<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22358

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMDKRGPTNAASHQLMHSCLENLQRAMKVSSLSAMTDRLESIARQNMLGSHLSPSGTECYITSDMFYVEVQLDNGGQLVDVKVAHQGENPTSCLELIQHLREKNFDEFSKHLKGLVELYKLPGDNKLKTKMYIALQSLELDLTKMMHMYRLATSANTLETLLHGSVGLLSARSGGHLVSLHCYLSPYDLLEERTCAPLNLTDNNVPRSLGVSVSVTIEGTSAVYKLPIAPLITGSHPVDNKGTPSFSTVTNSNCVDLPACFFLKLNRPMPFSVAFIQRMGNATSIPVFESPPTLSPLYQLIVQSELRLQEDGSVTPPCPHNMTFYSVLPGQLHCYFLNGDAPVQDGQSLQGAIVSKIPFRHPAQVPLLLDIVRHQAAYNSLISSCVKRTSVDEDGAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMDVIDSRQVSCKLYKGPSDALICTDDFITKVVHRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVEIMVKNNLPPSGSPTYNMASCDGPNPMGLPGLTGGNTPTGGGPPGGPNFAGPITSLFGISRMERQAQGGECPSQPGGTGQQQLQQHQQQQAGQGHSEDYNKVTQNPILTSLLQITGSVGSSPNSQNAPTPHQTPPPTSSPASNTKNHPMLMNLLKDNPAQDFAALYGSSPLERQNSSSGSPRTEGMAGTCPGGSQKVKKKRPRVVEKGSMLPGASASGGSGLSMKSQQSSSMSQQHQHHPVSHEDDFHRELLSMDVDASQNSIFDVNLTGDGLDTPHSITPAPSQCGTPPAGPNMPYSQSHVQSQQQQPQGAAPSHMVRLSSSDSIGPDITEILSDLPEQTGKGSSGSHGQHPIGSSGEEGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPTSDSSSNHFFPDAADFNADLLTSGHGFSQNYFDDSSPSADGDMDLVKGFGGSSQQNTPSGTPQNPTSHGQSTPEPSLKDPFDMGIVFGGNSGGGKPLLGQASDMSDTHSGGSQSPLIMGAGCGDFKGAEPKVKQQQSHMRPKDENGGSSAGNAVVGMGSSSTECKQIKRSRTPSSEGKCKEKPPKRKKVDSDGKSPSHSSGGRPYTPPSGGSGSGGSMSGGGSKSPGSSGRSQTPPGGATPPIPKITIQITKGTITGGKTSSLSGYTSSSSATGGTGATGGNSGSKSHHSHSSSSSGKIKSKESSATPGSASKPGSAGITSGVPSQSKTPSQGIGIGKPGSSPINKHGLSGPGSSGSGIVGGNKTKPPGGKPPGSLMNPNIKPNISPSHSRSSSSGDKMSSPLKMQQAQVPGTPPSSKAKSPIGSGGSSSAGSKLSSGPGMSSQKPLGGGSSSGSTSSSSSSSSTSSSGSMTFSGSSQSQYGGGGSGGGGGSAAGGSGCGGGGSSGGSGGGTVAGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEVGPPVGGPGSGSVPSGGGPGNVPSGGALNICPSKHISTSQGGEYKREKSEKEAKAKVSVSGGNSGDKKLMDPKTGGVGTTGLAKIIISKPDGGSPSIKAKGPLQKSGEGSGDSIRPQMTSLKASPLFSGSTPKHDRSSPSHSRSPGCTPLNHDSESESGSSSVAEKSHQNSPSSDDDQTIRPLPPQDYLSSIPLSSGEKHKKHKKEKKKKERERERDRDRERDRDKEKKKSSMSMVPSSHPIKADSWSRSPISASDSSLSMLGPERPTRPSPLYMRNEDDDLMDSALTGNI
Length1754
PositionMiddle
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.03
Grand average of hydropathy-0.620
Instability index57.31
Isoelectric point8.59
Molecular weight180707.32
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22358
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|    1604.25|     272|     278|     962|    1238|       1
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  502-  635 (125.57/18.75)	....................................................................................................................PSGS......P.TYN......MASCDGP...NPMGLPGLTGGN.tpTGGGPPggpnFAGP..ItslfgiSRMERQAQGG.EC......PSQPG.GTG.......Q.QQLQQHQQQQAGQGHSED..YNKV.TQ.NPILTSLLQIT.......................GSVGSSPNS..QNA..PTPHqTPPP.................TSSPASN.....
