<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22453

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAGELGQQTVELGTVSRQAAEESYLALRELVEKSRAGVEGETAQQRSDTEKKIDLLKFIDRTRQRMLRLHVLAKWCQQVPLLHYCQQLASTLSSHETCFTQTGDSLFFMHEGLQQARAPIFDVSSAIEVIHTGSYRRLPKSVEEIGTQNTLFQDERKPTLKKLSTLVRAKLLETLVPKEMSEVSVTDGIANVQVDGEFKVLLTLGYRGHFSLWRILHIELLVGENTGPIKLEETRRYVLGDDIERRMAVADNPLTILYTILHELCISFVMDTVIRQTNVLRQGRWKEAIKSELVSDSHRSAGQGGNNAPTQLGQDGELDSSGFRIPGLKINYWLDERNSGSAESDSSPFIKVEALQDMQIKCQHSSFVLDPLTDKEADLSLDLSCIDVEAIILKAIACNRHTRLLEIQRELKKNTRISLSPTDVVLKRKEVHMDVLQKRVDRRGFKNCCTNEVLQVRAYGKSYIHLGINIRSGGFLLQSPKNILPPSAALDSEEALNKRSITPTEVFVSLKTRSILQLFAATGRFLGLKVYSECQITLKIPKSILYGSDFMVMGFPWRTNAYYLLMQLDDNLMPVFYLLEVHIDGEDRFNIDTTTDTKEVVRFNRIDIGQMQLGEDECIANLLDVEKLQVLQSMEDGSPRHSEIDESLPLKPSFSSVVKAVLGYERDSPSKENWLSYSSPSTHLSSQKVVRQGVSGRAGPPELDDELLHSNIDTAKVTSGVTLDSYLLSNLESAYSTETSVLVPAGLENISALRSEVPSGKRYLSEFLLNIPSLQRSIISGGPRKRRKLPEDASSVQSRTTLTYGTILREGNCCITENIYASVLLQVIKHCSLRIKYAQLTTQMNSLNIPYVEEVGQGTPSSNLWLRLPFAQDGSWKHTCLRLGEAGSMSWGVRINDPYYAALWELHGGSNTTEWGSRVRIANTSEMDSHISFDYDGVTLTYNSVEADSIQRLVSELRRLSNARVFACGMRRLVRVKVDEKLVENQLATKAKLHARKGFRNRLSDQMAKNFRINAVGLMNLWFSYGANAMPMVHFVVEWEAGKVGCTMRISPDHLWPHTKFLEDFVNCNEVASFLDCIRLTAGPLLSLGGAIRPAKMPAVPAVWGSAQKQNNVLLANGSSSTTVHINSHDAQTSSMLSAVGRTGHGLVPSSLMPFDVSVVLRGPYWIRIIYRNKFSVDMRCFAGDQVWLQPATPPKGGPSIGGSLPCPQFRPFIMELVAQGLNTLEPSFLNARHTSANTSSGSQQIAASVSRAGNATLPSGDGAPAHLSPDTNLPVHMKGELNTAFIGHGDDGGYGGGWVPHAALKKVLRDILKYLGVLWLFAQLRDILKDILGSVLKDNEGALLNLDQEQPALRFFVGGYVFAVSVQRVQLHLQVLNVKRFHHQQQQQQAPQSSAQGELTPSEIHEICDYFSRCVVCEPYDASRIASFIMLLTLPISVIQEFVKLITWNKSLSEAHGDIAAAERAQAELCLEKHPRSVSDDYTEPSLLSKSNIQHDRANNSVDFTLTFVLDHNLTPHVRTSGGAAWLPFCVSLRLRYTFGDTSHIAYLAMDGSHGGRSCWLQHEDWERCKQSVVKAVKTVNGSPAGGETSRGRLQMVAEMVQKQLQLCLVHLRDGSLSAGST
Length1623
PositionTail
OrganismTriticum aestivum (Wheat)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> Liliopsida> Poales> Poaceae> BOP clade> Pooideae> Triticodae> Triticeae> Triticinae> Triticum.
Aromaticity0.07
Grand average of hydropathy-0.219
Instability index49.52
Isoelectric point7.05
Molecular weight180455.86
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22453
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     279.20|      80|     256|    1226|    1314|       1
---------------------------------------------------------------------------
  636-  691 (52.32/23.89)	..........................................DGSPRHSEIDESLPLKPSfSSV.VKAVLGYERDSPSKE..NWLSysspstHLSSQKVVR
 1226- 1310 (134.89/106.12)	EPSFL...NARHTSANTSsgsqqIAASVSRAGNATL.P..SGDGAPAHLSPDTNLPVHMK.GEL.NTAFIGHGDDGGYGG..GWVP......HAALKKVLR
 1485- 1564 (91.99/57.18)	EPSLLsksNIQHDRANNS.....VDFTLTFVLDHNLtPhvRTSGGAAWLPFCVSLRLRYTfGDTsHIAYLAM..DGSHGGrsCWLQ......H........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.73|       9|     377|     442|     452|       3
---------------------------------------------------------------------------
  442-  452 (15.74/16.31)	RRGfkNCCTNE
  809-  817 (19.99/11.93)	REG..NCCITE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.55|      16|      19|     747|     762|       5
---------------------------------------------------------------------------
  747-  762 (27.85/14.11)	LENISAL.RSEVPSGKR
  768-  784 (24.71/11.75)	LLNIPSLqRSIISGGPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.75|      18|     377|     698|     716|       6
---------------------------------------------------------------------------
  697-  715 (27.03/19.27)	RAGPPE.LDDELLhSNIDTA
  716-  734 (24.72/12.12)	KVTSGVtLDSYLL.SNLESA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.93|      18|     377|     990|    1008|       7
---------------------------------------------------------------------------
  963-  983 (21.96/10.20)	ARVFAcgmRRLVRVKVDEKLV
  991- 1008 (29.96/19.85)	AKLHA...RKGFRNRLSDQMA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.63|      24|     256|     857|     900|      11
---------------------------------------------------------------------------
  829-  852 (41.34/15.20)	KHCSLRIKYAQLTTQMNSLNIPYV
  877-  900 (46.29/62.90)	KHTCLRLGEAGSMSWGVRINDPYY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22453 with Med14 domain of Kingdom Viridiplantae
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