<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22571

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRDLVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSSISVTDGVAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHELSISLAMDTIIRQANVLRHGRWKEAISSERISDSTTGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVVLKRDVGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIVLGVNIRSGRFILQSPKNILPPSALVDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKLNANIGAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGASTRTISQMQDGALSHAQANNTSIVCPGVGVNSYFQNSLSHLQSTNAFLSSNPVRNSSAIKLSNSKSNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGKAITLGADCAPRKRSLSDFLLDLPSLQGLKSSEPSKRRKISESAQSSLPLQAYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDVDGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEHMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWQQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1740
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.189
Instability index49.82
Isoelectric point8.25
Molecular weight189944.29
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22571
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.63|      28|      35|    1281|    1313|       2
---------------------------------------------------------------------------
 1281- 1313 (48.72/38.83)	GPSVGGSLPCPQFRPfimehVAQGLNALEPAFM
 1319- 1346 (51.91/29.40)	GPHLNTSAGAPQSAP.....VANRLNATPGVAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.33|      31|      34|     369|     402|       3
---------------------------------------------------------------------------
  369-  402 (47.07/34.59)	ILDPLTDKEANLSLDLSCIDVeklILK...AIACNRH
  405-  438 (44.26/25.45)	LLDIQRQLCKNVQISQSPKDV...VLKrdvGVAKAPH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      22|    1422|    1431|       5
---------------------------------------------------------------------------
 1422- 1431 (16.81/11.37)	LKKVLRGILK
 1446- 1455 (16.69/11.22)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.13|      21|      22|     817|     838|       6
---------------------------------------------------------------------------
  817-  838 (31.99/19.39)	RSLSDFLL.DLPsLQGLKSSEPS
  841-  862 (31.14/14.60)	RKISESAQsSLP.LQAYSSSSQS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.73|      11|      28|     768|     778|       7
---------------------------------------------------------------------------
  768-  778 (21.39/11.56)	SSPSEHG..IADG
  797-  809 (15.35/ 6.19)	SSPAIEGkaITLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.23|      12|     605|     783|     794|       8
---------------------------------------------------------------------------
  783-  794 (21.66/12.08)	QLAPSSTLPAHL
 1384- 1395 (23.57/13.89)	RLTPGTGLPVHM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     155.77|      40|     605|     302|     354|       9
---------------------------------------------------------------------------
  189-  231 (40.38/16.65)	..TDGVAVF....RV..DGEFKvllTLGYR........GNLDLWrilhmelLVGEKNGP
  303-  342 (77.02/69.64)	GQTGNAAVM....QLGQDGEFD...SSGFRLP.....VLKLNYW.......LDGKNSGP
 1211- 1250 (38.38/18.34)	GHTLHTAAMlsaaGRGGPGLVP...SS..LLPfdvsvVLRGPYW.......I.......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.96|      22|      22|     937|     958|      10
---------------------------------------------------------------------------
  937-  958 (42.14/30.07)	QDDSWKHICLRLGKAGSMSWDV
  961-  982 (42.82/30.70)	NDPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.79|      41|     912|     577|     624|      11
---------------------------------------------------------------------------
  577-  624 (57.29/55.22)	FHLLETQSDASNKLNANIGAKEamrVNKIdvgqMEKIKYEKNSNPFDA
 1499- 1539 (71.50/47.67)	FHHQQQQQQAQSNAQEELTSAE...INEI....CDYFSRRVASEPYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.35|      12|      29|    1054|    1065|      12
---------------------------------------------------------------------------
 1054- 1065 (22.16/12.33)	VGMKSQSVNKGH
 1084- 1095 (25.19/15.06)	VGLMSFWFSYGH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.67|      20|      22|    1162|    1183|      14
---------------------------------------------------------------------------
 1162- 1183 (31.57/25.02)	RMPvtVSTGYSSMPKQTNNVPS
 1184- 1203 (35.10/21.27)	QGP..LANGSSATTMHHASAPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      22|     882|     892|      15
---------------------------------------------------------------------------
  882-  892 (18.00/11.52)	ATVYASVLLHV
  907-  917 (20.22/13.96)	AQMYSSAIPYV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.51|      28|     255|      25|      52|      16
---------------------------------------------------------------------------
   25-   52 (47.66/24.35)	LALRDLVEKSQA..ESDWKGAYGGRQRSDS
  271-  300 (42.86/21.26)	LAMDTIIRQANVlrHGRWKEAISSERISDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.34|      21|     624|     744|     765|      21
---------------------------------------------------------------------------
  744-  765 (32.75/24.26)	SNP...VRNSSAIKLSNSkSNHDLS
 1347- 1370 (31.59/18.35)	SRPtssVANHVAASLSRA.GNAMLS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22571 with Med14 domain of Kingdom Viridiplantae
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