<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22542

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMGDDLRLDLDKLPIKRLEAIDEAGNEHYPPDTSSEEQRLAAIRRVDFSWVVERDAKKAKKAAAEDAAQKAWPWQGLHESLQLAQQELTVVLDLISTVEVNDTVAVATISKPRPLPDEILVDMAVSAATKLQRLRHLGRYFKQSAKTMQQQFQKEARFYGSLIRLQQNWKVKRQRGNAPGINSFMFDVVDTSQLDTVAMPRMSSLSLVQIDQDSSGTLSVQVPQKACRFLSLQFRRDSANGPESYACRTKGVSSTTSSAAEDDVLEDDDVNKSVKQAHSILRNIHKSIFEEQVLDMVIRETFVQTQGVNVTGMREDFLQLAIGEESLLCLSLVDSGQDSDSEMAGHEGHNNSEANLVLATTNGKQEPLKRDTSGFLNPKSLEIYLLHLFHENILRKVREKYRNIVRYQSPAQTAESAGEDCRLLSHFCMTVAHKTYSKKVQLELESVVSRVPYLQLRSLPTWHSRTSSWSLCLRVPQPILAADRPTKPSDNGEPKYKSSRTQFNTKIVLKDGQISLLGEGSPSIAGSLTRKPSDGYLINSYNCDLEDLPTMVLQQVASQIINWLHEEALVLGMSVTRDFLCLYFDLEHGDTLGLVAHVDPDDEYGCISWYLTVDHPVEDDGKAPAADDAWAEKRRFLGYLSLEVLYSTLLDLINLCGTGSRPLR
Length663
PositionHead
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.392
Instability index47.31
Isoelectric point5.56
Molecular weight74324.22
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22542
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.57|      32|     124|     179|     213|       1
---------------------------------------------------------------------------
  179-  213 (47.90/43.06)	GIN.SFMFDvvDTSQLdTVAMPRMSSLSLVQIDQDS
  306-  338 (51.67/34.60)	GVNvTGMRE..DFLQL.AIGEESLLCLSLVDSGQDS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.61|      34|     250|     214|     249|       2
---------------------------------------------------------------------------
  214-  249 (54.92/37.25)	SGTLSVQVPQKAcrFLSLQFRRDSANGPESY.ACRTK
  467-  501 (58.69/33.14)	SWSLCLRVPQPI..LAADRPTKPSDNGEPKYkSSRTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.71|      43|     556|      48|      94|       3
---------------------------------------------------------------------------
   48-   94 (66.02/59.74)	SWVVERD...AKKAKKAAAEDAAQKAWPWQGlHESLQLAQQELtvvLDLI
  607-  652 (70.69/50.49)	SWYLTVDhpvEDDGKAPAADDAWAEKRRFLG.YLSLEVLYSTL...LDLI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22542 with Med17 domain of Kingdom Viridiplantae
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