<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22295

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCEWEKRPKSTHCPSIPLVCAWSCRNLVAFTTDLKNDDEEKDVSHMIHIIDTEHPWDVYSINSGHTEVISCLEWDQSGSRLLSADGDGKIKCWSMSDHLVNSWESYLSNSVDGDPIVALSWLHNGVKLALHVEMSSSNNFSEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGNLLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRRDKYPAVTHLKFLTRENSEQVLLCASNQTGSIVECWSLRKEGLPVNNIFQHRSPVVVEKQPTILKWRILTTTNDLERVSAIALPKLPISTSNTDTKFCPGLGLALAFHDGSIQILHRTSFHTMCVFYGSSSTSGPGQRPGDESAIKRQRTGGPTIHFKAIQFSWTSLALAGIDNHGKLHMLRVSPSMGQVLDMNTTIRHLLFLLEYCMVTGYDWWDVLLHVQPTMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISATLKSLLRPHVLNSPDKSPGDRLTEICAKNTDTDIDKVMINLNTQDFVLDGPHLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFMRDGASLGMLREMLVMIRIWGLLKTSCLPTFTATSDNQDSLQLLFRLLTKLWLCCREDVPPQDPDESLIDECCLLPSQLLVPSMDWLPVNDGVIVKLQGKHPLRLQFGKSSSLPGQGATTPLEVFTRSPSSQKMDNLRCIHMGVCPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRKIPQAFN
Length830
PositionTail
OrganismPeriophthalmus magnuspinnatus
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Gobiaria> Gobiiformes> Gobioidei> Gobiidae> Oxudercinae> Periophthalmus.
Aromaticity0.07
Grand average of hydropathy-0.074
Instability index46.94
Isoelectric point7.88
Molecular weight92313.70
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22295
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     361.97|     101|     409|     187|     329|       1
---------------------------------------------------------------------------
   77-  126 (60.84/16.37)	..........................................................LEWDQSGSRLLSADGD.GKI..KCWSM.S.......DHL.VNSWESYLSN.SVD...GDPIVaLSW
  222-  329 (162.12/112.60)	DGSSSSPVQFYKVVVSVVSekcRIDTELLPSlfLRCTTDplRRDK....YPAVTHLKFLTRENSEQVLLCASNQTGSIV.ECWSLRK.......EGLPVNNIFQHRSPVVVE...KQPTI.LKW
  637-  741 (139.01/63.82)	DGASLGMLREMLVMIRIWG...LLKTSCLPT..FTATSD..NQDSlqllFRLLTKLWLCCRED.....VPPQDPDESLIdECCLLPSqllvpsmDWLPVND......GVIVKlqgKHPLR.LQF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      33.12|       9|     349|     391|     400|       2
---------------------------------------------------------------------------
  391-  400 (14.64/13.14)	GSSStSGPGQ
  742-  750 (18.49/10.85)	GKSS.SLPGQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22295 with Med16 domain of Kingdom Metazoa
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