<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22280

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMELAYVCDWEKRPKSTHCPSIPLVSSWSCRNLVAFTTDLKNDDDDTKDVSHMIHIIDTEHPWDVFSINSGHSEVISCLEWDQSGSRLLSADGDGRIRCWSMSEHLVNSWESALSSSVDGDPIVALSWLHNGVKLALHVEMSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPGGALLTASESLCRLRGRVALADIAFTGGGNIVVAATDGSSSSPVQFYKVVVSVVSEKCRIDTELLPSLFLRCTTDPLRRDKYPAVTHLKFLTRENSEQVLLCASNQSGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILTTTGDLERVSAVALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGAAQRPGDDAAIKRPRTTGPALHFKALQFSWTSLALAGVDGHGKLHMLRVSPSMGQVLDMNTTLRHLLFLLEYCMVTGYDWWDVLLHVQPSMVHNLVEKLHEEYMRQNQALQQVLATRIVAVKASLCKLSTATAARACDFHAKLLLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKNTDTDIDKVMINLKTEEFVLDGPPLQSLQQLIQWVGDFVLYLLANLPNQGSAVRPGFGFMRDGASLGMLREMLVMIRIWGLLKPGCLPTFTAMSDNQDSMQLLFRLLTKLWLCSRDDGPPQEPDESLIDECCLLPSQLLVPSMDWLPVNDGIIVKLQGKLPLRLQFGKASSLQGVGVSAPLDVFTRSPGAQKMDNLRCIHMGVSPTEESKACTRCGCVTMLRSPNKTNAMKQWEQRWIKNCLCGGLWRRMPPTFT
Length831
PositionTail
OrganismPoecilia latipinna (sailfin molly)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Cyprinodontiformes> Poeciliidae> Poeciliinae> Poecilia.
Aromaticity0.07
Grand average of hydropathy-0.019
Instability index48.51
Isoelectric point7.93
Molecular weight91788.36
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22280
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     149.99|      48|     209|      78|     127|       2
---------------------------------------------------------------------------
   78-  127 (82.76/53.25)	LEWDQSGSRLLSA.DGDGRI.RCWSM.SEHL.VNSWESAlSSSVDGD..PIVaLSW
  277-  330 (67.23/35.95)	LTRENSEQVLLCAsNQSGSIvECWSLrKEGLpVNNIFQH.RSPVVGEkqPTI.LKW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.29|      27|      95|     429|     455|       3
---------------------------------------------------------------------------
  429-  455 (46.33/31.56)	TSLALAGVDGHGKLHMLRVSPSMGQVL
  528-  554 (42.96/28.70)	TATAARACDFHAKLLLIAISSTLKSLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.66|      23|      31|     631|     655|       8
---------------------------------------------------------------------------
  631-  655 (39.60/30.06)	PGFGFMRDG.ASLGMLREMLvmIRIW
  664-  687 (38.07/22.28)	PTFTAMSDNqDSMQLLFRLL..TKLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.60|      12|      16|     732|     744|       9
---------------------------------------------------------------------------
  732-  744 (17.71/13.50)	LQG...KLPLRLqFGK
  748-  762 (16.90/ 7.50)	LQGvgvSAPLDV.FTR
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22280 with Med16 domain of Kingdom Metazoa
Unable to open file!