<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22612

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYTPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPTSTDKTSESENNEIKKELDSVNDPHLGADGQQKLESAEGLPALERTFIYPPEAVMVPMVHQAFVHFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSGHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVRENMQGTNSQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFSHHTMSPIQDVASKVQEPLKEIASPAVSQSFVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESIPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDREGASHDSSRDNAGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDLLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLNKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGTDSGASPLLEGSENDSAPSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDIIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSGTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAVQLTKEDSRHSVLSVSIVDYYGGTVQERMSRGVGSMSKQAVRHETSARDYETDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1914
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.08
Grand average of hydropathy-0.312
Instability index58.93
Isoelectric point5.70
Molecular weight208791.12
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22612
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.41|      22|      22|     238|     259|       1
---------------------------------------------------------------------------
  238-  259 (38.08/23.52)	LARQVYSSKLSAPNLPGFTQPT
  263-  284 (38.33/23.73)	LRGQSYYVEVALGFPPTSTDKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     355.62|     108|     615|    1073|    1196|       2
---------------------------------------------------------------------------
 1078- 1195 (169.29/138.85)	SPSLLVGYQDDWLKTSANCLKLWeKAPLEPYASAKPVTYYAlcpDIDL.LTSAATDFFMQLGTiyevcKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECP......DQLKSSgSHSVSISSVTEY
 1358- 1472 (186.33/108.12)	SPTYMSRPQSTMMHTASPGPTLW.KECLAPRMSGQTLSRET...EFDAsMRSVSWDNSWQPGR.....AVGLPDPSKIPELCAQDDRKYAFEPLFILAEPgavdynDTMESS.RFGVDASSSRAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.97|      16|     322|     209|     224|       3
---------------------------------------------------------------------------
  209-  224 (29.26/13.99)	TPRSVGEGLPVIVAPS
  538-  553 (31.72/15.75)	TPASEYGDMPFIDSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.37|      22|     389|    1474|    1500|       5
---------------------------------------------------------------------------
 1474- 1500 (30.81/26.41)	SISGGTdsgASPLLegSENDSAPSLHC
 1866- 1887 (44.55/22.41)	SLSWMT...VSPVY..MERRSALPFHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     181.81|      60|     389|     584|     662|       6
---------------------------------------------------------------------------
   98-  164 (90.93/55.85)	EMTQPAVAKLRVVSSglwvapGNSEEVAAAlCQALRNSLERALRGLSYARF.GDVFTK.YTPPTRNQNS
  595-  656 (90.88/79.88)	EIASPAVSQSFVLSS......SRSDFLTRA.EATLTFAPEYAAVEISSCETpATLFTNpYLPRSKKRGS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.72|      29|     389|     396|     463|       7
---------------------------------------------------------------------------
  430-  458 (49.61/70.13)	GDLLADADSAACRQSDL..PLNNDIAGSKVV
  938-  968 (47.11/ 7.18)	GGLLGTCHSKDCAGVDLvdPLSAEVSESSMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.84|      33|     324|     695|     734|       8
---------------------------------------------------------------------------
  658-  693 (48.03/27.44)	GFSSrvySYDVTQSSKVESAGDKSEKSDKLTPANLS
  697-  729 (54.81/37.06)	GRSS...LYTLVQGRKNESEKSLNNADEQSCKGETS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.09|      24|     795|    1031|    1054|      12
---------------------------------------------------------------------------
 1031- 1054 (44.37/29.24)	GG...DAMSPPQSSSDREGASHDSS.RD
 1821- 1848 (33.71/19.93)	GGtvqERMSRGVGSMSKQAVRHETSaRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.65|      22|      24|     756|     778|      14
---------------------------------------------------------------------------
  756-  778 (32.93/24.27)	YFLLSMKTALATEIECiTFQAAM
  783-  804 (33.72/20.02)	HTLVSLRTKASAELKS.ALSSAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.15|      13|      28|     367|     379|      15
---------------------------------------------------------------------------
  367-  379 (24.61/13.34)	NFSPSSYFRNSSS
  392-  404 (23.54/12.42)	NFLRLRRQRNSNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.08|      11|    1009|     730|     740|      17
---------------------------------------------------------------------------
  730-  740 (21.20/12.15)	RPVSGETSFSS
 1706- 1716 (21.88/12.81)	RPTSGEGNQSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22612 with Med13 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQT
2) NSIPIGGDAMSPPQSSSDREGASHDSSRDNAGTSEEHHK
3) STDKTSESENNEIKKELDSVNDPHLGADGQQKLE
1613
1026
280
1668
1064
313










Molecular Recognition Features






MoRF SequenceStartStop




1) FFQEDELDF
516
524