<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22569

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGSVVRRAAEESYLALRDLVEKSQAESDWKGAYGGRQRSDSEKKIDLLKFIARTRQRMLRLHVLAKWCQQVPLVQYCQQLGSTLSSHETCFTQTADSLFFMHEGLQQARAPTFDVPSALEVMLTGSYQRLPRCIEDIGSQNKLSPDEEKHALQKLDTSVRYKVLVTPRPKEVSSISVTDGVAVFRVDGEFKVLLTLGYRGNLDLWRILHMELLVGEKNGPIKLGEIRRFALGDDIERRMAVSENPFSVLYAILHELSISLAMDTIIRQANVLRHGRWKEAISSERISDSTTGQTGNAAVMQLGQDGEFDSSGFRLPVLKLNYWLDGKNSGPAESDLSPFIKIEAGQDMQIKCQHSSFILDPLTDKEANLSLDLSCIDVEKLILKAIACNRHTRLLDIQRQLCKNVQISQSPKDVVLKRDVGVAKAPHKKTEKASFADFCGNEVLQVRAYGQAYIVLGVNIRSGRFILQSPKNILPPSALVDWEEALNKGSNTATEVFSSLRTRSILHLLVSTGSFFGLKVYEQSQGTLKIPEAILHGSDLMVMGFPQCANAYYLLMQLDKDFRPVFHLLETQSDASNKLNANIGAKEAMRVNKIDVGQMEKIKYEKNSNPFDAKLHSLQSIENCDDMMDNQLLIQNSVDPLPLLPACSPSFSSIVDETFECEHGSSLPSASPVRSLSLGPQGASTRTISQMQDGALSHAQANNTSIVCPGVGVNSYFQNSLSHLQSTNAFLSSNPVRNSSAIKLSNSKSNHDLSSLSSPSEHGIADGNKPFQLAPSSTLPAHLVRSSPAIEGLGKAITLGADCAPRKRSLSDFLLDLPSLQGLKSSEPSKRRKISESAQSSLPLQAYSSSSQSGTSLTHGNNILAERNNCVPATVYASVLLHVIRHCSLCIKHAQLTAQMYSSAIPYVEEVGMRSPSSNIWFRLPFAQDDSWKHICLRLGKAGSMSWDVRINDPHFKELWELNGGSTSTPWGVGVRIANTSEMDSHISFDVDGVVLTYSTVEADSVKRLVSDLQRLANARVFARGMRRLIGVKLDDKLDDNHISVGMKSQSVNKGHSDADRLSEHMGKPFRIEAVGLMSFWFSYGHMPMVHFVVEWETAKEGCTMHVSPDQLWPHTKFLEDFVNGGEVASFLDCIRLTAGPLLALGGAIRPARMPVTVSTGYSSMPKQTNNVPSQGPLANGSSATTMHHASAPSNATAHLGGHTLHTAAMLSAAGRGGPGLVPSSLLPFDVSVVLRGPYWIRIIYRKKFSVDMRCFAGDQVWLQPATPPKGGPSVGGSLPCPQFRPFIMEHVAQGLNALEPAFMNATQPGPHLNTSAGAPQSAPVANRLNATPGVAMSRPTSSVANHVAASLSRAGNAMLSSSGLASGIGGASVRLTPGTGLPVHMKGELNTAFIGLGDDGGYGGGWVPLAALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFYVGGYVFAVSVHRVQLLLQVLSVKRFHHQQQQQQAQSNAQEELTSAEINEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLITWKKGFSQAHGDIATAQRARIELCLENHSGSASDDRTESSLAKSNIHHDRAHSSVEFALTFVLDHALIPHMNVAGGAAWLPYCVSVRLRYSFGDNSHISFLAINGSHGGRACWQQSEDWERCKQKVARAVETVNGTPAVAEPGQGRLRMVAEMIQKQLQLCLQQLRDGPLSAGSTAS
Length1742
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.187
Instability index49.78
Isoelectric point8.25
Molecular weight190114.50
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22569
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.63|      28|      35|    1283|    1315|       1
---------------------------------------------------------------------------
 1283- 1315 (48.72/35.75)	GPSVGGSLPCPQFRPfimehVAQGLNALEPAFM
 1321- 1348 (51.91/27.08)	GPHLNTSAGAPQSAP.....VANRLNATPGVAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     104.37|      32|      35|     361|     395|       3
---------------------------------------------------------------------------
  361-  395 (49.14/51.90)	IKCQHSSFILDPLTDKEANLSLDLSCIDVeklILK
  397-  428 (55.22/47.89)	IACNRHTRLLDIQRQLCKNVQISQSPKDV...VLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.24|      21|      22|     816|     837|       5
---------------------------------------------------------------------------
  816-  837 (32.42/23.20)	P.RKRSLSDFLL.DLPsLQGLKSS
  839-  861 (27.82/14.58)	PsKRRKISESAQsSLP.LQAYSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.50|      10|      22|    1424|    1433|       6
---------------------------------------------------------------------------
 1424- 1433 (16.81/14.30)	LKKVLRGILK
 1448- 1457 (16.69/14.12)	LKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     213.65|      59|     607|     744|     805|       7
---------------------------------------------------------------------------
  744-  805 (96.51/49.07)	SNP...VRNSSAIKLSNSkSNHDLSslSSPSEHGIADGNKPFQLAPSSTLPAHL.VRSSPAIEGLG
 1217- 1239 (26.10/ 6.76)	.........HTAAMLS...................AAGRGGPGLVPSSLLP...............
 1349- 1409 (91.03/39.33)	SRPtssVANHVAASLSRA.GNAMLS..SSGLASGI..GGASVRLTPGTGLPVHMkGELNTAFIGLG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.72|      21|      21|     940|     960|       8
---------------------------------------------------------------------------
  940-  960 (40.53/20.89)	DDSWKHICLRLGKAGSMSWDV
  964-  984 (41.19/21.34)	DPHFKELWELNGGSTSTPWGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.98|      38|     115|     184|     231|       9
---------------------------------------------------------------------------
  184-  231 (57.62/64.20)	SSISVTDGVAVFRV..DGEFKvllTLGYR...GNLDLWrilhmelLVGEKNGP
  300-  342 (61.36/42.72)	STTGQTGNAAVMQLgqDGEFD...SSGFRlpvLKLNYW.......LDGKNSGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.79|      41|     914|     577|     624|      10
---------------------------------------------------------------------------
  577-  624 (57.29/66.90)	FHLLETQSDASNKLNANIGAKEamrVNKIdvgqMEKIKYEKNSNPFDA
 1501- 1541 (71.50/57.73)	FHHQQQQQQAQSNAQEELTSAE...INEI....CDYFSRRVASEPYDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.23|      11|      23|     884|     894|      13
---------------------------------------------------------------------------
  884-  894 (18.00/13.02)	ATVYASVLLHV
  909-  919 (20.22/15.75)	AQMYSSAIPYV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22569 with Med14 domain of Kingdom Viridiplantae
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