<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22349

Description Mediator of RNA polymerase II transcription subunit 1
SequenceMAAGPGVALQCDSPARELSLSVHQGSNQIHGDRIKTEESAEEEKESRSAVLLEKLHAKYIASRPWQETFKLVRQAMDKRGPTNAASHQLMHSCLENLQRAMKVSSLSAMTDRLESIARQNMLGSHLSPSGTECYITSDMFYVEVQLDNGGQLVDVKVAHQGENPTSCLELIQHLREKNFDEFSKHLKGLVELYKLPGDNKLKTKMYIALQSLELDLTKMMHMYRLATSANTLETLLHGSVGLLSARSGGHLVSLHCYLSPYDLLEERTCAPLNLTDNNVPRSLGVSVSVTIEGTSAVYKLPIAPLITGSHPVDNKGTPSFSTVTNSNCVDLPACFFLKLNRPMPFSVAFIQRMGNATSIPVFESPPTLSPLYQLIVQSELRLQEDGSVTPPCPHNMTFYSVLPGQLHCYFLNGDAPVQDGQSLQGAIVSKIPFRHPAQVPLLLDIVRHQAAYNSLISSCVKRTSVDEDGAGLLQFEVCPLTDSSFSVSFQHPVNESLVCVVMDVIDSRQVSCKLYKGPSDALICTDDFITKVVHRCMSIPVTMRAIRRKAETIQADTPALSLIAQTVEIMVKNNLPPSGSPTYNMASCDGPNPMGLPGLTGGNTPTGGGPPGGPNFAGPITSLFGISRMERQAQGGECPSQPGGTGQQQLQQHQQQQAGQGHSEDYNKVTQNPILTSLLQITGSVGSSPNSQNAPTPHQTPPPTSSPASNTKNHPMLMNLLKDNPAQDFAALYGSSPLERQNSSSGSPRTEGMAGTCPGGSQKVKKKRPRVVEKGSMLPGASASGGSGLSMKSQQSSSMSQQHQHHPVSHEDDFHRELLSMDVDASQNSIFDVNLTGDGLDTPHSITPAPSQCGTPPAGPNMPYSQSHVQSQQQQPQGAAPSHMVRLSSSDSIGPDITEILSDLPEQTGKGSSGSHGQHPIGSSGEEGGPLGTPIRDSSSSGQGSAVFDSADIFNTNSNENPFTDAADLIAEAAATAATPTSDSSSNHFFPDAADFNADLLTSGHGFSQNYFDDSSPSADGDMDLVKGFGGSSQQNTPSGTPQNPTSHGQSTPEPSLKDPFDMGIVFGGNSGGGKPLLGQASDMSDTHSGGSQSPLIMGAGCGDFKGAEPKVKQQQSHMRPKDENGGSSAGNAVVGMGSSSTECKQIKRSRTPSSEGKCKEKPPKRKKVDSDGKSPSHSSGGRPYTPPSGGSGSGGSMSGGGSKSPGSSGRSQTPPGGATPPIPKITIQITKGTITGGKTSSLSGYTSSSSATGGTGATGGNSGSKSHHSHSSSSSGKIKSKESSATPGSASKPGSAGITSGVPSQSKTPSQGIGIGKPGSSPINKHGLSGPGSSGSGIVGGNKTKPPGGKPPGSLMNPNIKPNISPSHSRSSSSGDKMSSPLKMQQAQVPGTPPSSKAKSPIGSGGSSSAGSKLSSGPGMSSQKPLGGGSSSGSTSSSSSSSSTSSSGSMTFSGSSQSQYGGGGSGGGGGSAAGGSGCGGGGSSGGSGGGTVAGQNNANNPNAKGKSPSRNKKPSLTAVIDKLKSVGGGGVGEDGCEVGPPVGGPGSGSVPSGGGPGNVPSGGALNICPSKHISTSQGGEYKREKSEKEAKAKVSVSGGNSGDKKLMDPKTGGVGTTGLAKIIISKPDGGSPSIKAKGPLQKSGEGSGDSIRPQMTSLKASPLFSGSTPKHDRSSPSHSRSPGCTPLNHDSESESGSSSVAEKSHQNSPSSDDDQTIRPLPPQDYLSSIPLSSGEKHKKHKKEKKKKERERERDRDRERDRDKEKKKSSMSMVPSSHPIKADSWSRSPISASDSSLSMLGPERPTRPSPLYMRNEDDDLMDSALTGNI
Length1829
PositionMiddle
OrganismTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Eupercaria> Tetraodontiformes> Tetradontoidea> Tetraodontidae> Takifugu.
