<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22640

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPHPSPSPVPAVAGGGEEDGPGAPAHPAPLPAHTTEGELHVTPAATRAGEIGDASRQLNAADDVADFTLYCTGRNTGDFIKAVSLPSTLNMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTGKTSESENNQIKKELDSVNDPHLGADGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDCMGSSPCEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSEHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVRENMQGTNGQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPAALFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESARDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTMQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSAMQTESSSNSDLVPKYDMKRKESIPARLSSDADHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESVAMGDAYSFHYTGDIRESSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSASCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQPSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKEIKLNLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRSQSAMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENDSAMSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNMRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHPKSSFTKGQPGNKKQILAEQTGIEGSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQPTKEDSRHSVLSVSIVDYYGGTVQDKMSRGSKQAARHETSARDYVTDMHNVLEAVAAELHALSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1979
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.305
Instability index59.70
Isoelectric point5.71
Molecular weight215151.54
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22640
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     400.20|     117|     122|    1336|    1453|       1
---------------------------------------------------------------------------
 1271- 1338 (67.21/31.00)	LSKSWSVKSFLssLARIIKEikLNLNISTNQK.ESSNipctvVYVVCPFP.EPSAVLQ...TL.VES.........................................................................svalGSI
 1339- 1464 (187.07/103.17)	LSSERERKSFL..YAQVAKA..LNSSASADEA.SASN.....VVMLSGFS.IPKLVLQ...IVTVETLLRLHKPNELaAFKDIA....FTVYNKARRIPRFVS.TSDMFQSPTYM.SRSQSAM.MHTASPGPTLWKeclaprmsGQT
 1465- 1581 (145.91/76.16)	LSRETE...F........DA..SMRSVSWDNSwQPGR.....AVGLPDPSkIPELCAQddrKYAFEPLFILAEPGAV.DYNDTMessrFGVDASSSRVYSSISgGTDSGASPLLEgSENDSAMsLHCCYGWTEDWR...........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.79|      16|     122|     230|     248|       2
---------------------------------------------------------------------------
  230-  248 (23.26/27.17)	LRGLSYarFGDVFTKYnPP
  353-  368 (31.54/21.28)	LRGQSY..YVEVALGF.PP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.30|      22|      54|     427|     448|       3
---------------------------------------------------------------------------
  427-  448 (39.46/24.73)	VHQ.AFVRFSSKRMWSQDCMGSS
  450-  472 (33.85/19.93)	CEAwPFWNFSPSSYFRNSSFFGS
  478-  499 (33.99/20.05)	VNS.NFLRLRRQRNSNSNGMASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.68|      19|      54|     759|     777|       4
---------------------------------------------------------------------------
  759-  777 (32.06/19.61)	QSSKVESARDKSEK...SDKLT
  811-  832 (26.63/14.80)	QSCKGETSRPVSGEtsfSSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.20|      52|      54|     590|     642|       5
---------------------------------------------------------------------------
  590-  642 (88.84/54.92)	MDI.DILLSEFGdFSDF..FQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPS
  645-  699 (77.35/42.94)	MDIpEQRLSPVG.FTSMeaFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      24|      53|     947|     971|       6
---------------------------------------------------------------------------
  947-  971 (35.43/23.78)	LDSLSAKTFSgTSPSVQRQPIVELL
 1003- 1026 (45.56/26.44)	LDEQRRRGFS.CDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.08|      22|     598|    1122|    1162|       7
---------------------------------------------------------------------------
 1122- 1150 (33.55/48.28)	PQSSSDRGTseehhkgYHRVRPTIAVLPS
 1179- 1200 (41.53/15.49)	PYASAKPVT.......YYALCPDIDMLTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.94|      14|    1211|      10|      30|       8
---------------------------------------------------------------------------
    4-   17 (27.82/14.92)	PS.PSPVPAVAGGGE
   24-   38 (23.12/12.75)	PAhPAPLPAHTTEGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.26|      25|     626|     287|     315|       9
---------------------------------------------------------------------------
  291-  315 (44.48/31.02)	DIEKVLTHTPRSVG...EGLPVIVAPSG
 1214- 1241 (43.77/21.03)	EVCKLGTHSPQHSGgqiEQSPGKYQPSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22640 with Med13 domain of Kingdom Viridiplantae
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