<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22464

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMWTNIFKIGELQTVSWFQFLPVEPEYNATSDRSSKAEQKDALNSTVLSAYLRLQSEGLLSTWTNSFVGPWDPSQGEHNPDEKIKLWLFLSGRHSSLPEMTQPAVAKLRVVSSDLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKEFDSVKDLHLGDDVQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSFFGSSRALGVNSNFLRLRRQRNNNSNGMTSSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVSENMQGTNGQGGCSWGWGEEGVVMDINILLLEFGDFSDFFQEDELDFGEPPGTAESHALVSPASEFGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEAALTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNSADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLENVGVWRSVVVPKGAKPLDSLSTKTFTGISPSVQRQPIVKLLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDLLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRDTSNSIPIGGDAMSPPKSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQVEQSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVAIGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMLHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDIMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPPNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQSGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLIATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIVDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYTERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGEM
Length1905
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.08
Grand average of hydropathy-0.297
Instability index58.94
Isoelectric point5.79
Molecular weight208079.99
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22464
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.96|     117|     125|    1254|    1378|       1
---------------------------------------------------------------------------
 1254- 1378 (186.61/121.89)	LSSERErksFLYTQVAKALDSSASADEAsasnVVMLSGFSIPKLVLQ...IVTVETLLRLHKPNeLAAFKDIA....FTVYNKARRIPRFVS.TSDMFQSPTYM.SRPQS.TMLHTASPGPTLWK..ECLVPRMSGQ
 1380- 1508 (186.35/104.45)	LSRETE...FDASMRSVSWDNSWQPGRA....VGLPDPSKIPELCAQddrKYAFEPLFILAEPG.TADYSDIMessrFGADASSSRAYSSISgGTDSGASPPLEgSENDSgTSLHCCYGWTEDWRwlVCIWTDSRGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     187.11|      55|     125|      96|     164|       2
---------------------------------------------------------------------------
   96-  150 (91.70/84.01)	LPEMTQPAVAKLRVVSSDLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGD
  252-  306 (95.41/57.90)	LPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKEFDSVKDLHLGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.81|      22|      54|     337|     358|       3
---------------------------------------------------------------------------
  337-  358 (42.49/27.28)	VHQAFVRFSSKRMWSQDWMGSS
  388-  409 (38.32/23.82)	VNSNFLRLRRQRNNNSNGMTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|    1752|    1797|       4
---------------------------------------------------------------------------
 1752- 1797 (63.23/55.06)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
 1808- 1849 (67.08/45.57)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.97|      52|     125|     993|    1044|       6
---------------------------------------------------------------------------
  993- 1044 (86.79/54.82)	DWCRGRSNIAESAAMGDAYSF..HYTTGDIRDTSNS.IPIGGDAMSPPKSSNDRG
 1048- 1101 (77.47/47.98)	EHHKGYHRVRPTIAVLPSPSLlvGYQDDWLKTSANC.LKLWEKAPLEPYASAKPV
 1119- 1170 (76.71/47.42)	DFFMQLGTIYEVCKLG.THSP..QHSGGQVEQSPGKyLPSGLVLVECPDQLKTRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.04|      37|      56|    1580|    1620|      11
---------------------------------------------------------------------------
 1580- 1620 (57.78/45.64)	SF.GGNEVKKWPVQLRRSipdGIpPNSNGPTLQQQDMGLI...QD
 1638- 1678 (52.26/28.82)	SFtKGQSGNKKQILVEQS...GM.DSSRGSLHLVRSISLVavsQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.65|      27|     388|     431|     462|      12
---------------------------------------------------------------------------
  431-  457 (46.99/35.69)	LLADADSTACHQSDLP..LNNDIAGSKMV
  939-  967 (41.66/20.01)	LLGTCHSKDCAGVDLVdlLSAEVSESSMI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.13|      19|     276|     365|     384|      14
---------------------------------------------------------------------------
  365-  384 (35.19/22.89)	FWN.FSPSSYFRNSSFFgSSR
  642-  661 (33.94/17.10)	FTNpYLPGSKKRGSCGF.SSR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.20|      44|     388|     782|     833|      15
---------------------------------------------------------------------------
  698-  741 (71.51/39.28)	SSLYTLVQGRKNESEKSLNSA..DEQSC......KGETSRPVSGETSFSSSL
  782-  833 (59.69/49.11)	HTLVSLRTKASAELKSALSSAmqTESSSnsglvpKYEMKRKESIPARLSSDV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22464 with Med13 domain of Kingdom Viridiplantae
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