<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22370

Description Mediator complex subunit 14
SequenceMAPVQIGSDGPLVPLGGPVVSGPQPPPPGTPATQGVKLSLLIEFLLQRTYHEITLLAELKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQAILFVDTADRLALLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKTEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYNCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEEKYVPAKYLTLSVWNQQVLGRKTGTASVHKVTIKIDESDGSKPLQISHEPALPACDSKLMERAMKIDHLSVEKLLIDSVHARAHQKLQELKAILKTSNPSDNSFIETALPTLVVPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKTVNDDMKRILSWLQQLKFWLGEQRCRQSVKHLPTVCSDIVHLSNSATHPVGSLSKHKLFIKLTRLPQYYIVVEMLEVPSSPTALQYKYSFLSVSQVEGEDGPMCAQLLQLFKPNLEHLVQDPTTGREARPGTKRKIAGDQGDSEPKKPKRSGEMCAFNKELAHLVAMCDTNMPFIGLRAELSNMAIPNEGVQVEGDGSSHAIRLLKIPPCRDVGEETRRALERSLLDSTIRLQGRNNRTWVAELVLANCPLSSTNSKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWKAISQLYQCVLNFSCTLPEMPPYLSQFSEVRLYNYRKLVLCYGTTKGSSVTIQWNSNTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVLQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLNMFVDSSQDARRRSVNEDDNPPSPVGVDVMDSLMNQFQGQQQPQTMRGGAGGVYPPLTSPPPNYLANVTPSPSMMPTQSPGPLDPSSPYTMVSPSHRGQWPGSPQVSGPSPGARIPGMSPGNPSLHSPIPDPNSPRAGSSSQVMPTSMPPPRKLPQRPWAASIPTILSHNALHVLLLPSPTPCMVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQELSIVNSNEPGVIMFKTDVLKCRVALNPKNYQTLQLKVTPENAGPWSQEELQVLERFFETRVAGPPFKFNTLSAFTKLLGAPTNVLRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKAKMLFFLQLTQRIPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALLVSNILKRFNELHPSRQGECTIFASVQELMASLSLPPSTRQ
Length1383
PositionTail
OrganismXiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Xiphophorus.
Aromaticity0.06
Grand average of hydropathy-0.168
Instability index49.78
Isoelectric point8.57
Molecular weight153487.89
Publications
PubMed=23542700

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22370
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     422.03|     136|     344|     839|    1027|       1
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  839-  990 (208.80/142.72)	KNPNVLQlLQVLYDTQAP.....LNAINKLPTVPMLGLTQRTNTaYQCFSILPQSPTHIrlaFRNmyCIDIYcrsrGVVAIRDGAYSLFDNTKIVEGFYPA......PG.....LKTFLNMFVDSSQdarRRSVNEDdnPPS...PVGVDVMDSLMNQFQGQQQPQTMRGG
 1028- 1053 ( 1.35/64.99)	.............................................................................................................................................S...PYTM.VSPSHRGQWPGSPQVSGPSPG
 1186- 1339 (211.87/105.88)	KNYQTLQ.LKVTPENAGPwsqeeLQVLERFFETRVAGPPFKFNT.LSAFTKLLGAPTNV...LRD..CVRIM....KLELFPDQAGQLKWNVQFCLTIPPSappiapPGtiavvLKAKMLFFLQLTQ...RIPVPQD..PVSiivPIVYDMATGLTQQADIPRQ.HSSSGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     419.95|     108|     454|     140|     247|       2
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  140-  247 (185.90/106.42)	TTGSYPRLPTCIRDKI....I....PPDPITKTEKQTTLNQLNQILRHRLVTTD.......LPPQ...LANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLK.....LEILVEDKETGD..GRALVHSL
  486-  579 (100.97/54.39)	...SVKHLPTVCSDIVhlsnS....ATHPVGSLSKHKLFIKL..........TR.......LPQYyivVEMLEVPSSPTALQYKYSFLSVSQVEGEDGPMCAQLLQlfkpnLEHLVQD...............
  581-  683 (133.08/74.06)	TTGREAR.PGTKR.KI....AgdqgDSEP.KKPKRSGEMCAFNKELAHLVAMCDtnmpfigLRAE...LSNMAIPN.......EG.....VQVEGDGSSHAIRLLK.....IP...PCRDVGEetRRALERSL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.20|      12|      20|     706|     723|       4
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  706-  723 (12.15/20.83)	NcPLSstnskEQASTRHV
  729-  740 (23.05/11.67)	N.PLS.....EPVGGRKV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     158.97|      50|     149|     273|     326|       5
---------------------------------------------------------------------------
  273-  326 (81.81/62.69)	CLHSFCLSLQLEvLHSQTL..MLI...RERWGDLvqeEKYVPAKYLTLSVWNQQV...LGRK
  424-  481 (77.16/47.93)	CGRSECLHIFVD.LHSGMFqpMLYgldQSMLDDI...EKTVNDDMKRILSWLQQLkfwLGEQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.46|      16|      20|     782|     797|       6
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  782-  797 (28.80/15.66)	NYRKLVLCYGTTKGSS
  805-  820 (28.66/15.55)	NTQRFHLALGTVGPNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.23|      17|      90|     997|    1018|       8
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 1001- 1018 (31.64/21.11)	PPPNYLANvTPSPSMMPT
 1090- 1106 (34.60/10.91)	PPPRKLPQ.RPWAASIPT
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22370 with Med14 domain of Kingdom Metazoa
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