<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22391

Description "Transcription elongation factor A (SII), 3"
SequenceMTREEDLIRIAKKLDKMVSRNNTDGAIDLLKELKSFNMTLKLLQETRIGMSVNNIRKHCRDEEVIALAKVLIKEWKRLLDSGNSHSEKVDELKNGLDARKPAAATNSCSSEPQSSHRRLEAKPKHESDSDKNRNEKQNDNHINKKSHADDPGTDGKHLEGHQSEKYLQEIRAEKQTPAENPKPETDHKKQRHAPDLQSGKHKSDPIKHRSLEDLKKMRNAELLKKEKPPEEPKKYTDDGNQDKSRAEGRHEWPVGTPQRGKPAEAHKLIFERRGVLDSSVLYPTRFPSPPRPARPLLPIKRPSLDSKKDRKDGKESSSRHPHSQPASPPPKRPAAEIKKERKVPPDPNAPIAPLPFHLHPPPQRKEPPDPNAPLPPLPLHLHPPAAPPKRTSVDGGKDRESSRKPSSDSKPLPQKKPADCVKKDRKDSDDGKASKKLSEDTKRERKDSSDSKPPSTKKPTIEVKKEKHRKDSSELKPSQPAKGHSTDSKSVRRESLGSKPLGQPQRKPSTDSLDRKGKTEAPRTPTTPTSPLSPSFSSPGGPLSPHLATGDSVRDKCIEMLTAALRTDNDYKDFGANCDGMAAEIEDHIYQEIRATDMKYKNRVRSRISNLKDPKNPGLRRNVLAGSIELSRIASMSAEEMASDELKQLRNVLTQEAIREHQMAKTGGTTTDLLQCGKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKFC
Length714
PositionUnknown
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.03
Grand average of hydropathy-1.256
Instability index61.14
Isoelectric point9.59
Molecular weight80087.57
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
nucleic acid binding	GO:0003676	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22391
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.35|      22|      22|     341|     362|       1
---------------------------------------------------------------------------
  329-  360 (35.34/10.96)	PPkrpaaeikkeRKVPPDPNAPIAPLPFHLHP
  361-  383 (40.01/13.34)	PP.........qRKEPPDPNAPLPPLPLHLHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     575.08|      99|     154|     228|     326|       2
---------------------------------------------------------------------------
   73-  147 (105.39/34.24)	..KEWKRLLDSGN.....SHSEKVDELKNGLD.AR.KPAAATNSCS.................SE..PQSSHRRLEAK....PKH...ESDSDKNRNEKQ...NDNHINKKSH
  150-  227 (88.19/27.58)	DPGTDGKHLEGHQSEK..YLQEIRAEKQ..TPaENPKPETDHK...KQRHAPD...LQSGKHKSD..PIKHRSLEDLKKmrnAEL...LKKEK....................
  228-  326 (174.97/61.20)	PPEEPKKYTDDGNQDK..SRAEGRHEWPVGTP.QRGKPAEAHKLIFERRGVLDSSVLYPTRFPSP..PRPARPLLPIKR...PSL...DSKKDRKDGKES...SSRHPHSQPA
  384-  464 (105.90/34.44)	PAAPPKRTSVDGGKDResSRKPSSDSKPL..P.QK.KPADCVK...............KDRKDSD..DGKAS.....KK...LSE...DTKRERKDSSDSkppSTKKPTIEVK
  477-  556 (100.64/32.41)	PSQPAKGHSTDSKSVR..RESLGSK..PLGQP.QR.KPSTDS...LDRKGKTEAPRT.PTTPTSPlsPSFSSPGGPLS....PHLatgDSVRDK...................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.82|      14|      27|     671|     684|       4
---------------------------------------------------------------------------
  671-  684 (27.63/16.48)	TDLLQCGKC..KKKNC
  699-  714 (25.20/14.49)	TTFVLCNECgnRWKFC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22391 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNSHSEKVDELKNGLDARKPAAATNSCSSEPQSSHRRLEAKPKHESDSDKNRNEKQNDNHINKKSHADDPGTDGKHLEGHQSEKYLQEIRAEKQTPAENPKPETDHKKQRHAPDLQSGKHKSDPIKHRSLEDLKKMRNAELLKKEKPPEEPKKYTDDGNQDKSRAEGRHEWPVGTPQRGKPAEAHKLIFERRGVLDSSVLYPTRFPSPPRPARPLLPIKRPSLDSKKDRKDGKESSSRHPHSQPASPPPKRPAAEIKKERKVPPDPNAPIAPLPFHLHPPPQRKEPPDPNAPLPPLPLHLHPPAAPPKRTSVDGGKDRESSRKPSSDSKPLPQKKPADCVKKDRKDSDDGKASKKLSEDTKRERKDSSDSKPPSTKKPTIEVKKEKHRKDSSELKPSQPAKGHSTDSKSVRRESLGSKPLGQPQRKPSTDSLDRKGKTEAPRTPTTPTSPLSPSFSSPGGPLSPHLATGDSVRDKCIEMLT
82
562










Molecular Recognition Features






MoRF SequenceStartStop




1) AEAHKLIFERRGVLDSSVLYPTRFP
2) HRSLEDLKKMRNAELLKK
3) KRPAAEIKKERKVP
4) RPARPLLPIKR
263
208
331
291
287
225
344
301