<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22622

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHEFSISLAMDTIIRQANVLRHGRWKEAISSERISDSTAGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSNLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKHEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITVGSDCAPRKRSLSDFLLDLPSLQGLKSGEPSKRRRISESAQSSLPLQTYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREILKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1742
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.197
Instability index50.80
Isoelectric point8.27
Molecular weight190231.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22622
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.88|      27|      29|     760|     786|       1
---------------------------------------------------------------------------
  761-  791 (46.25/27.32)	NHDLSSLS.......SPS..EHG....IADGNKPFQLAPsstlP
  792-  816 (27.06/12.56)	AHLVR..S.......SPA..IEGlgkaITVGS...DCAP.....
 1357- 1394 (26.57/12.18)	NHVAASLSragnamlSSSglASG....I..GGASVRLTPgtglP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     939|     960|       3
---------------------------------------------------------------------------
  939-  960 (42.14/29.52)	QDDSWKHICLRLGKAGSMSWDV
  963-  984 (42.82/30.14)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.03|      30|      31|     602|     632|       4
---------------------------------------------------------------------------
  352-  381 (29.70/13.29)	.KIEAGQDMQ...IKCQHSSfilDPL...TDKEANLS..
  603-  632 (53.58/31.53)	NKIDVGQMEK...IKHEKNS...NPF...DAKLHSLQSI
  634-  665 (32.75/12.62)	NCDDM..MDNqllIQ...NS..vDPLpllPACSPSFSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.78|      25|      28|     693|     720|       5
---------------------------------------------------------------------------
  682-  715 (31.96/23.62)	SPVRSlslgpqGVStrtISQMQDGALSHAQANNT
  716-  740 (44.82/25.38)	SIVRP......GVG...VNSYFPTSLSHLQSTNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     156.93|      48|     128|    1151|    1204|       7
---------------------------------------------------------------------------
 1151- 1204 (73.78/59.58)	GPllALGGAI.....RPARMPvTVSTGYSSMPKQTNNVPSQGPLANGSSATTMhhaSAP
 1283- 1335 (83.15/48.67)	GP..SVGGSLpcpqfRPFIME.HVAQGLNALEPAFMNATQPGPHLNTSAGAPQ...SAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     145.31|      42|     404|    1232|    1275|      10
---------------------------------------------------------------------------
 1232- 1275 (72.82/53.09)	LVP.......SSLLPFDVSVVLRgpYWIRIIYRKKFSVDMRCFAGDQVWLQ
 1632- 1680 (72.49/45.74)	LIPhmnvaggAAWLPYCVSVRLR..YSFGDNSHISFLAINGSHGGRACWLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.42|      12|      22|     828|     840|      11
---------------------------------------------------------------------------
  828-  840 (17.79/14.38)	LPsLQGLKSGEPS
  853-  864 (21.64/12.28)	LP.LQTYSSSSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      22|     884|     894|      12
---------------------------------------------------------------------------
  884-  894 (18.00/10.72)	ATVYASVLLHV
  909-  919 (20.22/12.98)	AQMYSSAIPYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.18|      28|     239|      25|      52|      13
---------------------------------------------------------------------------
   25-   52 (47.36/30.18)	LALRELVEKSQA..ESDWKGAYGGRQRSDS
  271-  300 (42.81/26.55)	LAMDTIIRQANVlrHGRWKEAISSERISDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      29|    1056|    1067|      15
---------------------------------------------------------------------------
 1056- 1067 (22.16/12.35)	VGMKSQSVNKGH
 1086- 1097 (25.19/15.10)	VGLMSFWFSYGH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22622 with Med14 domain of Kingdom Viridiplantae
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