<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22537

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPVEPDYSATSDRSSKAEQKDALNSTVLSAYLRLQNEGFLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSVPEMTQPAVAKLRVVSSGLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHIPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKTSESENNQIRKELDSVNDPHLGADGQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSPWEAWPFWNFSPSSYFRNSSFFGSSRGLGVNSNFLRLRRQRNSNSNGMASSISSVSSTSNGSEHAIAAKGGDLLADADSAACRQSDLPLNNDIAGSKVVSKRSRSEITEVSSHAGKEVNMQGTNGQGGCSWGWGEEGVVMDIDILLSEFGDFSDFFQEDELDFGEPPGTAESHALVPPASEYGDMPFIDSPSIAMDIPEQRLSPVGFTSMEAFNHHTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEATLTFAPEYAAVEISSCEMPTTLFTNPYLPRSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTAANLSRDVGRSSLYTLVQGRKKESEKSLNNADEQSCKGETSRPVSGETSFSSSLTLQKKSDNMLNVGYFLLSMKTALATEIECITFQAAMCRIRHSLVSLRTKASAELKSALSSAMQTESSSNSDLVPKYDMKRKESMPARLSSDVDHEMYDRSRLENVGVWRSVVVPKGAKPLDSLSAKTFSGTSPSVQRQPIVELLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDPLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSTIAESAAMGDAYSFHYTTGDIRETSNSVPIGGDAMSPPQSSSDRGTSEEHHKEYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTVYEVCKLGTHSPQHSGGQIEQSPGKHLPSGLVLVECPDQLKSSGSHSVSINSVTEYFQALSKSWSVKSFLSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVALGSILSSERERKSFLYTQVAKALNSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMMHTASPGPTLWKECLAPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKILELCAQDDRKYAFEPLFILAEPGAVDYNDTMESSRFGVDASSSRVYSSISGGTDSGASPLLEGSENESAASLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTTVLQSLFIQILQQGCQIMSSSPEASNTRSRDVVITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPSNSNGPTLEQQDMGLIQDRSMPSSPSTLYSPHSKSSFTKGQPGNKKQSLVEQTGMDSSRGSLHLVRSISLVTVSQDSSLHLACQADLPATRPTSGEGNQSSSTGASSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKQLTKEDSRHSVLSVSIVDYYGGTVQDKMSRGSKQAVRHETSGRDYEMDMHNVLEAVAAELHSLSWMTVSPVYMERRSALPFHCDMVLRLRRLLHYADRHLSQLTDKGDVS
Length1892
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.08
Grand average of hydropathy-0.303
Instability index59.73
Isoelectric point5.78
Molecular weight206744.39
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22537
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.28|      50|      54|     379|     429|       1
---------------------------------------------------------------------------
  379-  429 (78.01/54.26)	FFGSSRGLGVNSNFLRLRRQRNSN...SNGMASSISSVSSTSnGSE...HAIAAKGG
  431-  486 (72.27/45.25)	LLADADSAACRQSDLPLNNDIAGSkvvSKRSRSEITEVSSHA.GKEvnmQGTNGQGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.00|      24|      54|     859|     883|       2
---------------------------------------------------------------------------
  859-  883 (35.43/23.13)	LDSLSAKTFSgTSPSVQRQPIVELL
  915-  938 (45.56/25.71)	LDEQRRRGFS.CDPSMVHAGCGGLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.72|      52|      54|     498|     550|       3
---------------------------------------------------------------------------
  498-  550 (89.72/60.35)	MDI.DILLSEFGdFSDF..FQEDELDFGEPPGTAESHALVPPASEYGDMPFIDSPS
  553-  607 (78.01/47.21)	MDIpEQRLSPVG.FTSMeaFNHHTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     132.38|      45|      57|    1592|    1648|       4
---------------------------------------------------------------------------
 1598- 1648 (63.20/54.80)	GIPSnSNGPTLEQQDMGLI...QDRSMP.SSPSTLysPHSKSsfTKGQpGNKKQS
 1654- 1702 (69.17/29.37)	GMDS.SRGSLHLVRSISLVtvsQDSSLHlACQADL..PATRP..TSGE.GNQSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     188.57|      48|     203|    1134|    1188|       9
---------------------------------------------------------------------------
 1134- 1184 (76.30/49.91)	HSPQHSGGQIEQSPGKHL..PSGLVLVECP......DQLKSSGShsvSINSVTEYFQAL
 1342- 1388 (74.34/40.71)	QSPTYMSR..PQSTMMHTasPGPTLWKECL......AP.RMSGQ...TLSRETEFDASM
 1406- 1445 (37.93/17.90)	PDPSKILELCAQDDRKYA..FEPLFILAEPgavdynDTMESS.................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.19|      22|      22|     238|     259|      10
---------------------------------------------------------------------------
  238-  259 (38.10/24.20)	LARQVYSSKLSAPNLPGFTQPT
  263-  284 (38.09/24.19)	LRGQSYYVEVALGFPPASTDKT
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22537 with Med13 domain of Kingdom Viridiplantae
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