<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22398

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVPLGGPVVSGPQPPPPGTPATQGVKLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPALPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLKFWLGEQRCRQSVKHLPTVCSDIVHLSNSATHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQVEGEDGPMCAQLLQLFKPNLEHLVQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEGVQVEGDGSSHAIRLLKIPPCRDVGEETRRALERSLLDSTIRLQGRNNRTWVAELVLANCPLSSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSCTLPEMPPYLSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSSQDARRRSVNEDDNPPSPVGVDVMDSLMNQFQGQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWAASIPTILSHNALHVLLLPSPTPCMVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEATLSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPSRQGECTIFASVQELMASLSLPPSTRQ
Length1394
PositionTail
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.06
Grand average of hydropathy-0.178
Instability index49.61
Isoelectric point8.62
Molecular weight154787.39
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22398
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     289.68|      68|     370|     853|     931|       1
---------------------------------------------------------------------------
  400-  462 (87.86/36.53)	LQELKAILKTSNPSDNSfieTALPTlvVPILEPCGRS....ECLHIFVDLHSGM...FQPM....LYGLDQSML
  480-  537 (89.08/39.30)	LQQLKFWLGEQRCRQSV...KHLPT..VCS.DIVHLSNSATHPVGSLSKHKLFIKLTRLPQYYI..........
  853-  921 (112.74/68.37)	LQLLQVLYDTQAPLNAI...NKLPT..VPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIdIYCRSRGVV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     213.41|      32|      37|    1020|    1051|       2
---------------------------------------------------------------------------
  972- 1010 (27.47/ 7.74)	.........PSPvgvdvmdSLM.N...QFQG....QQQPQTMrggaggVYP...PLTSP
 1011- 1049 (60.66/25.96)	PPnylanvtPSP.......SMMPT...QSPGPLD.PSSPYTM......VSP...SHRGQ
 1050- 1083 (39.70/14.45)	WPgspqvsgPSP......gARIPG...MSPG..N.PS....L......HSP...IPDPN
 1084- 1120 (30.32/ 9.30)	SP....ragSSS.......QVMPT...SMPPPRKlPQRPWAA......SIPtilSHN..
 1121- 1149 (25.87/ 6.86)	.A.lhvlllPSP.......T..PC...MVPG.LA.GS..Y.L......CSP...LER..
 1178- 1213 (29.39/ 8.79)	.........PGV.......IMFKTdvlKCRVALN.PKNYQTL...qlkVTP...ENAGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.34|      16|      20|     703|     719|       3
---------------------------------------------------------------------------
  703-  719 (23.64/18.77)	NNRTWVAE....LVLANcPLS
  722-  741 (21.70/10.90)	NSKEQASTrhvyLTYEN.PLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     273.00|      90|     454|     149|     256|       7
---------------------------------------------------------------------------
  149-  256 (131.22/138.96)	TTGSYPRlPTCIRdKII....PPDPiTKTEKQTTLNQLNQILRHRLVTTD.......LPPQLANLTVANgrvkfrvEGefeatLTVMGDDPDIPWRLLKLEilvEDKETGD..GRALVHSL
  590-  692 (141.78/99.12)	TTGREAR.PGTKR.KIAgdqgDSEP.KKPKRSGEMCAFNKELAHLVAMCDtnmpfigLRAELSNMAIPN.......EG.....VQVEGDGSSHAIRLLKIP...PCRDVGEetRRALERSL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22398 with Med14 domain of Kingdom Metazoa
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