<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22753

Description Mediator of RNA polymerase II transcription subunit 19
SequenceMSDRTSSAPFRTGPPSPSPSSPAPFNSFKDSIYSTIPPEQIPQTPTSPPLMSVSAPNDASNLANVQASSQPPSQPASLSTPPSSVPMTTQSSQQPTAGVTNSFPTPASSVDPDHMDKSFGAGFSEAGVPNTNSASVAPVQQSEHRRTDHNRDFASAEAGTGVRDFAQMGGSTQPPQGDAMELDTKTPAQTNSNWPSLESLQKDFSSAFHLCKSSHIATGPDPSVDLISLYGLGPIAKSVVRNDPVTGAKINRLRKSYEGKLKGLGLAGRNKPVKHDPSMPGGLRQMTMWPEEEWQNQKVFGKEIKVADIDSALYNMQLKAMKMEPGTVPNNDYWEDVLGHDKPAKSSAGDGPKKTPTSATAPRAVGQPNGTSMPADSERGRPSRGRKRHYDDNSFVGYGEGYADDDDDSAFYSNGEGGGKKKRKKDHVPRISAPPDRGGSYGVGMFGIGAR
Length451
PositionHead
OrganismAspergillus mulundensis
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.817
Instability index50.33
Isoelectric point7.14
Molecular weight47899.33
Publications
PubMed=30018880

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364151
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22753
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.78|      11|      31|      12|      22|       2
---------------------------------------------------------------------------
   12-   22 (23.50/ 8.57)	TGPPSPSPSSP
   35-   45 (21.60/ 7.30)	TIPPEQIPQTP
   46-   56 (20.68/ 6.70)	TSPPLMSVSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      92.72|      28|      31|      97|     127|       3
---------------------------------------------------------------------------
   97-  121 (35.33/16.97)	....AGVTNsF.P.TPASSVDP.........DHMDKSFGA
  124-  155 (21.75/ 8.69)	SEAG.......vPnTNSASVAPvqqsehrrtDH.NRDFAS
  156-  178 (35.63/11.31)	AEAGTGVRD.F.A.QMGGSTQP.........PQGD.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.85|      28|      30|     343|     370|       4
---------------------------------------------------------------------------
  343-  370 (50.20/23.25)	PAKSSAGDGPKKTPTSATAPRAVGQPNG
  374-  401 (50.65/23.53)	PADSERGRPSRGRKRHYDDNSFVGYGEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.85|      16|      31|     229|     244|       5
---------------------------------------------------------------------------
  229-  244 (29.80/16.50)	LYGLGPIAKS.VVRNDP
  261-  277 (26.05/13.56)	LKGLGLAGRNkPVKHDP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.59|      19|      37|     283|     303|       7
---------------------------------------------------------------------------
  283-  303 (33.56/26.90)	LRQMTMWP.....EEEWQNqkVFGKE
  318-  341 (31.03/18.35)	LKAMKMEPgtvpnNDYWED..VLGHD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22753 with Med19 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DDDSAFYSNGEGGGKKKRKKDHVPRISAPPDRGGSYGVGMFG
2) EPGTVPNNDYWEDVLGHDKPAKSSAGDGPKKTPTSATAPRAVGQPNGTSMPADSERGRPSRGRKRHYDDNSFVGYG
3) MSDRTSSAPFRTGPPSPSPSSPAPFNSFKDSIYSTIPPEQIPQTPTSPPLMSVSAPNDASNLANVQASSQPPSQPASLSTPPSSVPMTTQSSQQPTAGVTNSFPTPASSVDPDHMDKSFGAGFSEAGVPNTNSASVAPVQQSEHRRTDHNRDFASAEAGTGVRDFAQMGGSTQPPQGDAMELDTKTPAQTNSNWPSLE
406
324
1
447
399
198










Molecular Recognition Features






MoRF SequenceStartStop




1) YSNGEGGGKKKRKKDHVPRISAP
412
434