<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22361

Description Mediator complex subunit 23
SequenceMALSMEAQLQSIFEDVVKTVMIEEAFAGMFMDTPEDERTKLISCLGAFRQYWGTLPLESHEQCVQWIVRFIHSQHSPKRISFLYECLAMAVETSLLPPRMVCAALISSDSLEWERTQLWALTFKLIRKIIGGVDYKGVRDLLKALLDKIQTIPTTVSSSIVQQLLAAREVVEYILDRNACLLPAYFAVTEIRKLYPEGQLSHWLLGSLISDFVDSFRPTARINSICGRCSLLPVVNNSGAICNSWKLDPSTLHFPLKGMLPFDKVTFFDFKLIKDTCMGKHSDEFISLSHQELFEPQTGLLRYVLEQPYSREMVCNMLGLNKQQKQRCPVLEEQLVDLVVYAMERSESEEHFDADVGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLNKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKECIPVPDINKPQSTHSFAMTCIWIHLNRKAQNDNSKLQIPIPHSLKLHHEFLQQSLRNKSLGMSDYKIALLCNAYSTNSECFPLPMGALVETIYGNGTMRINLPGTNCMASAAVTPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPNVFKCHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHSLAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFSRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIHGTWCKDILQTIMNFTPHNWASHTLSCFPAPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQGSPPLFLCLLWKMLLETDHINQIGFRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHENNEAQVCYFIIQLLLLKPNDFRNRVNDFVKENAPEHWLQSDWHNKHMNYHKKYPEKLYFEGLAEQVNPPMQLQPQYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGSLYKFHDRPVTYLYNTLHYYERQLRDRTNLKRKLVHAIMSSLKDNRSPGWCLSETYLKFGINPREDNVWIPDDTYYCKLIGRLVDTMAGKSPGPFPNCDWRFNEFPNPAAHALHVTCVELMALAVPGKDVGNALLNVVLKSQPLVPRENITAWMNAIGLVITALPEPYWIVLHDRIVSVISSPALTSETEWAGYPFALLDFTACHQSYSEMNCSYVLALAHAVWHHSSIGQLSLIPKFLSETLKPIVQTEFQLLYVYHLVGPFLQRFQQERTRCMLEIGVAFYEMLQAVDQHCQHLSFMDPICDFLYHIKYMYTGDSVKEQVEKIIMTLRPAMKLRLRFITHSSIVETSSSAAAATSSSSATSSTPQPPSSSLSTSAAASPSSSQHAHTAM
Length1416
PositionTail
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.10
Grand average of hydropathy-0.019
Instability index44.92
Isoelectric point6.89
Molecular weight161329.18
Publications
PubMed=21551351

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22361
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      30|     372|     381|       1
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  372-  381 (18.69/10.89)	IFFVLFQFAS
  405-  414 (19.45/11.66)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     197.98|      41|     843|     178|     218|       2
---------------------------------------------------------------------------
  178-  218 (73.15/41.80)	NACL..LPA..Y.FAVTEIRKLYP.....EGQLSHWLLGSLISDFVDSFRP
  964-  986 (27.38/11.24)	....................KLYF.....EG.LAEQVNPPM..QLQPQYLP
  991- 1034 (46.82/24.22)	NVCLrfLPV..FdIVIHRFLELLPvskslETLLDH..LGSLYK.FHD..RP
 1035- 1073 (50.63/26.76)	VTYL..YNTlhY.YE....RQLRD.....RTNLKRKLVHAIMSSLKDNRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.05|      26|     797|     485|     533|       3
---------------------------------------------------------------------------
  503-  528 (47.34/55.61)	SDYKIALLCNAYSTNSECFPLPMGAL
  536-  561 (46.71/13.36)	GTMRINLPGTNCMASAAVTPLPMNLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.13|      36|     883|      40|      85|       4
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   40-   85 (58.88/55.23)	KLISCLGafrqywgtlpLESHE....QCVQWIVR..FIHSQHSPKRIS.FLYE
  897-  939 (50.25/28.06)	RLILCLA..........MRSHEnneaQVCYFIIQllLLKPNDFRNRVNdFVKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.42|      13|      36|     300|     312|       6
---------------------------------------------------------------------------
  300-  312 (22.87/15.59)	LLRYVLEQPYSRE
  338-  350 (21.55/14.24)	LVVYAMERSESEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     234.66|      71|     359|     744|     852|       9
---------------------------------------------------------------------------
  631-  705 (114.65/57.57)	W..GILHTLLEmfsYRMHHIQPH....YRVQLLSHLHSlAAVPQTNQNQLHLCVESTALRLITALGSSEVQPQFSRFLSDP
  744-  820 (120.01/128.54)	WckDILQTIMN...FTPHNWASHtlscFPAPLQAFFKQ.NNVPQESRFNLKKNVEEEYRKWKSMANENDIITHFSMQGSPP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.18|      13|      18|    1150|    1163|      15
---------------------------------------------------------------------------
 1150- 1163 (16.97/14.56)	VPGKDVgNALLNVV
 1170- 1182 (24.20/15.11)	VPRENI.TAWMNAI
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22361 with Med23 domain of Kingdom Metazoa
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