  636-  881 (325.76/61.33)	.....TKNHPMLM.....NLLKDNPAQDFAAlYGSSplerQNSSSGSPRTEGMAGTCPGGSQKVKKKRP.....RVVEK.GSMLPG.ASASG.GSGL.SMKSQQSSSMSQQ...hQ......HH..P.VSH......EDDFHRELL....SMDVDASQN...SIFDVN....LTG...........DGLDTPHSITPA......P....SQCGT.PPAGPNMPYSQSHVQSQQQQPQGAA..PSHM.VRLSSSDSIGPDITEilSDLPEQTGK..GSS......GSHGQHPIG..SSGeeGGPL.GTPI....RDSSS....SGQGSAVFDSADIFNT
  887- 1139 (425.95/84.64)	PFTDAADLIAEAA..ATAATPT..SDSSSNH.FFPD....AADFNADLLTSGHGFSQNYFDDSS....................P...SADG.DMDLVKGFGGSSQ...QN....TPSGTP.QN..P.TSH......GQSTPEPSLKDPFDMGIVFGGN...SGGGKP....LLGQ..A......SDMSDTHSGGSQS......PLIMGAGCGDFKGAEPKVKQQQSHMRPKDENGGSSA..GNAV.VGMGSSSTECKQIKR..SRTPSSEGKCKEKPPKRkkvDSDGKSPSH..SSG..GRPY.TPPS....GGSGSGGSMSGGGSKSPGSSGRSQT
 1140- 1403 (340.82/66.27)	PPGGATPPIPKITiqITKGTITGGKTSSLSG.YTSS....SSATGGTGATGGNSGSKSHHSHSSSSSGK.....IKSKE.SSATPGSASKPG.SAGITSGVPSQSKTPSQG....IGIGKPgSS..PiNKH......GLSGPGSS..GS...GIV.GGNktkPPGGKP.pgsLMNPniK......PNISPSHSRSSSSgdkmssPLKMQQ..AQVPGTPPSSKAK.S...PIGSGGSSSA..GSKLsSGPGMSSQ..K.........PLGGGSSSGSTS.....SSSSSSSTS..SSG..SMTF.SGSSqsqyGGGGSGG...GGGS.AAGGSG....
 1404- 1642 (291.87/54.15)	.CGG..................GG..S..SG....G....SG..GGTVAGQNNANNPNAKGKSPSRNKKpsltaVIDKL.KSVGGGGVGEDGcEVGPPVGGPGSGSVPSGGgpgnVPSGGA.LNicP.SKHistsqgGEYKREKSEKEAKAKVSVSGGN...SGDKK....................LMDPKTGGVGT......TGLAKIIISKPDGGSPSIKAK.GPLQKSGEGSGDSI..RPQM.TSLKAS..............PLFSG....STPKH.....DRSSPSHsrSPG..CTPL.NHDS...eSESGSSSVAEKSHQNSP.SSDDDQT
 1647- 1753 (94.28/12.03)	PPQDYLSSIP.........................................LSSGEK.HKKHKKEKKKK.....ERERErDRDRERDRDK.............EKKKSSMS...mVPSSHP.IK..A.DSW................................................................SRS......PISASDSSLSMLGPERPTRPSPLYMRNEDDDLMDSAltGN..............................................................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.16|      42|     120|      19|      64|       3
---------------------------------------------------------------------------
   19-   62 (65.43/38.47)	LE.NLQRAMKVSSLSAMTDRLESIARQN..ML....GSHLspSGTECYITS
  137-  185 (59.74/28.49)	LElDLTKMMHMYRLATSANTLETLLHGSvgLLsarsGGHL..VSLHCYLSP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22358 with Med1 domain of Kingdom Metazoa
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