<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22379

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAALLERLHAKHNASRPWEGTINVVRQAMEKRGVMNEAGHQLLLNCLETLQRALKVSSLPSMTDRLESIARQNMLGSHLSPTKTECYITSDMFYVEVQLDTGGQLVDVKVAHQGENPTSCSELIQHLSEKNFEAFSKHLKGLVDLYRLPGDNKLKTKMYIALQSLELDLTKMMTMFRLATNANTVETILHGSVGWLTPRSGGNLVSLQCYVSPYDIFEVETGSQLSLTDNNVPCSLGVSVSVTIEGTSTVYKLPIAPLITGSHPVDNKGTPSFSTVSNSNSVDLPACFFLKMNRPMPFSLSFIQKLGNATSIPVFETPPPLSLLYQLIVQSQLQLLEEGSAIPATLNNMHFYSILPDQHHCYFLNGDAPVQDGHSLQGAMVSKIPFRHPAQVPLLLDIIRHQAAYNTLIGSCVKRTSVKEDSAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMEVIDSRQVSCHLYKGPSDALICTDEFITKVVTRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVETMVKNNPPPSGSPPYKMVGGDGTNPMGLPGLTGSNTPTGGGPPGGPNFAGPITTLFGMPRAERQAQGECLTPGGVTSQQPLPQQQQVHSDDYSKVTQNPILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPASNTKSHPMLMNLLKDNPTQDFAALYSSSPLERQNSSSGSPRTDSMGGACPSGNTKGKKKRPRGPEKGGVLPGVGASGGLGMKPQPGSSMPQHLQHHSVSHEDDFHRKLLSMDVDASQNSIFDVNLAGDSLDAHHSITPTLSQCGTPPPGSGMAYSQSHVQSQQQQSGSVPPRIVRLPSSDSIGPDITEILQELPEQTGKGSGGSHGQPEDGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPNSDSSSTNFFPDASDFNPDLLTSGHGFSQTYFDDSSPSADGDMDLVKGFGGSSQQNTPSGTPQNPQHGQSTPEPSLKDPFDMGIVFGGNSGGGKPLLGQAPDLIDTHSGGSQSPLMMGLGGACSDFKTTEPKVKPGLIRPKDENGGNGGSGSGMGSSSAEGKQIKRSRTPSSEGKSKDKNPKRKKLDPDGKSPSHSSGGRPYTPPSGGSGSGGSISGGGSKSPGSSGRSQTPPGGATPPIPKITIQIPKGTITGGKTSSHSGYTSSSSATSSTGGLGGTSSSSKSHHSHSSSSGKIKSKEGSMTQSSSSKPGGSGGGGGQSQMKGSSQGMGVGKPGSSPITKHGLSGPGGAGGGMGSGSKIKPQGGKPPGSLMNPNIKPNISPSHSRSSSSGDKLSSPMKIQQSQVPGTPPSSKAKSPIGSGSGSSGGSKSSSGGSSQKPGGGGSSSSTSSSSTSSSGSMSFSGSQLQYGSGGSGGGGGGNGSEGNGGGSGGGAGQNNSNNPNAKGKSPSRNKKPSLTAVIDKLKSVGSGGVGEDGCEVGTPVGGPGLTSTPCGPGNVPSGPPNLGSSKHSSSSQSGDYKREKSDKDGKAKVMVTGGGSGDKKMMDPKTSGSGGTTLAKIIISKPDGGSPSIKAKVTLQKPGEGSGESMRQQISGLKASPLFSGSTPKHDRSSPSHSRSPGYTPLNQDSESESGSSSVAEKSHQNSPSSDDDQTVRPLPPQDYMSSIPLSSGEKHKKHKKEKKKLKDKERERDRDRERDREKEKKKSSMSMGSSSHSTKADSWSRSPISASDSSLSMLGSDRPSRSSPMYMRNEDDDLMDSALTGDF
Length1745
PositionMiddle
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.04
Grand average of hydropathy-0.636
Instability index53.92
Isoelectric point8.75
Molecular weight180561.36
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22379
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.61|      29|      33|    1330|    1362|       1
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 1330- 1362 (44.18/16.94)	SSKAKSpigSGSGSSGGSKSSSgGSSQKPGGGG
 1363- 1391 (36.43/ 6.02)	SSSSTS...SSSTSSSGSMSFS.GSQLQYGSGG
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1827.41|     329|     329|     542|     870|       2
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   36-  226 (145.79/25.73)	.................................................................................................................................NEAGHQLLLNCLE....TLQRALKV..S.SLP............smTDRLE.S..IA...RQN..MLG..ShLSPTKTecyiT....SDMFYVE.VQL.DTGGQL.VDVKVA.HQG....ENPT....SCSELIQHL................SEKNFEA..FSKHLKGL.VDLYRLP.GDNKL...KTKMY........I...ALQSLELDL.....TKM.MT...........MFRLATNANTVETILHGSvGWLT..PRsggnLVSLQC..YVSPyDIFEV......ETGS....Q....LS..............
