<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22750

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPGVIMENTSGNGSHTNHDRDSRPNGINGSSYGSDQGHEKGKGRAEPQQNMTPISPVISNGFNAHGGNGEADRFNELPPEVQHLTEGYLPLSVLLARLAQSSHSNLTAKILQLAQMPLPNPVVNGHGGSAEKPEGNTSQENLQKKIAILKFAEDMHSNWTKALVLWNWSKNAADVSKMIDLRLYLQAQQSTYNMALDSMGVLKRDLAQARVPNPDLKTALEVLSTGKASWMPELGYIEPPPLTAKELLKTLENLNTLLTIRLNLHDYDKVPYQFKEYSIKSGRVTFSVAGEFEVDLTIADEDPESQFWFIDFRFLFSPSLSELTPSTRFHIESKVNVILKEDGLQGCYKYLHELVLTHKISEFRRQAVELARGRWIDSVKVEPLNRALCIQYWLDRYGRDGPKSWIIIGVHSGRRKDGQDDPRATSRLFIRWFRESKEVQDPDISFDAVDISAEALLKAVVAKHINYILGSTYDKLKSKVLFSNNEAALSLHTSSTEPMESELKIQLSSKQHITTNIEPVSGRFTVSPASRLTFDFERTLNNRSRDPAKDAEEHIANLRCFSIAEAITSRGLSVGWQKPSPQPQISREDLKDVIPRNIVDSFLQIRWFKRPGWSSEWFVAVTLGVRGDKWWLFKTTNAATGTKVERAIEIPVKGSWASEPTFGFLSSLHIFSAALISQYTNLKALHERRIRYSLQESSKALPVRVPAIFMRLSELLPPRGSRRKPWARDVVKLIFQGLEVRSGETKVAATPAQNLSGDALPLSSAINGVSPSSQKPTSTAQGDSAVMVTEARMIIPPAGNLSVLKERVDRDIAFHAESGAFAFRLRSEIGESVVPHLVQRVSQVERLVNFAEVVHKHEKFIHSQSISLGKIVFGYDSPTQAQDRHDMMDVDSSSKYKAIVDFSSVESAMTLSLEAKNPHIRILDNLTKILNSPEGLNGVATILPLTLPALHAVDNIETAWEDLSDSGEVLILVRSTDWYIVRYNLFPADGKSRKIVLDVKLMTRRGEPWWYIRRTDHREKEGDDIDEKLKVVWNGSGAGWNGMRLSAVAEPSGVEECLGKVDEVIRKTLVQDQIPQSKPLAAPVAQMQPQAQMQPRAQMQPQAQMQPAAQMMPQAQMGQTQMQRQQQHQKLQQQRQLATPNSSQSQGRVTPNNSQNSSQGRNPSNQNSNQVRRQQPREIVEID
Length1183
PositionTail
OrganismColeophoma cylindrospora
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Leotiomycetes> Helotiales> Dermateaceae> Coleophoma.
Aromaticity0.07
Grand average of hydropathy-0.465
Instability index47.90
Isoelectric point8.66
Molecular weight132509.70
Publications
PubMed=30018880

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22750
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.14|      16|      52|      97|     113|       1
---------------------------------------------------------------------------
   97-  113 (22.96/18.87)	RLAQSSHSNLTaKILQL
  150-  165 (30.19/20.08)	KFAEDMHSNWT.KALVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     108.43|      32|      37|    1088|    1123|       2
---------------------------------------------------------------------------
 1089- 1120 (58.80/27.80)	PQAQMQPRAQMQPQAQMQPAAQMMPQAQMGQT
 1127- 1158 (49.64/27.85)	QHQKLQQQRQLATPNSSQSQGRVTPNNSQNSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.09|      40|     195|     536|     584|       3
---------------------------------------------------------------------------
  491-  531 (62.94/39.66)	LHTSSTEPM.ESELKI.QL...SSKQHITTNIEPVsGRFTVSPASR
  540-  584 (53.15/45.10)	LNNRSRDPAkDAEEHIaNLrcfSIAEAITSRGLSV.GWQKPSPQPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.49|      30|      52|       4|      33|       4
---------------------------------------------------------------------------
    4-   33 (54.01/34.87)	VIMENTSGNGSHTNHDR.DSRPNGINGSSYG
   57-   87 (48.49/30.49)	VISNGFNAHGGNGEADRfNELPPEVQHLTEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.47|      11|      37|     967|     977|       5
---------------------------------------------------------------------------
  967-  977 (18.56/11.38)	GEVLILVRSTD
 1006- 1016 (24.92/18.07)	GEPWWYIRRTD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.78|      16|      28|     918|     936|      11
---------------------------------------------------------------------------
  918-  936 (23.71/24.17)	PHIRILDNltkILNSPEGL
  948-  963 (29.06/19.76)	PALHAVDN...IETAWEDL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22750 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MPGVIMENTSGNGSHTNHDRDSRPNGINGSSYGSDQGHEKGKGRAEPQQNMTPISPVISNGFNAHGGNGEADRFNELPPEVQ
2) TLVQDQIPQSKPLAAPVAQMQPQAQMQPRAQMQPQAQMQPAAQMMPQAQMGQTQMQRQQQHQKLQQQRQLATPNSSQSQGRVTPNNSQNSSQGRNPSNQNSNQVRRQQPREIVEID
1
1068
82
1183










Molecular Recognition Features






MoRF SequenceStartStop




1) FIRWFR
429
434