<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22462

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTQPAVAKLRVVSSDLWVAPGNSEEVAAALCQALRNSLERALRGLSYARFGDVFTKYNPPTRNQNSFRRAQPTVEFVFAATEEAIFVHVIISARYMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGRLVGCCPSDLARQVYSSKLSAPNLPGFTQPTICQLRGQSYYVEVALGFPPASTDKISESENNQIKKEFDSVKDLHLGDDVQQKLESADGLPVLERTFIYPPEAVMVPMVHQAFVRFSSKRMWSQDWMGSSSWEAWPFWNFSPSSYFRNSSSFFGSSRALGVNSNFLRLRRQRNNNSNGMTSSISSVSSTSNGSEHAVAAKGGDLLADADSTACHQSDLPLNNDIAGSKMVSKRSRSEITEDSSHAGKEVSENMQGTNGQGGCSWGWGEEGVVMDINILLLEFGDFSDFFQEDELDFGEPPGTAESHALVSPASEFGDMPFIDSPSVAMDIPEQRLSPVGFTSMEAFNHQTMSPIQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRAEAALTFAPEYAAVEISSCETPATLFTNPYLPGSKKRGSCGFSSRVYSYDVTQSSKVESAGDKSEKSDKLTPANLSRDVGRSSLYTLVQGRKNESEKSLNSADEQSCKGETSRPVSGETSFSSSLTIQKKSDSMLNVGYFLLSMKTALATEIECITFQAAMCRIRHTLVSLRTKASAELKSALSSAMQTESSSNSGLVPKYEMKRKESIPARLSSDVDHDMYDRSQLENVGVWRSVVVPKGAKPLDSLSTKTFTGISPSVQRQPIVKLLSAMALLVQQSTSFVDIALDMDDGDGSFFWLSLDEQRRRGFSCDPSMVHAGCGGLLGTCHSKDCAGVDLVDLLSAEVSESSMIGLLQSDIKSALKTAFANMDGPLSVIDWCRGRSNIAESAAMGDAYSFHYTTGDIRDTSNSIPIGGDAMSPPKSSNDRGTSEEHHKGYHRVRPTIAVLPSPSLLVGYQDDWLKTSANCLKLWEKAPLEPYASAKPVTYYALCPDIDMLTSAATDFFMQLGTIYEVCKLGTHSPQHSGGQVEQSPGKYLPSGLVLVECPDQLKTRGSHSVSISSVTEYFQALSKSWSVKSFVSSLARIIKDIKLTLNISTNQKESSNIPCTVVYVVCPFPEPSAVLQTLVESSVAIGSILSSERERKSFLYTQVAKALDSSASADEASASNVVMLSGFSIPKLVLQIVTVETLLRLHKPNELAAFKDIAFTVYNKARRIPRFVSTSDMFQSPTYMSRPQSTMLHTASPGPTLWKECLVPRMSGQTLSRETEFDASMRSVSWDNSWQPGRAVGLPDPSKIPELCAQDDRKYAFEPLFILAEPGTADYSDIMESSRFGADASSSRAYSSISGGTDSGASPPLEGSENDSGTSLHCCYGWTEDWRWLVCIWTDSRGELLDSLIFPFGGISSRQDTKVLQSLFIQILQQGCQIMSSSPEASNTRSRDVIITRIGGFLELEIQEWQKAIYSFGGNEVKKWPVQLRRSIPDGIPPNSNGPTLQQQDMGLIQDRNMPSSPSTLYSPHSKSSFTKGQSGNKKQILVEQSGMDSSRGSLHLVRSISLVAVSQDSSLHLACQADLIATRPTSGEGNQSSTGSSSYLDGFAPVKSIGSMSASYLLVPSPSMRYLSPATLQLPTCLTSESPPLAHLLHSKGTATPLAMGYVVSKAVPPVRKNAAQLTKEDRHSVLSVSIVDYYGGSTPTVQEKMSRGVGGSTMSKQARNITHETSARDYEMDMHNVLEAVAAELHALSWMTVSPVYTERRSALPFHCDMVLRLRRLLHYADRHLSQLTEKGEM
Length1808
PositionKinase
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.285
Instability index59.80
Isoelectric point5.86
Molecular weight196969.71
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22462
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     372.96|     117|     125|    1157|    1281|       1
---------------------------------------------------------------------------
 1157- 1281 (186.61/132.47)	LSSERErksFLYTQVAKALDSSASADEAsasnVVMLSGFSIPKLVLQ...IVTVETLLRLHKPNeLAAFKDIA....FTVYNKARRIPRFVS.TSDMFQSPTYM.SRPQS.TMLHTASPGPTLWK..ECLVPRMSGQ
 1283- 1411 (186.35/113.53)	LSRETE...FDASMRSVSWDNSWQPGRA....VGLPDPSKIPELCAQddrKYAFEPLFILAEPG.TADYSDIMessrFGADASSSRAYSSISgGTDSGASPPLEgSENDSgTSLHCCYGWTEDWRwlVCIWTDSRGE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.81|      22|      54|     239|     260|       2
---------------------------------------------------------------------------
  239-  260 (42.49/31.75)	VHQAFVRFSSKRMWSQDWMGSS
  291-  312 (38.32/27.74)	VNSNFLRLRRQRNNNSNGMTSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.31|      41|      54|    1655|    1700|       3
---------------------------------------------------------------------------
 1655- 1700 (63.23/45.48)	SPPLAHLLHSKGTAtplamGYVVSKAVPPV.RKNAAQLTKEDRHSVL
 1711- 1752 (67.08/37.63)	STPTVQEKMSRGVG.....GSTMSKQARNItHETSARDYEMDMHNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.47|      23|     125|      42|      66|       5
---------------------------------------------------------------------------
   42-   66 (38.51/29.69)	LRGLSYarFGDVFTKYNPPTRNQNS
  165-  187 (40.96/25.08)	LRGQSY..YVEVALGFPPASTDKIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     240.97|      52|     125|     896|     947|       6
---------------------------------------------------------------------------
  896-  947 (86.79/51.43)	DWCRGRSNIAESAAMGDAYSF..HYTTGDIRDTSNS.IPIGGDAMSPPKSSNDRG
  951- 1004 (77.47/45.01)	EHHKGYHRVRPTIAVLPSPSLlvGYQDDWLKTSANC.LKLWEKAPLEPYASAKPV
 1022- 1073 (76.71/44.49)	DFFMQLGTIYEVCKLG.THSP..QHSGGQVEQSPGKyLPSGLVLVECPDQLKTRG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     277.18|      89|     395|      68|     163|       8
---------------------------------------------------------------------------
   68-  163 (135.72/91.65)	RRAQPtVEFvfaATEEAiFVHVIISAryMRNLSSDDIEKVLTHTPRSVGEGLPVIVAPSGMLGR...LVGCCPSDLARQVYSSKLSA.....PNLPGFTQPTIC
  463-  559 (141.46/76.11)	QRLSP.VGF...TSMEA.FNHQTMSP..IQDVASKVQEPLKEIASPAGSQSLVLSSSRSDFLTRaeaALTFAPEYAAVEISSCETPAtlftnPYLPGSKKRGSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     110.04|      37|      56|    1483|    1523|      11
---------------------------------------------------------------------------
 1483- 1523 (57.78/49.67)	SF.GGNEVKKWPVQLRRSipdGIpPNSNGPTLQQQDMGLI...QD
 1541- 1581 (52.26/31.35)	SFtKGQSGNKKQILVEQS...GM.DSSRGSLHLVRSISLVavsQD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22462 with Med13 domain of Kingdom Viridiplantae
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