................................................................................................................................................................................
 1826- 2138 (373.65/201.69)	WRQFhrLAGRGTGQCEPQP.......IPSliVGYEKDWLSlAPYALHYWDKLLLEPYSYPRDVAYVaIVPD..NDYVVAKVRTYFKELSttYEmCklgRHTPIKGWDGILrvgsQRVLKETQNSNLDEWFTNMGVDQQRKNGtttagsassssssglnellrlyaqtcqqqlaPYlSKvPSDKSLLDPPESHHHTSSSASASASLGGGAAGASSLgGGSMGQPggNAMG...QNRPDG..PG..QSPMPPPPPSTPDSSQPGDKApNTPKFDHDSENRDQLNTSSA.SPADGmRIDDDgkdpphIVLYIVEPFT....CGNDSPDVERLACLSL
 2494- 2641 (170.31/45.82)	.............................................................................................................................................................................PH.SR.PGSPSQFEGNQQSPGESGSKGAGSRDGYGSQDSEEV.GLVLQQP..LAIGylvSTAPTGrmPEwfWSSCPHMENVCPVFLRTALHL.HSPTILQNTDDPLQQNQSSTeHPLDS.NITAD......VLRYVLEGYNllswLAMDSNTHDRLSCLPI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22759 with Med13 domain of Kingdom Metazoa
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