<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22709

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMAAMGDDLRLDLDKLPIKRLEAIDEAGNEHYPPEEQRLAARVDFSWVVERDAKKAKKAAAEDVAHKAWPWQGLHESLQLAQQELTVVLDLISTVEANDTVAFAAISKPKPLVDEVLVDMALSAATKLQRLRHLGRYFKQSAKTMEQQFQKEAKFYGSLIRLQQNWKVKRQRGNAPGSNSFMFDVVDTSQLDTEVMPRLSSLSFVPIDQDSSGTLSVQVPQKSCRFLSLQFRGDSASGVESYTCKTKGVSSTTSSAAEDDASENDDVNKSVKQAHSTLRNIHKSIFEEQVFDMMIRETFVQTQGVNVTGMREDFLQLAIGQENLLCLSLANSGQDSDSEMAGHEEHTNSEANLVLATTNGKQEPLKSNPSGFLNPKSLEIYLLHMFHDNILKKVREKYRNIVRYQSPAHTAEPAGDECGSLGHFCMTVAHKIFSNKVQLELECVVSRVPYLHLQSLPTWHSRTSSWSICLSVPQPILAADRLMKPSDNGEPEYKSSRTQFNMKIVLKDGQISLLGEGSPSIAGSLTRKPSDGYLINSYSCDLEDLPTMVLQQVASQVINWLHEEAQVLGVSVTRDFLGLYFDLDHGDTTLGLVAQVDPDDAYGCVSWYLTVDHPAEEGKVPAVDDPWAEKCRFLGYLSLEVLHATLMDLINLCDNRRPPAEMMVEVCSSAGFVSYCAH
Length677
PositionHead
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.323
Instability index41.43
Isoelectric point5.28
Molecular weight75322.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22709
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.53|      33|      42|     361|     401|       1
---------------------------------------------------------------------------
  361-  394 (53.16/41.60)	QEPLKS.NPSGfLNPKSLEIYLLHMFHDNILKKVR
  404-  437 (56.38/26.45)	QSPAHTaEPAG.DECGSLGHFCMTVAHKIFSNKVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.66|      18|      42|     469|     486|       2
---------------------------------------------------------------------------
  469-  486 (31.98/21.08)	LSVPQPILAADRLMKPSD
  513-  530 (31.68/20.81)	LGEGSPSIAGSLTRKPSD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.82|      75|     555|      11|      91|       4
---------------------------------------------------------------------------
   11-   91 (122.33/93.68)	DLDKLPIKRLEAIDEAGNEHYPPEEQRLAARV..DF.............................SW..VVERDAKKAKKAAAEDvahkawPWQGLHESLQ.LAQQEL.TVVLDLI
  540-  649 (98.49/63.20)	DLEDLPTMVLQQVASQVINWLHEEAQVLGVSVtrDFlglyfdldhgdttlglvaqvdpddaygcvSWylTVDHPAEEGKVPAVDD......PWAEKCRFLGyLSLEVLhATLMDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22709 with Med17 domain of Kingdom Viridiplantae
Unable to open file!