<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22478

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVARQAAEESYLALRELVEKSRAGAEGEAAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFTQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERRPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGEKTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKVNYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISRSPTDVVLKRKEDHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKQSITPTEVFVSLKTRSILHLFAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHTDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPRHSEIDESLLLKPSFSSVVNTVLGYEQDSPSKENWLSYSSPSTHLSSQKVGRQGVSSRAGPPELDDDLLHSNIDTAKVASGVTLDSYLLSNSKSAYSTETSGLVPAGFENISTLRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEVASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGLGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYGALWELHGGSNTTEWGSRVRIANTSEMDSHISFDYDGITLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRVKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWEAGKVGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVCGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGRTGHGLVPSSLMPFDVSAVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMELVAQGLNTLEPSFLNARHTSANTSSGSQQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQQQAPQSSAQGELTPFEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHARTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGWSCWLQHEDWERCEQSVVKAVKTVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGSTRP
Length1627
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index50.09
Isoelectric point6.95
Molecular weight180695.93
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22478
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     716.60|     185|     194|     609|     802|       1
---------------------------------------------------------------------------
  609-  798 (293.98/222.11)	GQMqLGEDE.CIANL.LDVEKLQVLQSMEDGSPRHSEIDESLLLK.PSFS......SVVNTV.LGYEQD....SPSKENWLSYS...S..PSTHLSSQKVGRQGVSS.......RAGPPELDDDL..LHSNIDTAK.............................VASGVTLDSYLLSnsksAYSTETSGLVPAG...FENIS.TLRS.EVPSGKR..YLSEFLLNIPSLQRSIISGGPRK..RRK.LPEVASSV...QS
  805-  980 (198.46/141.97)	GTI.LREGNcCITEN.IYASVL..LQVI.....KHC....SLRIKyAQLT......TQMNSLnIPYVEEvglgTPSSNLWLRLPfaqD..GSWKHTCLRLGEAGSMS....wgvRINDPYY.GALweLHGGSNTTE.............................WGSRVRI..........ANTSEMDSHISFD...YDGITlTYNSvEADSIQR..LVSE..LRRLSNAR.VFACGMRRlvRVK.VDE..........
  982- 1210 (224.15/158.12)	....LVENQ.LATKAkLHARK.GFRNRLSDQMAKNFRINAVGLMN.LWFSyganamPMVHFV.VEWEAG....KVGCTMRISPD...HlwPHTKFLEDFVNCNEVASfldcirlTAG.PLLS.....LGGAIRPAKmpavpavcgsaqkqnnvllangsssttvhINSHDAQTSSMLS....AVGRTGHGLVPSSlmpFDVSA.VLRG...PYWIRiiYRNKFSVDMRCFAGDQVWLQPAT..PPKgGPSIGGSLpcpQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     488.16|     159|    1302|      64|     241|       2
---------------------------------------------------------------------------
   64-  241 (243.61/204.14)	QRM.LRLHVLakwcqQVPLLHYCQQLASTLSSHETcfTQTGDSLFFMHEGLQQ.ARAPIFDVSSAIEVIHTGSYRRLPKSV.EE...IGTQNTLFQD........ERRptlkklstlvRAKLLETLVPKEMSEVSVTDGI...ANVQVD.GEFKVLLTLGYRGHFSLwrILHIELLVGEKTGPIKLEETRRYVLGD
 1368- 1544 (244.55/160.81)	QRVqLHLQVL.....NVKRFHHQQQQQQQQAPQSS..AQGELTPFEIHEICDYfSRCVVCEPYDASRIASFIMLLTLPISViQEfvkLITWNKSLSEahgdiaaaERA..........RAELCLEKHPRSVSDDYTEPSLlskSNIQHDrANNSVDFTLTFVLDHNL..TPHARTSGGAAWLPFCVSLRLRYTFGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.57|      28|     261|    1285|    1314|       3
---------------------------------------------------------------------------
 1285- 1314 (45.91/27.63)	AFIGLgdDGGYGG..GWVPHAALKKVLRGILK
 1549- 1578 (50.67/24.97)	AYLAM..DGSHGGwsCWLQHEDWERCEQSVVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.01|      11|      15|     504|     514|       5
---------------------------------------------------------------------------
  504-  514 (18.32/10.79)	TEVFVSLKTRS
  522-  532 (19.69/12.17)	TGRFLGLKVYS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22478 with Med14 domain of Kingdom Viridiplantae
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