<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22611

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMASSISSVSSTSNGSGHAVAAKGGDLLADADSAACRQSDLPLNNDIAGSKVSKRSRSEITEVSSHAGKEVRENMQGTNSQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVTPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFSHHTMSPIQDVASKVQEPLKEIASPAVSQSFVLSSSRSDFLTRAEATLTFAPEYAAVEISSCETPATLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESIPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPLGTIYEVCKLGTHSPQHSGGQIEQSPGKYQSSGLVLVECPDQLKSSGSHSVSISSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYAQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLNKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRAYSSISGGTDSGASPLLEGSENDSAPSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDIIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGITSNSNGPTLEQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQPGNKKQILAEQTGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLLATRPTSGEGNQSSGTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAVQLTKEDSRHSVLSVSIVDYYGGTVQERMSRGVGSMSKQAVRHETSARDYETDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQPTDKGDVS
Length1472
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.303
Instability index62.18
Isoelectric point5.63
Molecular weight159574.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22611
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     886.35|     339|     386|     294|     677|       1
---------------------------------------------------------------------------
   24-  127 (53.63/14.40)	................................................................................................................................GD..LLADADSAACRQSDL..PLNNDIAGSKVSKRSRSEITEvsshAGKEVR.ENMQGtnSQGGCSWGWG............EEGVVMD.IDILL.......SEFGDFSDFFQEDEL..DFGEPP......GTAESH...............................................................................................................................................................................................................................................................................................................................................
  294-  420 (20.92/67.01)	......................................................................................................................................................................................................................................................................................................alvtpaseygdmpfidspsiamdipeqrlspvgftsmeafshhtmspiqdvaskvqeplkeiaspavsqsfvlsssrsdfltraeatltfapeyaaveisscetpatlftnpylprskkrgscgfssrvysydvtqsskvesagdkseksdkltpanlsrdvgrssL..YTlvqgrkneSEKSLNNADEqSCKGETSRPV.SG...ETS....FSSSLTLQKKSDNMLNVGYFLLSMKTalATEiecitFQaAMCR...IRHTLVSLrTKASAELKSALSSAMQTESSSNsdlvpkydmkrkesIP
  421-  794 (532.07/376.74)	ARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSlSAktfSGTSPSVQRQPIVELLSAMALLVQQST..............SFVDIALDMDDGDGSF..FWLSLDEQRRRGFSCDP..SMVHAGCGG..LLGTCHSKDCAGVDLvDPLSAEVSESSMIGLLQSDIKS....ALKTAF.ANMDG..PLSVIDWCRGR.......SNIAESAAMGD.AYSFH.......YTTGDIRETSNSIPIGGDAMSPPQSSSDRGTSEEHhKGYHRVRPTIAVLPSPSL..LVGYQDDW.......................................................................................................................................................lktsanclklwekapLepYA........SAKPLGTIYE.VCKLGTHSPQhSGgqiEQSpgkyQSSGLVLVECPDQLKSSGSHSVSISS..VTE....yFQ.ALSKswsVKSFLSSL.ARIIKDIKLTLNISTNQKESSN..............IP
  809- 1066 (279.73/167.05)	AVLQTLVESSVALGSILSSERERKSFLYAQVAKALNS.SA...SADEASASNVVMLSGFSIPKLVLQIVTvetllrlnkpnelaAFKDIAFTVYNKARRIprFVSTSDMFQSPTYMSRPqsTMMHTASPGptLWKECLAPRMSG....QTLSRE.......................TEFdASMRS..VSWDNSWQPGRavglpdpSKIPELCAQDDrKYAFEplfilaePGAVDYNDTMESSRFGVDASSSRAYSSISGGTD...SGASPLLEGSENDSAPSLhcCYGWTEDW..................................................................................................................................................................................................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.48|      11|      15|    1272|    1282|       2
---------------------------------------------------------------------------
 1272- 1282 (20.39/ 9.02)	QSSGTGSSSYL
 1289- 1299 (20.09/ 8.77)	KSIGSMSASYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.95|      25|     287|    1075|    1099|       3
---------------------------------------------------------------------------
 1075- 1099 (43.99/25.58)	DSRGELLD.SLIFPFGG.ISSRQDTTV
 1364- 1390 (35.96/19.59)	DSRHSVLSvSIVDYYGGtVQERMSRGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.93|      12|      15|    1234|    1245|       4
---------------------------------------------------------------------------
 1234- 1245 (19.65/12.21)	SLHLVRSISLVA
 1251- 1262 (21.28/13.86)	SLHLACQADLLA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.44|      50|    1157|     141|     190|       5
---------------------------------------------------------------------------
  141-  190 (88.37/60.38)	FIDSPSIAMDIPEQRLSPVGFTS.MEAFSH..H...TMSPIQ..DVASKVQEPLKEIA
 1300- 1357 (70.06/46.03)	LVPSPSMRYLSPATLQLPTCLTSeSPPLAHllHskgTATPLAmgYVVSKAVPPVRKNA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.68|      11|      17|    1171|    1181|       6
---------------------------------------------------------------------------
 1171- 1181 (20.36/11.38)	GITSNSNGP....TL
 1187- 1201 (15.32/ 6.72)	GLIQDRNMPsspsTL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22611 with Med13 domain of Kingdom Viridiplantae
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