<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22386

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMEVPGADSDWRSPQFRQKVVAQIEDAMRKAGSGNTTHKSGTDMENHVFIKAKTREEYLSLVARLIIHFRDIHKKALGGADPMNALTNLTGVGGGMGMGPRPPGTAVGGMGAMGQMQLGQHAMAGVQGNPQAMGTPGQMSVQQMVQQQQQQQSMQFQQFQQAQQQQQAQQNAALQQQQQQFQQQQQLRALQQHAQNQQLQQQQHAQNQQQQNQVCPQIDPAEPAAKPSPDAFRPHSIYLRAPSLTNGAAFQLLTHSNMVAPK
Length261
PositionTail
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.04
Grand average of hydropathy-0.801
Instability index55.72
Isoelectric point9.61
Molecular weight28685.92
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22386
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     177.00|      35|      35|     145|     179|       1
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  115-  142 (33.01/ 6.38)	........MQLGQHAMAgvQGNPQAMGTPG.QMSVQQ
  145-  179 (65.28/20.48)	QQQQQQQSMQFQQFQQA..QQQQQAQQNAALQQQQQQ
  181-  204 (42.85/10.68)	QQQ..Q...QLRALQQH..AQNQQ......LQQQQHA
  205-  230 (35.86/ 7.62)	QNQQQQNQV.CPQIDPA..EPAAKPSPDA........
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22386 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LGGADPMNALTNLTGVGGGMGMGPRPPGTAVGGMGAMGQMQLGQHAMAGVQGNPQAMGTPGQMSVQQMVQQ
2) QSMQFQQFQQAQQQQQAQQNAALQQQQQQFQQQQQLRALQQHAQNQQLQQQQHAQNQQQQNQVCPQIDPAEPAAKPSPDAFRPHSIYLRA
76
151
146
240










Molecular Recognition Features






MoRF SequenceStartStop




1) DAFRPHSIYLRA
229
240