<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22400

Description Clock circadian regulator a
SequenceMFFPLFCSLLFSFVDDSSIFDGLMEEDEKDKAKRESRNKSEKKRRDQFNVLIKELGTMLPGNTRKMDKSTILQKSIDFLHKHKEIAAQSESTEIRQDWKPPFLSNEEFTQLMLEALDGFFLAIMTDGNIIYVSENVTSLLEHLPSDLVDQNLLNFLPSGEHSDVYKALSSHVTEGETLTPEYLKSKLNQLEFCCHMLRGTIDPKEPPVYEFVKFIGNFKSLNNVPNCNRNGFDGVIQRSLHSTFEDRVCLIATVRLAKPQFLKEMCTVEEPNEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHVDDLETLAKCHEHLMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTHTVVSYAEVRAEQRRELGIEDCPPEVAADKSQDSGSESQLNASSLKEALERFNHSRTPSASSRSSHKSSHTAVSDPASSQMKMQGDRSTPGRQSVSAVEMTSQRRSSVSSQSVQYSNQLEAMQHLKEQLEKKTRMIEDNIQRQLDELRQIQVELERVHGQSLQMFQQKGDEGLNLSSAHSPHGTAGQQGATMSMQGQVVPPAALQNNMQQQQAVQTQTQSQQQTLLRDQSTVMSQSQRSTLTLQPQQNPLSGSLYNTMMIPQQSQANMVQISTSLAQNTGPSNTAVATFAQDRSAQIRSPQLLTKLVTGQIPMGAVMVPTSMFMGQVVTAFAPQQGQTQTISISQQQEQQQQIQVQNQVSALQAGQASLAAFLCLTDLNVALQAPRLLHGNQSTQLILQAAFPLQQHSTFSAAAQQQQHQHHQLAAHRSDSLSDRPSTQPQ
Length812
PositionKinase
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.07
Grand average of hydropathy-0.562
Instability index57.51
Isoelectric point6.12
Molecular weight91568.88
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
cytoplasm	GO:0005737	IEA:InterPro
nucleus	GO:0005634	IEA:InterPro
transcription regulator complex	GO:0005667	IEA:InterPro

GO - Biological Function
DNA binding	GO:0003677	IEA:UniProtKB-KW
DNA-binding transcription factor activity	GO:0003700	IEA:InterPro
protein dimerization activity	GO:0046983	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22400
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.35|      16|      16|     590|     605|       1
---------------------------------------------------------------------------
  590-  605 (28.37/17.05)	QSQQQTL.LRDQSTVMS
  606-  622 (24.97/13.97)	QSQRSTLtLQPQQNPLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      29.57|      14|      16|     450|     465|       2
---------------------------------------------------------------------------
  458-  474 ( 9.12/12.16)	RsTPGrQSvSAV.EMTSQ
  527-  541 (20.45/11.20)	R.VHG.QS.LQMfQQKGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.96|      13|      16|     705|     718|       3
---------------------------------------------------------------------------
  705-  718 (18.85/14.20)	QQGQTQTiSISQQQ
  722-  734 (22.11/11.77)	QQIQVQN.QVSALQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.55|      13|      15|     379|     391|       5
---------------------------------------------------------------------------
  379-  391 (21.38/12.55)	EVRAEQRRELGIE
  396-  408 (21.18/12.37)	EVAADKSQDSGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.55|      13|      78|     410|     422|       7
---------------------------------------------------------------------------
  410-  422 (21.86/15.05)	QLNA.SSLKEALER
  489-  502 (18.69/11.72)	QLEAmQHLKEQLEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.94|      21|     153|     633|     653|       8
---------------------------------------------------------------------------
  624-  644 (34.09/23.58)	SLYNTMMIPQQSQANMVQIST
  645-  665 (33.85/23.35)	SLAQNTGPSNTAVATFAQDRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     111.40|      31|     203|     544|     588|       9
---------------------------------------------------------------------------
  425-  455 (54.20/27.24)	HSRTPSASSRSSHKSSHTAVSDPASSQMKMQ
  550-  580 (57.20/43.43)	HSPHGTAGQQGATMSMQGQVVPPAALQNNMQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22400 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ERVHGQSLQMFQQKGDEGLNLSSAHSPHGTAGQQGATMSMQGQVVPPAALQNNMQQQQAVQTQTQSQQQTLLRDQSTVMSQSQRSTLTLQPQQNPLSGSLYNTMM
2) LGIEDCPPEVAADKSQDSGSESQLNASSLKEALERFNHSRTPSASSRSSHKSSHTAVSDPASSQMKMQGDRSTPGRQSVSAVEMTSQRRSSVSSQSVQYSNQLEAMQHLKEQLEKKTRMIEDNIQRQLDELRQIQVE
3) TFSAAAQQQQHQHHQLAAHRSDSLSDRPSTQPQ
526
388
780
630
524
812










Molecular Recognition Features






MoRF SequenceStartStop




NANANA