<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22613

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYTPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPTSTDKTSESENNEIKKELDSVNDPHLGADGQQKLESAEGLPALERTFIYPPEAVMVPMVHQAFVHFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSGHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVSKRSRSEITEVSSHAGKEVRENMQGTNSQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFSHHTMSPIQDVASKVQEPLKEIASPAVSQSFVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESIPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDREGASHDSSRDNAGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDLLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLNKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGTDSGASPLLEGSENDSAPSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDIIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSGTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAVQLTKEDSRHSVLSVSIVDYYGGTVQERMSRGVGSMSKQAVRHETSARDYETDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1814
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index60.14
Isoelectric point5.76
Molecular weight197401.59
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22613
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     248.96|      78|     616|     101|     324|       1
---------------------------------------------------------------------------
    9-   93 (117.27/117.94)	LRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGdvftkyTPPTRNQNSfRRAQPTVEFVFAATEEAIFVHVIISA
  165-  242 (131.69/139.02)	LRGQSYYVEVALGFPPTSTDKTSESENNEIKKELDSVNDPHLG......ADGQQKLES.AEGLPALERTFIYPPEAVMVPMVHQA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     355.62|     108|     616|     973|    1096|       2
---------------------------------------------------------------------------
  978- 1095 (169.29/140.89)	SPSLLVGYQDDWLKTSANCLKLWeKAPLEPYASAKPVTYYAlcpDIDL.LTSAATDFFMQLGTiyevcKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECP......DQLKSSgSHSVSISSVTEY
 1258- 1372 (186.33/109.72)	SPTYMSRPQSTMMHTASPGPTLW.KECLAPRMSGQTLSRET...EFDAsMRSVSWDNSWQPGR.....AVGLPDPSKIPELCAQDDRKYAFEPLFILAEPgavdynDTMESS.RFGVDASSSRAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.95|      43|      98|     405|     449|       3
---------------------------------------------------------------------------
  405-  449 (67.43/52.33)	ILLSEFGDFSDfFQEDELDFGEPPGTAESHALVTPASEYGDmPFI
  506-  548 (72.52/46.08)	VLSSSRSDFLT.RAEATLTFAPEYAAVEISSCETPATLFTN.PYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      22|     384|    1374|    1400|       4
---------------------------------------------------------------------------
 1374- 1400 (30.81/27.87)	SISGGTdsgASPLLegSENDSAPSLHC
 1766- 1787 (44.55/23.65)	SLSWMT...VSPVY..MERRSALPFHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.84|      33|     321|     595|     634|       5
---------------------------------------------------------------------------
  558-  593 (48.03/24.56)	GFSSrvySYDVTQSSKVESAGDKSEKSDKLTPANLS
  597-  629 (54.81/33.19)	GRSS...LYTLVQGRKNESEKSLNNADEQSCKGETS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     193.38|      60|     492|     331|     399|       6
---------------------------------------------------------------------------
  331-  399 (95.84/73.00)	GDLLADADSAACRQSDL..PLNNDIAGSKVSKRSRSEITEvsshAGKEVRENMqgtnsQGGCS...WGWGEEGV
  838-  902 (97.54/55.80)	GGLLGTCHSKDCAGVDLvdPLSAEVSESSMIGLLQSDIKS....ALKTAFANM.....DGPLSvidWCRGRSNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.90|      40|     384|    1146|    1188|       7
---------------------------------------------------------------------------
 1099- 1163 (46.11/36.03)	LSKSWSVKSFLssLARIIKdiklTLNIStnqkessnipctvvyvvcpFPEPSAVLQTL.VESSVAL
 1167- 1223 (51.79/31.68)	LSSERERKSFL..YAQVAK....ALNSS...asadeasasnvvmlsgFSIPKLVLQIVtVETLLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.27|      16|     492|     727|     743|       8
---------------------------------------------------------------------------
  694-  709 (24.54/ 6.75)	AELKSALSSAMQTESS
  728-  743 (27.73/13.36)	ARLSSDVDHEMYDRSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.96|      38|    1493|     108|     164|      10
---------------------------------------------------------------------------
  115-  154 (61.60/66.28)	VGEGLPVIVaPSGM..LGRL.....VGCCPSdLARQVYSSKLSAPNL
  747-  791 (56.36/20.19)	VGVWRSVVV.PKGAkpLDSLsaktfSGTSPS.VQRQPIVELLSAMAL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22613 with Med13 domain of Kingdom Viridiplantae
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