<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22360

Description Mediator complex subunit 14
SequenceMAPVQIGTDGQLVPLGGPVLSGPQPPPTGGGATQGVRLSLLIEFLLQRTYHEITLLAELLPRKTDMERKIEIVQFASRTRQLFVRLLALVKWASNAGKVEKCAMISSFLDQQTILFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKSEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLDILVEDKETGDGRALVHSLQVNFIHELVQARLCADEKPLQDMYTCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQEERYVPAKYLTLSVWNQQVLGRKTGTASVYKVTIKIDESDGSKPLQISHEPPLPSCDSKLIERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKANNPSDNAFIETALPTLIIPILEPCGRSECLHIFVDLHSGMFQPMLYGLDQSMLDDIEKSINDNMKRIISWLQQLKFWLGEQRCRQSVKHLPTVCTNVLHLSNSASHPVDSLSKHKLFVKLTRLPQYYIAVEMFEMPNSPTALQYKYSFLSVSQLEGEDGPLCAQLLQPFKPNLEQLAQDTIKGKGARPGTKRKAASAKISGEHGDPEPKKPKRSGEMCAFNKELAHVVAMCDTNMPFIGLRVELANMEIPNQGVQVEGDGSSHAICLLKIPPCKSVGEETRRALERSLLDCTFRLQGRNNRTWVAELVLANCPLNSTHSKEQASTRHIYLTYENPLSEPVGGRKVVEMFLNDWTAISQLYQCVLNFSRTLPDMPSYLSLFSEVRLYNYRKLVLCYGATKGSSVTIQWNSSSQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKNPNVMQLLQVLYDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSATHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLTMFVDSNQDARRRSVNEDDNPPSPVGVDVADTLMNQLQAQQQPQPMRATAGGVYPPLTSPPPNYHANVAPSPSMMPTQSPGNIHTSGSPSGVLRAPSPFGPTPSPSSLGIAMGQTSFASPHGTGMDPSSPYAMVSPSHRGQWPGSPQFSGPSPGARIHSMSPGNPSLHSPIPDPHSPRAGTSSQIMPTSMPPPRKLPQRPWAASIPTILTHNALHVLLLPSPTPCLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQEANLSIVNSNEPGVIMFKTDMLKCRVALNPKNYQTLQLKVTPENTGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPDQAGQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKSKMLFFLQLTQRLPVPQDPVSIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSNILKRFNELHPARQGECTIFASVHELMANLTLPPCTRQ
Length1441
PositionTail
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.06
Grand average of hydropathy-0.187
Instability index50.81
Isoelectric point8.78
Molecular weight159669.81
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
blood vessel morphogenesis	GO:0048514	IEA:Ensembl
embryonic viscerocranium morphogenesis	GO:0048703	IEA:Ensembl
neural crest cell differentiation	GO:0014033	IEA:Ensembl
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro
stem cell population maintenance	GO:0019827	IEA:Ensembl
ventricular system development	GO:0021591	IEA:Ensembl









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22360
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     118.53|      30|      30|    1025|    1054|       1
---------------------------------------------------------------------------
 1007- 1042 (49.59/20.08)	GVYPPLTSP.PPnYhanvaPSP.S....MMPTQSPGN..IHTSG
 1043- 1079 (43.57/16.71)	SPSGVLRAP.SP.F..gptPSP.SslgiAMGQTSFAS..PHGTG
 1090- 1123 (25.38/ 6.54)	SPSHRGQWPgSPqF...sgPSPgA....RIHSMSPGNpsLH...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.71|      35|     513|     858|     894|       2
---------------------------------------------------------------------------
  858-  894 (58.14/45.31)	MQLLQVLYDTQAPLNAInkLPTV.PM.LGLTQRTNTAYQ
 1355- 1391 (54.58/35.69)	LQLTQRLPVPQDPVSII..VPIVyDMaTGLTQQADIPRQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     228.32|      63|     513|     136|     206|       3
---------------------------------------------------------------------------
  136-  198 (107.54/63.76)	LPSFAIPFAIDVLTT.GSY....PRLP.TCIR.DKIIPPDPITKSEK....QTTLNQLNQILRHRLVTTDLPPQ
  221-  277 (54.72/39.91)	............LTVmGDD....PDIPwRLLK.LDILVEDKETGDGRalvhSLQVNFIHELVQARLCADEKPLQ
  283-  338 (66.06/34.06)	LHSFCLSLQLEVLHS.QTLmlirERWG.DLVQeERYVPAKYLTLS........VWNQ..QVLGRKTGT......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.26|      17|      20|     534|     552|       4
---------------------------------------------------------------------------
  536-  552 (29.94/24.76)	YIAVEMFEMPNSPTALQ
  557-  573 (29.32/15.14)	FLSVSQLEGEDGPLCAQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.29|      16|      20|    1126|    1143|       5
---------------------------------------------------------------------------
 1132- 1150 (18.47/16.67)	PRAGTSSQImPT..........sMPPPrK
 1152- 1178 (23.82/10.61)	PQRPWAASI.PTilthnalhvllLPSP.T
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     213.13|      70|     511|     734|     817|       6
---------------------------------------------------------------------------
  737-  817 (96.59/101.07)	IYLTYEN..PLSEPvgGRKVVEMFLNDWTAISQLYQCVLN.FSRTLpDMPSYLsLFSEVRLYnyrKLVLcYGATKGSsvtIQWN
 1251- 1323 (116.54/70.89)	LKVTPENtgPWSQE..ELQVLEKFFETRVAGPPFKYNTLNaFTKLL.GAPTNI.LRDCVRIM...KLEL.FPDQAGQ...LKWN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.65|      23|     126|     450|     475|       9
---------------------------------------------------------------------------
  450-  475 (37.81/35.98)	FQPMLYGLDQsmlDDIE.KSINDNMKR
  578-  601 (36.83/25.36)	FKPNLEQLAQ...DTIKgKGARPGTKR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22360 with Med14 domain of Kingdom Metazoa
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