  227-  537 (346.96/69.69)	..........LTD.NNVPCSLG..VSVSVT.I......EG.TSTVYKLPIAPLITGSHPVDNKGTPSFSTVSNSNSVDLPACFFLKMNrpmPFSLSFIQKLGNATSIPV.......FETPPPLSLLYQlIVQSQLQLLEEGSAIPaTLNNMHFY..S.ILP..............DQHHC.YflNGDAPVQDghSLQ..G.AMVS.............K..IPfRHP.AQVPLL.LDI.IRHQAA....YNTL....IGSC....VKRT.............SV.KEDS....AGLLQFEVCPLTDSSFSVSFqhpVNESLvcvvmeviD...SRQ.VSCHL.....YK..G...........PSDALICTDEFITKVVTRC.MSIPvtMR....AIR.RKAETIQA.D.TPAL.SL.IAQTVetmvK....NNPPPSGSP....PYK
  542-  870 (578.71/120.35)	DGTNPMGLPGLTG.SNTPTGGG..PPGGPN.F......AGPITTLFGMPRAERQAQGECLTPGGVTSQQPLPQQQQVHSDDYSKVTQN...PILTSLLQITGNVGSSPSSQNAPQPHQTPPPTSSPAS.NTKSHPMLMNLLKDNP.TQDFAALY..S.SSP..............LERQN.S..SSGSPRTD..SMG..G.ACPSGN....T....KGKKKRP.RGP.EKGGVL.PGVGASGGLG....MKPQ....PGSSMPQHLQHH.............SVSHEDD..FHRKLLSMDVDASQNSIFDVNL...AGDSL........D...AHHSITPTL.....SQC.GT..PP......PGSGMAYSQSHVQSQQQQS.GSVP..PR....IVRLPSSDSIGP.DITEILQEL.PEQTG....K....GSGGSHGQPEDGGPLG
  875- 1128 (280.99/55.28)	D...........S.SSSGQGSA..VFDSADiF.ntnsnENPFTDAADLI.AE..AAATAATP........................................NSDSS.STNFFPDASDFNPDLL......TSGH..............GFSQTYfdD.SSPsadgdmdlvkgfggSSQQN.T..PSGTPQNP..QHG..Q.STPEPS....L....K........DP.FDMGIV.FG.GNSGG.G.....KPL....LGQA.PDLIDTH.............S....G..............GSQSPLM.MGL...GGACS........DfktTEPKVKPGLirpkdENG.GN..GG......SGSGM..GSSSAEGKQIKR.S.............RTPSSEGKSK.DKNPKRKKLdPD..G....KspshSSGGRPYTPPSGGS.G
 1136- 1336 (213.07/40.43)	GGSKS...PGSSGrSQTPPGGA..TPPIPK.I...........TI.QIPKG.......TIT.GGKTSS.............HSGYTSS...SSATS...STGGLGGTSSSSKSHHSH......SSSSG.KIKSKEGSMT..............Q..S.SS...............SKPGG.S..GGGGGQSQ...MK..G.S.SQGM....G....VGKP..G.SSPiTKHGLSgPG.GAGGGMGsgskIKPQggkpPGSLMNPNIKPN............iSPS.......HSR........SSSS..........GDKL........S...SPMKIQQ.......SQVpGT..PPsskaksP....................................................................................
 1456- 1727 (261.89/51.10)	EVGTPVGGPGLTS...TPCGPGnvPSGPPN.LgsskhsSSSQSGDYKREKSDKDGKAKVMVTGGGSGDKKMM.......DPKTSGSGG...TTLAKII.ISKPDGGSPSIK.AKVTLQKPGEGSG......ESMRQQISGLKASP.......LF..SgSTP.............kHDRSSpS..HSRSPGYT..PLNqdS.ESESGS....SsvaeKSHQNSP.SSD.DDQTVR.PLPPQD...Y....MSSI....PLSSGEKHKKHKkekkklkdkererDRDRERDreKEKKKSSMSMGSSSHSTKADSW...SRSPI........S...ASDS...SL.....SML.GSdrPS......RSSPM................................................................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22379 with Med1 domain of Kingdom Metazoa
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