<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22492

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVARQAAEESYLALRELVEKSRAGAEGEAAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFIQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERKPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGENTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKINYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISRSPTDVVLKRKEVHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKRSITPTEVFVSLKTRSILQLFAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHIDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPGHSEIDESLPLKPSFSSVVNAVLGYERDSPSKENWLSYSSPSTHLSSQKVGRQGVSSRAGPPELDDELLHSNIDTAKVASGVTLDSYLLSNSKSANSTETSVSVPAGLENISALRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEDASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGLGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYGALWELHGGSNTTEWGSHVRIANTSEMDSHISFDYDGVTLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRIKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWDASKAGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVCGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGWTGHGLVPSSLMPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMEHVAQGLNTLEPSFLNARHTSANTSSGSQQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQAPQSSAQGELTPSEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHVRTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGRSCWLQHEDWERCKQSVVKAVKMVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGSTRP
Length1625
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.218
Instability index50.29
Isoelectric point7.05
Molecular weight180272.58
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22492
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.09|      73|     117|    1083|    1163|       1
---------------------------------------------------------------------------
 1083- 1163 (109.28/84.63)	GPllSLGGAI.....RPAKMPAVPAvcGSAQKQNNVLLANGSSSTTvhiNSHDAQTSSMLSAVG....WTGHGlVPSSLMP.FDVSVVLRG
 1198- 1280 (112.80/64.87)	GP..SIGGSLpcpqfRPFIMEHVAQ..GLNTLEPSFLNARHTSANT...SSGSQQIAASVSRAGnatlPSGDG.APAHLSPdTNLPVHMKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     263.27|      66|     117|     626|     693|       2
---------------------------------------------------------------------------
  626-  693 (103.28/88.06)	EKLQVLQSmEDGSpGHSEIDESLPLK.PSFS.SVVNAV.........LGYERDSPSKENWLSYS...SPSTHLSSQKVGRQG
  748-  811 (92.46/67.64)	ENISALRS.EVPS.GKRYLSEFLLNI.PSLQrSIISG...........GPRKRRKLPEDASSVQ...SRTT.LTYGTILREG
  823-  887 (67.52/46.86)	VLLQVI.K.......HC....SLRIKyAQLT.TQMNSLnipyveevgLG....TPSSNLWLRLPfaqDGSWKHTCLRLGEAG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.34|      18|     118|     583|     600|       3
---------------------------------------------------------------------------
  583-  600 (31.62/18.72)	IDGE.DRSNIDTTTDAKEV
  703-  721 (26.72/14.80)	LDDElLHSNIDTAKVASGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     163.11|      56|     146|      11|      71|       4
---------------------------------------------------------------------------
   11-   71 (72.84/62.21)	ELGTVARQAAEESyLALRELVEKSraGAEGEAAQQrSDTEKKIdLLKFIDRTRQRMLR.LHV
  162-  218 (90.26/55.02)	KLSTLVRAKLLET.LVPKEMSEVS..VTDGIANVQ.VDGEFKV.LLTLGYRGHFSLWRiLHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.42|      15|      15|     504|     518|       6
---------------------------------------------------------------------------
  504-  518 (24.13/17.00)	TEVFVSLKTRSILQL
  522-  536 (27.29/20.34)	TGRFLGLKVYSECQI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.55|      15|      19|     940|     954|       7
---------------------------------------------------------------------------
  940-  954 (24.85/15.18)	LTYNSVEADSIQRLV
  960-  974 (26.69/16.83)	LSNARVFACGMRRLV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     116.22|      28|     261|    1285|    1314|       8
---------------------------------------------------------------------------
 1285- 1314 (45.17/28.21)	AFIGLgdDGGYGG..GWV...PHAALKKVLRGILK
 1316- 1338 (21.75/ 7.15)	..LGV..........LWLfaqLRDILKDILGSVLK
 1547- 1576 (49.29/25.02)	AYLAM..DGSHGGrsCWL...QHEDWERCKQSVVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      31.04|      10|      15|     347|     357|      11
---------------------------------------------------------------------------
  347-  357 (13.30/11.41)	SPFIkVEALQD
  365-  374 (17.74/ 9.91)	SSFV.LDPLTD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22492 with Med14 domain of Kingdom Viridiplantae
Unable to open file!