<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22474

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVARQAAEESYLALRELVEKSRAGAEGEAAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFTQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERRPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGEKTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKVNYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISRSPTDVVLKRKEDHMDVLQKRVDRRGFENCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAVLDSEEALNKQSITPTEVFVSLKTRSILHLFAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHTDGEDRSNIDTTTDAKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPRHSEIDESLLLKPSFSSVVNTVLGYEQDSPSKENWLSYSSPSTHLSSQKVGRQGVSSRAGPPELDDDLLHSNIDTAKVASGVTLDSYLLSNSKSAYSTETSGLVPAGFENISTLRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEVASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGLGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYGALWELHGGSNTTEWGSRVRIANTSEMDSHISFDYDGITLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRVKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWEAGKVGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVCGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGRTGHGLVPSSLMPFDVSAVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMELVAQGLNTLEPSFLNARHTSANTSSGSQQAVTTTNRLSGGAPGEIKLTSGVGCQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGLGDDGGYGGGWVPHAALKKVLRGILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQQQAPQSSAQGELTPFEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERARAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHARTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGWSCWLQHEDWERCEQSVVKAVKTVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGSTRP
Length1652
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.223
Instability index49.35
Isoelectric point7.04
Molecular weight183095.61
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22474
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     537.71|     169|     194|     609|     802|       1
---------------------------------------------------------------------------
  609-  791 (263.26/200.85)	GQMQL..GEDE.CIANLLDVEKLQVLQSMEDGSPRHSEIDESLLLK.PSFSSVVNTV.LGYEQD....SPSKENWLSYS...SPSTHLSSQKVGRQGVSS...RAGPPELdDDL..LHSNIDTAKVASGVTLdsyllsnsksAYSTETSGLVPAGFENIS.TLRS.EVPSGKRYLSEflLNIPSLQRsIISGGPRK..RRKLPE
  805-  980 (222.85/128.63)	GTI.L..REGNcCITENIYASVL..LQVI.....KHC....SLRIKyAQLTTQMNSLnIPYVEEvglgTPSSNLWLRLPfaqDGSWKHTCLRLGEAGSMSwgvRINDPYY.GALweLHGGSNTTEWGSRVRI..........ANTSEMDSHISFDYDGITlTYNSvEADSIQRLVSE..LRRLSNAR.VFACGMRRlvRVKVDE
 1259- 1324 (51.60/18.21)	GEIKLtsGVGC.QIAASVSRAGNATLPS.GDGAPAHLSPDTNLPVH...MKGELNTAfIGLGDD....GGYGGGW.................................................................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     211.99|      68|     832|     275|     349|       2
---------------------------------------------------------------------------
  275-  349 (107.68/89.27)	RQTNV.LRQGRWKEAIKselvSDSHRSAGQGGNNAPTQLGQdGELDSS..GFRIPG.LKVNYWLD..ERNSGSAesDSSPF
 1109- 1182 (104.31/67.62)	KQNNVlLANGSSSTTVH....INSHDAQTSSMLSAVGRTGH.GLVPSSlmPFDVSAvLRGPYWIRiiYRNKFSV..DMRCF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     488.16|     159|    1327|      64|     241|       6
---------------------------------------------------------------------------
   64-  241 (243.61/177.06)	QRM.LRLHVLakwcqQVPLLHYCQQLASTLSSHETcfTQTGDSLFFMHEGLQQ.ARAPIFDVSSAIEVIHTGSYRRLPKSV.EE...IGTQNTLFQD........ERRptlkklstlvRAKLLETLVPKEMSEVSVTDGI...ANVQVD.GEFKVLLTLGYRGHFSLwrILHIELLVGEKTGPIKLEETRRYVLGD
 1393- 1569 (244.55/139.48)	QRVqLHLQVL.....NVKRFHHQQQQQQQQAPQSS..AQGELTPFEIHEICDYfSRCVVCEPYDASRIASFIMLLTLPISViQEfvkLITWNKSLSEahgdiaaaERA..........RAELCLEKHPRSVSDDYTEPSLlskSNIQHDrANNSVDFTLTFVLDHNL..TPHARTSGGAAWLPFCVSLRLRYTFGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22474 with Med14 domain of Kingdom Viridiplantae
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