<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22614

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMPDPLPPPVPAVAGGGDEDGPGAPPHPPPLPAHATEGELHATPAATRADEIGDASRQLNAASHVADFTLYCTGRNTGDFIKEVSLPSTLNMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYTPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPTSTDKTSESENNEIKKELDSVNDPHLGADGQQKLESAEGLPALERTFIYPPEAVMVPMVHQAFVHFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSGHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVSKRSRSEITEVSSHAGKEVRENMQGTNSQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFSHHTMSPIQDVASKVQEPLKEIASPAVSQSFVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESIPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDLLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLNKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGTDSGASPLLEGSENDSAPSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDIIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSGTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAVQLTKEDSRHSVLSVSIVDYYGGTVQERMSRGVGSMSKQAVRHETSARDYETDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1990
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.310
Instability index58.67
Isoelectric point5.61
Molecular weight216501.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22614
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     712.10|     195|     619|    1073|    1272|       1
---------------------------------------------------------------------------
 1073- 1272 (320.83/184.90)	NMDGP.LSVI.....DWcRGRSNI.AES.AAMGDAYSFHYttGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGyHRVRPTIAVLPSPSLLVGYQDDWLKT....SANCLKLWeKAPLEPYASAKPVTYYALCPDIDL.LTSAATDFFMQ.LGTIYEVCKLGT....HSPQHSGGQIEQSPGKYQSSGLVLVECP......DQLKSSGS.HSV.SISSVTEYF
 1428- 1549 (147.60/72.54)	...................................................................................TSDMFQSPTYMSRPQSTMMHT....ASPGPTLW.KECLAPRMSGQTLSRET...EFDAsMRSVSWDNSWQ.PGR.....AVGL....PDPSKIPELCAQDDRKYAFEPLFILAEPgavdynDTMESS.R.FGV.DASSSRAYS
 1568- 1762 (243.67/126.44)	NDSAPsLHCCygwteDW.RWLVCIwTDSrGELLDSLIFPF..GGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASN.TRSRDIIITRIGGFLELEIQ.EWQKAiysfGGNEVKKW............PVQLRRSIPDGIT.SNSNGPTLEQQdMGLIQDRNMPSSpstlYSPHSKSSFTKGQPGNKKQ...ILAEQT......GMDSSRGSlHLVrSISLV....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     181.39|      44|      98|     593|     637|       2
---------------------------------------------------------------------------
  593-  637 (71.66/50.80)	ILLSEFGDFSDF..FQEDELDFGEPPGTAESHALVTPASEYGDmPFI
  649-  683 (42.04/22.89)	QRLSPVG.FTSMeaFSHHTMS...PIQDVASK.VQEPLKE.......
  694-  736 (67.69/42.71)	VLSSSRSDFLT...RAEATLTFAPEYAAVEISSCETPATLFTN.PYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.28|      20|     494|    1300|    1376|       3
---------------------------------------------------------------------------
 1275- 1300 (24.32/51.95)	LSKSWSVKSFLssLARIIKdiklTLN
 1343- 1362 (33.97/14.01)	LSSERERKSFL..YAQVAK....ALN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.51|      19|      53|     228|     247|       4
---------------------------------------------------------------------------
  228-  247 (30.36/23.64)	RALRGLSYARFGDVFTkYTP
  282-  300 (33.15/20.88)	RYMRNLSSDDIEKVLT.HTP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.79|      22|      54|     427|     448|       6
---------------------------------------------------------------------------
  427-  448 (42.61/23.79)	VHQAFVHFSSKRMWSQDWMGSS
  478-  499 (37.18/19.82)	VNSNFLRLRRQRNSNSNGMASS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      24|      54|     950|     974|       7
---------------------------------------------------------------------------
  950-  974 (35.43/23.98)	LDSLSAKTFSgTSPSVQRQPIVELL
 1006- 1029 (45.56/26.67)	LDEQRRRGFS.CDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.72|      13|     494|     915|     931|       8
---------------------------------------------------------------------------
  897-  910 (20.03/12.12)	SSNSDLvPKYDMKR
  919-  931 (24.69/ 9.41)	SSDVDH.EMYDRSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.91|      26|      26|     753|     778|       9
---------------------------------------------------------------------------
  753-  778 (43.94/20.14)	SYDVTQSS.KVESAGDKSEKSDKLTPA
  781-  807 (36.96/15.91)	SRDVGRSSlYTLVQGRKNESEKSLNNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      72.69|      24|      26|     842|     866|      11
---------------------------------------------------------------------------
  842-  866 (35.98/29.33)	VGYFLLSMKTALATEIECiTFQAAM
  869-  892 (36.71/24.65)	IRHTLVSLRTKASAELKS.ALSSAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.10|      23|      50|     340|     368|      13
---------------------------------------------------------------------------
  187-  209 (42.71/20.43)	PEMTQPAVAKLRVVSSGLWVAPG
  343-  365 (44.39/28.69)	PGFTQPTICQLRGQSYYVEVALG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22614 with Med13 domain of Kingdom Viridiplantae
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