<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22372

Description "Transcription elongation factor A (SII), 2"
SequenceMAKTQEVERIAKKLDKMVHKKNTDGALDLLRELKNMKMSLETLQSTRVGMSVNAVRKQSSDEEVQTLAKTLIKSWKKLLDGAEGKPDEKKKEGSLVRSTSTSKDSGSTEKSSEKSVETPTVPHRFTSFPPAPVTTDNVRTKSRELLVAALQTGDDFKAAGVDCEHLAAQIEERIFQEFKSTDMKYKTRLRSRISNLKDQKNPELRRNVLCGSIAPERIASMTAEEMASAELKQIREALTKESIREHQLSKVGGTETDMFICSKCHGKNCTYTQVQTRSADEPMTTFVLCNGCGNRWKTFSIVSPHHPSFLLLLQFHRLVLLPPAYVSDLFPFPFCLLSLSTFPSILVLPFFSSPSSLPYLAAGSVSSSVEDVCICVCVCVCGCVYY
Length386
PositionUnknown
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.06
Grand average of hydropathy-0.306
Instability index49.55
Isoelectric point8.74
Molecular weight42951.04
Publications
PubMed=23542700

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
nucleic acid binding	GO:0003676	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
regulation of transcription, DNA-templated	GO:0006355	IEA:InterPro
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22372
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.12|      19|      27|     256|     274|       1
---------------------------------------------------------------------------
  256-  274 (37.61/28.26)	TDMFICSKCHGKNCTYTQV
  284-  302 (36.52/27.21)	TTFVLCNGCGNRWKTFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.92|      19|      27|     131|     157|       2
---------------------------------------------------------------------------
  131-  157 (24.25/35.93)	APVTTdnvrtksrELLVAALQTG..DDFK
  159-  179 (28.67/20.00)	AGVDC........EHLAAQIEERifQEFK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     134.63|      49|      54|      11|      64|       3
---------------------------------------------------------------------------
    5-   61 (58.42/54.47)	QEVeriAKKLDKmVHKKNTDGALDLLRElKNMKMSLetLQSTRVGMSVNAVRKqSSD
   62-  113 (76.21/47.93)	EEVqtlAKTLIK.SWKKLLDGAEGKPDE.KKKEGSL..VRSTSTSKDSGSTEK.SSE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22372 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GAEGKPDEKKKEGSLVRSTSTSKDSGSTEKSSEKSVETPTVPHRFTSFPPAPVTTDNVRTKSRE
81
144










Molecular Recognition Features






MoRF SequenceStartStop




1) LAKTLIKSWKKLL
67
79