<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22619

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHEFSISLAMDTIIRQANVLRHGRWKEAISSERISDSTAGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSNLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKHEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGVSTRTISQMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKPNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGKAITVGSDCAPRKRSLSDFLLDLPSLQGLKSGEPSKRRRISESAQSSLPLQTYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQNNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREILKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.199
Instability index50.84
Isoelectric point8.27
Molecular weight190061.38
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22619
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     100.68|      27|      28|     760|     786|       1
---------------------------------------------------------------------------
  761-  791 (46.25/28.17)	NHDLSSLS.......SPS..EHG..IADGNKPFQLAPsstlP
  792-  814 (27.86/13.56)	AHLVR..S.......SPA..IEGkaITVGS...DCAP.....
 1355- 1392 (26.57/12.53)	NHVAASLSragnamlSSSglASG..I..GGASVRLTPgtglP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     937|     958|       3
---------------------------------------------------------------------------
  937-  958 (42.14/27.91)	QDDSWKHICLRLGKAGSMSWDV
  961-  982 (42.82/28.50)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.03|      30|      31|     602|     632|       4
---------------------------------------------------------------------------
  352-  381 (29.70/17.35)	.KIEAGQDMQ...IKCQHSSfilDPL...TDKEANLS..
  603-  632 (53.58/40.79)	NKIDVGQMEK...IKHEKNS...NPF...DAKLHSLQSI
  634-  665 (32.75/16.49)	NCDDM..MDNqllIQ...NS..vDPLpllPACSPSFSSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     317.87|      89|     605|     666|     760|       5
---------------------------------------------------------------------------
  666-  760 (138.93/94.38)	VDetFECEHGSS..LPSASPVRSlslGPQGVSTRTISQMQDGALSHAqANNTSIVRPG...VGVNSYFPTSLSHLQSTNAFSSSNPVRN..SSAIKLSN.SKP
 1158- 1202 (33.66/11.57)	......................................................IRPArmpVTVSTGY.SSMP..KQTNNVPSQGPLAN.gSSATTMHHaSAP
 1260- 1349 (145.29/83.18)	VD..MRCFAGDQvwLQPATPPKG...GPSVGGSLPCPQFRPFIMEHV.AQGLNALEPA...F.MNATQPG..PHLNTSAGAPQSAPVANrlNATPGVAM.SRP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.46|      17|     404|    1230|    1248|       7
---------------------------------------------------------------------------
 1230- 1248 (26.95/23.84)	LVP.......SSLLPFDVSVVLRgpY
 1630- 1653 (28.52/16.78)	LIPhmnvaggAAWLPYCVSVRLR..Y
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      23|    1422|    1431|       8
---------------------------------------------------------------------------
 1422- 1431 (16.81/ 9.83)	LKKVLRGILK
 1446- 1455 (16.69/ 9.70)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.18|      28|     239|      25|      52|      10
---------------------------------------------------------------------------
   25-   52 (47.36/24.85)	LALRELVEKSQA..ESDWKGAYGGRQRSDS
  271-  300 (42.81/21.85)	LAMDTIIRQANVlrHGRWKEAISSERISDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      29|    1054|    1065|      12
---------------------------------------------------------------------------
 1054- 1065 (22.16/10.79)	VGMKSQSVNKGH
 1084- 1095 (25.19/13.20)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.91|      22|      23|     816|     838|      13
---------------------------------------------------------------------------
  816-  838 (33.25/22.71)	KRSLSDFLL.DLPsLQGLKSGEPS
  840-  862 (32.67/17.59)	RRRISESAQsSLP.LQTYSSSSQS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22619 with Med14 domain of Kingdom Viridiplantae
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