<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22538

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMLHPPSPPVPAVAGGGEEDGPGAPAHPPPLPACTTKGELHATPAATRADEIGGASRQLNAAGHVADFTLYCTGRNTGDFIKAVSLPSTLNMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHIPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKTSESENNQIRKELDSVNDPHLGADGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSPWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSEHAIAAKGGDLLADADSAACRQSDLPLNNDIAGSKVSKRSRSEITEVSSHAGKEVNMQGTNGQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVPPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFNHHTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCEMPTTLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTAANLSRDVGRSSLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHSLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESMPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSTIAESAAMGDAYSFHYTTGDIRETSNSVPIGGDAMSPPQSSSDRGTSEEHHKEYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTVYEVCKLGTHSPQHSGGQIEQSPGKHLPSGLVLVECPDQLKSSGSHSVSINSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKILELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENESAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRSMPSSPSTLYSPHSKSSFTKGQPGNKKQSLVEQTGMDSSRGSLHLVRSISLVTVSQDSSLHLACQADLPATRPTSGEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQLTKEDSRHSVLSVSIVDYYGGTVQDKMSRGSKQAVRHETSGRDYEMDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQLTDKGDVS
Length1981
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.302
Instability index59.92
Isoelectric point5.77
Molecular weight215618.20
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22538
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     202.65|      51|      54|     469|     519|       1
---------------------------------------------------------------------------
  427-  462 (53.15/27.33)	.........VHQAFVRFSSKRMWS..QDWMGSSPWEAWPFWNFSP...SS......
  469-  519 (82.06/46.82)	FFGSSRGLGVNSNFLRLRRQRNSN..SNGMASSISSVSSTSNGSE...HAIAAKGG
  521-  575 (67.45/36.97)	LLADADSAACRQSDLPLNNDIAGSkvSKRSRSEITEVSSHA.GKEvnmQGTNGQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      24|      54|     948|     972|       2
---------------------------------------------------------------------------
  948-  972 (35.43/23.44)	LDSLSAKTFSgTSPSVQRQPIVELL
 1004- 1027 (45.56/26.08)	LDEQRRRGFS.CDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.72|      52|      54|     587|     639|       3
---------------------------------------------------------------------------
  587-  639 (89.72/66.48)	MDI.DILLSEFGdFSDF..FQEDELDFGEPPGTAESHALVPPASEYGDMPFIDSPS
  642-  696 (78.01/51.99)	MDIpEQRLSPVG.FTSMeaFNHHTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.38|      45|      57|    1681|    1737|       4
---------------------------------------------------------------------------
 1687- 1737 (63.20/59.00)	GIPSnSNGPTLEQQDMGLI...QDRSMP.SSPSTLysPHSKSsfTKGQpGNKKQS
 1743- 1791 (69.17/31.58)	GMDS.SRGSLHLVRSISLVtvsQDSSLHlACQADL..PATRP..TSGE.GNQSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      98.92|      24|      57|    1314|    1337|       5
---------------------------------------------------------------------------
 1314- 1337 (38.49/24.00)	VYVVCPFPEPSAVLQTL.VESSVAL
 1338- 1360 (28.49/15.63)	GSILSSERERKSFLYTQ.VAKALN.
 1373- 1397 (31.94/18.52)	VVMLSGFSIPKLVLQIVtVETLLRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.66|      11|      19|       7|      23|       6
---------------------------------------------------------------------------
    7-   17 (22.30/21.35)	PPVPAVAGGGE
   28-   38 (23.35/ 6.18)	PPLPACTTKGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     245.43|      87|     277|    1146|    1256|       8
---------------------------------------------------------------------------
 1080- 1186 (136.29/102.52)	DWCRGRSTIAESAAMGdAYSFHYTTGDIRET.SNSVPIGGDAMSPP...QSS.......................................................................................................................................................sdrgtseehhkeyhrvrpTIAVLPSPSLLVGYQDDWLKTSANCLKLWeKAPLEPYASAK
 1206- 1256 (55.40/31.73)	DFFMQLGTVYEVCKLG.THSPQHSGGQIEQSpGKHLPSGLVLVECPdqlKSS..................................................................................................................................................................................................................
 1426- 1465 (53.74/16.64)	....................................................gshsvsinsvteyfqalskswsvksflsslariikdikltlnistnqkessnipctvvyvvcpfpepsavlqtlvessvalgsilssererksflytqvakalnssasadeasasnvvmlsgfsipklvlqivtvetllrlhkpnelaafkdiaftvynkarriprfvsTSDMFQSPTYMSRPQSTMMHTASPGPTLW.KECLAPRMSGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.78|      18|      53|     756|     774|       9
---------------------------------------------------------------------------
  756-  774 (25.15/16.37)	QSSKVES....AGDKSEkSDKLT
  808-  829 (25.63/12.24)	QSCKGETsrpvSGETSF.SSSLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.55|      22|      24|     842|     864|      10
---------------------------------------------------------------------------
  842-  864 (32.93/24.82)	YFLLSMKTALATEIECiTFQAAM
  869-  890 (33.62/20.40)	HSLVSLRTKASAELKS.ALSSAM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.49|      15|      20|     895|     910|      12
---------------------------------------------------------------------------
  895-  910 (23.93/20.68)	SSNSDLvPKYDMKRKE
  917-  931 (26.56/17.29)	SSDVDH.EMYDRSRLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.53|      15|      27|     223|     242|      14
---------------------------------------------------------------------------
  223-  242 (19.94/21.36)	RNSLERALRGLSYarfgdVF
  252-  266 (27.58/14.66)	QNSFRRAQPTVEF.....VF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.46|      23|      24|     327|     349|      15
---------------------------------------------------------------------------
  327-  349 (39.74/24.28)	DLARQVYSSKLSAPNLPGFTQPT
  352-  374 (39.73/24.27)	QLRGQSYYVEVALGFPPASTDKT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.86|      22|     382|    1548|    1574|      16
---------------------------------------------------------------------------
 1548- 1574 (29.42/27.81)	SISGGTdsgASPLLegSENESAASLHC
 1933- 1954 (44.44/24.39)	SLSWMT...VSPVY..MERRSALPFHC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.96|      13|    1213|      80|      94|      18
---------------------------------------------------------------------------
   80-   94 (20.12/21.40)	IKAVSLpsTLNMWTN
 1290- 1302 (22.84/14.84)	IKDIKL..TLNISTN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22538 with Med13 domain of Kingdom Viridiplantae
Unable to open file!