<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22393

Description Mediator complex subunit 6
SequenceMMPLLQELELLLLLIFAIFRPAAAVGGLNALMEPRGAANAAAAAAPVGDNLLGISWVDSGWVPILNPGNVLDYFSERSNPFYDRTCNNEIVKMQRLTLEHLNQMVGVEYILLHAQEPILYIIRKQQRQSPTQVIPLADYYIIAGVVYQAPDLGTVISSRVLSAVHGIQSAFDEAMSYCRYHPSKGYWWHFKDQEEREKTKPKSKKKEEPSSLFQRHRVDTLLLDLRSKFPPTFYQPKPGDKPIPVEVKKEPEPPAEAVKQEEREPATKSSAPAPPSKPPPEKRARLQ
Length287
PositionHead
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.08
Grand average of hydropathy-0.398
Instability index57.04
Isoelectric point8.37
Molecular weight32330.86
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22393
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.88|      13|      18|     244|     256|       1
---------------------------------------------------------------------------
  244-  256 (23.54/11.17)	PVEVKKEPEPPAE
  265-  277 (23.34/11.02)	PATKSSAPAPPSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.02|      11|      18|     120|     130|       2
---------------------------------------------------------------------------
  120-  130 (20.77/15.37)	YIIRKQQRQSP
  140-  150 (20.25/14.81)	YIIAGVVYQAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22393 with Med6 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FYQPKPGDKPIPVEVKKEPEPPAEAVKQEEREPATKSSAPAPPSKPPPEKRARLQ
233
287










Molecular Recognition Features






MoRF SequenceStartStop




1) PIPVEVKKEPEPPAEAVKQEEREPATKSSA
2) PSKPPPEKRARLQ
242
275
271
287