<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22597

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRELVEKSQVESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEASSISVTDGIAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHELSISLAMDTIIRQANVLRHGRWKEAISSERIPDSTTGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQICQSPKDVILKRDIGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIGLGVNIRSGRFILQSPKNILPPSALLDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKFNANIDAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLSLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGGSTRTISHMQDGALSHAQANNTSIVRPGVGVNSYFPTSLSHLQSTNAFSSSNPVRNSSAIKLSNSKSNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITVGADCAPRKRSLSDFLLDLPSLQGLKSSEPSKRRKISESVQSSLPLQAYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDADGVVLTYSSVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEQMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVTSQGPVANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSVPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWLQSEDWERCKQKVARAAETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1742
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.190
Instability index50.22
Isoelectric point8.25
Molecular weight190166.53
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22597
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.06|      14|      28|     707|     720|       1
---------------------------------------------------------------------------
  707-  720 (25.31/14.30)	LSHAQANNT.SIVRP
  732-  746 (20.75/10.40)	LSHLQSTNAfSSSNP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.73|      25|      28|     768|     794|       2
---------------------------------------------------------------------------
  768-  794 (42.50/31.20)	SSPSEHGIadGNKPFQLAPSSTLPAHL
 1373- 1397 (43.23/24.90)	SSGLASGI..GGASVRLTPGTGLPVHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.31|      21|      22|     816|     837|       4
---------------------------------------------------------------------------
  816-  837 (32.45/28.06)	P.RKRSLSDFLL.DLPsLQGLKSS
  839-  861 (27.85/17.75)	PsKRRKISESVQsSLP.LQAYSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     129.83|      31|     607|     662|     694|       5
---------------------------------------------------------------------------
  662-  694 (52.97/41.10)	FSsiVDETFECEH.GSS..LPSASP..VRSLSLGPQGG
 1260- 1287 (43.97/26.96)	FS..VD..MRCFA.GDQvwLQPATP..PKG...GPSVG
 1295- 1323 (32.89/17.77)	F.....RPFIMEHvAQG..LNALEPafMNATQPGPH..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.95|      28|     607|     302|     354|       6
---------------------------------------------------------------------------
  307-  334 (53.19/27.01)	NAAVMQLGQDGEFDSSGFRLPVLK......LNY....W
 1402- 1439 (43.76/12.57)	NTAFIGLGDDGGYGGGWVPLAALKkvlrgiLKYlgvlW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     939|     960|       7
---------------------------------------------------------------------------
  939-  960 (42.14/28.94)	QDDSWKHICLRLGKAGSMSWDV
  963-  984 (42.82/29.55)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      28|    1056|    1067|       8
---------------------------------------------------------------------------
 1056- 1067 (22.16/13.90)	VGMKSQSVNKGH
 1086- 1097 (25.19/16.94)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.93|      13|      22|    1336|    1348|       9
---------------------------------------------------------------------------
 1336- 1348 (23.85/13.09)	VANRLNAT...PGVAM
 1355- 1370 (18.08/ 8.18)	VANHVAASlsrAGNAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.07|      17|      22|     347|     363|      10
---------------------------------------------------------------------------
  347-  363 (30.44/19.13)	LSPFIKIEAGQDMQIKC
  370-  386 (28.62/17.54)	LDPLTDKEANLSLDLSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      22|     884|     894|      11
---------------------------------------------------------------------------
  884-  894 (18.00/11.89)	ATVYASVLLHV
  909-  919 (20.22/14.37)	AQMYSSAIPYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.88|      21|     914|     232|     252|      13
---------------------------------------------------------------------------
  232-  252 (36.56/21.78)	IKLGEIRRFALGDDIER.RMAV
 1146- 1167 (33.33/19.20)	IRLTAGPLLALGGAIRPaRMPV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.42|      19|      27|     500|     518|      14
---------------------------------------------------------------------------
  500-  518 (32.22/22.33)	GSNTATEVF....SSLR.TRSILH
  524-  547 (24.20/14.65)	GSFFGLKVYeqsqGTLKiPEAILH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22597 with Med14 domain of Kingdom Viridiplantae
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