<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22615

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYTPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPTSTDKTSESENNEIKKELDSVNDPHLGADGQQKLESAEGLPALERTFIYPPEAVMVPMVHQAFVHFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSGHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVRENMQGTNSQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFSHHTMSPIQDVASKVQEPLKEIASPAVSQSFVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESIPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDLLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLNKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGTDSGASPLLEGSENDSAPSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDIIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSGTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAVQLTKEDSRHSVLSVSIVDYYGGTVQERMSRGVGSMSKQAVRHETSARDYETDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1803
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.291
Instability index60.12
Isoelectric point5.80
Molecular weight196273.57
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22615
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     374.79|     159|     497|     331|     605|       1
---------------------------------------------------------------------------
  331-  427 (88.90/112.49)	...........................................................................................................................................................................................GDL...................LADADSAACR.QSDL..PLNNDIAGSKVVSKRSRSEitevsshaG...KEVRENMQG..TNSQGGCS...WGWGEEGVVMDidillSEFGD.FSdfFQEDELDFGE
  515-  650 (128.32/96.65)	FLTRAEATLTFAPEYAAVEISSCETPATLFTnpyLpRSKkrGSCGFSSRVYSYDVTQSSKVESAGDKSE.KSDKLTPANLSRDV..........................................................................................................grsslytlvqgrkneseksLNNADEQSCKgETSR..PVSGETSFSSSLTLQKKSD......................................................................
  658-  735 (85.67/12.35)	FLLSMKTALATEIECITFQAAMCRIRHTLVS...L.RTK..ASAELKSALSSAMQTESSSNSDLVPKYDmKRKESIPARLSSDV.......................................................................................................................................................................................................................................
  839-  924 (71.90/ 6.88)	....................................................................................dhemydrsrlenvgvwrsvvvpkgakpldslsaktfsgtspsvqrqpivellsamallvqqstsfvdialdmddgdgsffwlsldeqrrrgfscdpsmvhagcGGL...................LGTCHSKDCA.GVDLvdPLSAEVSESSMI...............GllqSDIKSALKTafANMDGPLSvidWCRGRSNIAES.....AAMGDaYS..FHYTTGDIRE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     762.08|     255|     277|    1025|    1300|       2
---------------------------------------------------------------------------
  961- 1126 (177.70/118.60)	............................................................................................................................TIAVLPSPSLLVGYQDDWLKT.SANCLKLWeKAPLEPYASAKPVTYYAlcpDI...DL.LTSAATDFFmQLGTiyevcKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECP......DQLKSSgSHSVSISSVTEYFQALSKSWSVKSFLssLARIIKDIKLTLNISTNQKES.SNIPC
 1127- 1402 (393.09/262.87)	TVVYVVCPFPEPSAVLQTLVESSVALgSILSsererksflyaQVAKALNSSASADEASASNVVM..LSGF...SIPKLVLQIVTVETLLRLNKPNEL.AAFKDiAFTVYNKARRIPR....FVSTSDMFQSPTYMSRPQSTMMHT.ASPGPTLW.KECLAPRMSGQTLSRET...EF...DASMRSVSWDNSwQPGR.....AVGLPDPSKIPELCAQDDRKYAFEPLFILAEPgavdynDTMESS.RFGVDASSSRAYSSISGGTDSGASPL..LEGSENDSAPSLHCCYGWTEDwRWLVC
 1411- 1582 (191.29/108.82)	LLDSLIFPFGGISSRQDTTVLQSLFI.QILQ...........QGCQIMSSSPEASNTRSRDIIItrIGGFlelEIQEWQKAIYSFGGNEVKKWPVQLrRSIPD.GITSNSNGPTLEQqdmgLIQDRNMPSSPSTLYSPHSKSSFTkGQPGNK...KQILA.EQTGMDSSRGS...LHlvrSISLVAVSQDSS..............................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     175.44|      54|    1482|     108|     165|       3
---------------------------------------------------------------------------
  108-  165 (86.59/56.18)	LTHTPRSvGEGLPviVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNlPG..FTQPTICQL
 1592- 1647 (88.85/45.67)	LATRPTS.GEGNQ..SSGTGSSSYLDGFAPVKSIGSMSASYLLVPS.PSmrYLSPATLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22615 with Med13 domain of Kingdom Viridiplantae
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