Aromaticity0.03
Grand average of hydropathy-0.620
Instability index57.51
Isoelectric point8.52
Molecular weight189004.55
Publications
PubMed=21551351

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22349
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|    1296.13|     145|     145|    1173|    1317|       1
---------------------------------------------------------------------------
  576-  683 (117.90/21.34)	.....................................PPS..............................GSPTYNmASCDGPNPMGlPGLTG.GNT....PTGG.GPPGG.PNFAGPITSlfG.ISRMERQA........QGG..ECPSQP..GGT......G.......QQQLQ..QHQQQQAGQ......GHSED...................................YN..KV.T.......QNPILT.SLLQItG
  686-  862 (146.60/28.41)	GS.......SP..NS....QNA...PTPHqT......PPPtsspasntknhpmlmnllkdnpaqdfaalyGSSPLE.RQNSSSG..S.PRTEGMAGT....CPGG.SQKVK.KKRPRVVEK..GSMLPG..AS........ASG...GSGLS..MKS......QQSSSMSQQHQHHpvSHEDDFHRE......LLSMD.VDASQN.SIfdvnlTG.....D..G..LDT...PHSitPAPS.......QCGTPP.AGPNM..
  878- 1010 (113.29/20.20)	GA.......AP..SHmvrlSSSdsiGPDI.TeilsdlPEQ..............................TGKGSS.GSH...GQHP.IGSSGEEGG....PLG....TPI.....RD............................SSSSGQ..GSA...vfdSADIFNTNS.NEN..PFTDAADLI......AEAAA.TAATPT.SD.....SSsnhffP..D..AAD...FNA..DLLT.......SGHGFS.QN.....
 1016- 1157 (148.45/28.86)	.........SP..S.....ADG...DMDL.V......KGF..............................GGSSQQ.NTPSGT.PQN.PTSHGQS.T....PEPS.LKDPF..DMGI.VFG..GNSGGGK..P........LLGQASDMSDThsGGSqsplimGAGCGDF..K.........GAEPK......VKQQQ.SHMRPK.DE.....NG.....G..S..SAGnavVGM..GSSSteckqikRSRTPS.SE....G
 1173- 1317 (262.89/57.03)	GK.......SP..SH....SSG...GRPY.T......PPS..............................GGSGSG.GSMSGGGSKS.PGSSGRSQT....PPGG.ATPPI.PKITIQITK..GTITGGKTSS........LSGYTSSSSAT..GGT......GATGGNSGSKSHH..SHSSSSSGK......IKSKE.SSATPG.SA.....SK.....P..G..SAG...ITS..GVPS.......QSKTPS.QGIGI.G
 1320- 1452 (141.57/27.17)	GS.......SPinKH....GLS...G............P...............................GSSGS..GIVGGNKTKP.PG..GK.......PPGSlMNPNIkPNISPSHSR..SSSSGDKMSSplkmqqaqVPGTPPSSKA.....................KSPI..GSGGSSSA........GSKL.SSG.PGmSS.....QK.....PlgGgsSSG...STS..SSSS.......SSSTSS.SG.SM.T
 1453- 1533 (118.64/21.52)	FS.......GS..SQ....SQY...G............................................GG.GSG.G...GGGS.A.AGGSG.........CGG......................GG..S..........SG...GSG....GGT......VAGQNNA...........NNPNAK......GKS.......PS.RN.....KK.....P.......S...LTA..VI..........DKLKSvGGGGV.G
 1536- 1647 (143.20/27.57)	G..................CEV...G...........PPV..............................GGPGSG.SVPSGGG....PG.....NV....PSGG.ALNIC.PSKHI......STSQGGE...........YKREKSEKEAK..AKV......SVSGGNSGDKKLM..DPKTGGVGTtglakiI.............I.....SK.....P............DG..GSPS......iKAKGPL.QKSGE.G
 1667- 1781 (103.60/17.82)	GStpkhdrsSP..SH..srSPG...CTPL.N......HDS.............................eSESGSS.SVAEKSHQNS.P.SSDDDQTirplPPQD.YLSSI.P......................................................LSSGEK.HK..KHKKEKKKK......ERERErDRDRER.DR.....DK.....E..K..KKS...SMS..MVPS............S.HPIK...
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.90|      10|     120|     247|     283|       5
---------------------------------------------------------------------------
  253-  262 (19.43/11.31)	SLHCYLSPYD
  405-  414 (19.47/14.14)	QLHCYFLNGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22349 with Med1 domain of Kingdom Metazoa
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