<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22604

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMMQSHMPSPARLGVTASSPSLPPNQSPANPTSSPPQQANPPPASAAASAAGAAVPTLTTSPALLPLLPPLPRAQSLLHLISSLASNLFELAPNRAAWISSYRGSLPNFLASSSASAAPTPLPAPVSTTKEAMSMLTSLQTQLFETVAELQETLDLQDARAKLAREARAKDASLLAFAKKLREAHHVLDRLVDDYADYRRDPKRPRGAAAVDEPEPVSHGDFGASLHSKLKLDDILTYAHRISYTTFAPPEHGAGLPLRGALPPAPQDNELRMSQLYQFADLDVGVPKKPLETEGVTAEMESMPLFELPVEEPPRPSMLPITVPPGWQKGLPALLPDIPVPPPGWKPGDPIELGGIIPAVKPEEQRPSVPIPVGVQPMVPRAQEPIQVAAVNLDIISSSSDEYSSDVGSSDEDDED
Length415
PositionMiddle
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.04
Grand average of hydropathy-0.279
Instability index62.71
Isoelectric point4.91
Molecular weight44116.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU364141

GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.43|      15|      16|     315|     329|       1
---------------------------------------------------------------------------
  315-  329 (35.00/18.10)	PSMLP.ITV.PPGWQKG
  331-  347 (25.43/11.09)	PALLPdIPVpPPGWKPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     159.94|      47|      51|       8|      55|       2
---------------------------------------------------------------------------
    8-   36 (44.54/11.51)	.......................SPARLG..VTASSPSLPPNQSPANPTSSPPQ
   37-   85 (64.05/22.16)	QANPPPASAAASAAGaAVPtlttSPALLP..LL...PPLPRAQSLLHLISSLAS
   89-  126 (51.35/14.49)	ELAPNRAAWISSYRG.SLP..........nfLASSSASAAPTPLPA.PVS....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.56|      34|      52|     171|     207|       3
---------------------------------------------------------------------------
  171-  207 (54.63/46.18)	ASL...LAFAKKLREAHHVldrLVDDYADYRRDPKRP.RGA
  223-  260 (50.93/34.26)	ASLhskLKLDDILTYAHRI...SYTTFAPPEHGAGLPlRGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.64|      14|      17|     349|     364|       4
---------------------------------------------------------------------------
  349-  364 (17.49/16.82)	PIELgGIIPAVkPEEQ
  369-  382 (28.15/15.30)	PIPV.GVQPMV.PRAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.41|      21|      25|     262|     286|       5
---------------------------------------------------------------------------
  265-  286 (33.96/24.56)	PQDNE...LRMSQLYQFaDLDVGVP
  289-  312 (32.45/11.52)	PLETEgvtAEMESMPLF.ELPVEEP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22604 with Med4 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MMQSHMPSPARLGVTASSPSLPPNQSPANPTSSPPQQANPPPASAAASAAGA
2) PALLPDIPVPPPGWKPGDPIELGGIIPAVKPEEQRPSVPIPVGVQPMVPRAQE
1
331
52
383










Molecular Recognition Features






MoRF SequenceStartStop




NANANA