<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22278

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDVAYVCEWEKRPKSNHCPSIPLVCAWSCRNLIAFTTDLKNEEDEKDLSHMIHIIDTEHPWDVYSINSGHTEIISCLEWDQSGSRLLSADGDGQIKCWGMTEHLVNSWECTMGSAVEGDPIVALSWLHNGVKLALHVEKSGSTNFGEKFSRVKFSPSLTLFGGKPMEGWLAVTVSGLVTVSLLKPSGALLTASESLCRLRGRVALADIAFTSGGNIVVAAADGSSSSPVQFFKVCVSVVNEKCRIDTELLPSLFMRLTIDAVRREKYPAVTHLKFLTRENSEQVLLCASSQMGSIVECWSLRKEGLPVNNIFQHRSPVVGEKQPTILKWRILSATNDLDRVSAIALPKLPISISNTDLKVASDTKFCPGLGLALAFHDGSIQILHRLSLHTMGVFYGPASCGPSQRVGEESAIKRQRGPGPAAHFKALQFSWTSLALVGIDNHGKLHMIRVSPSMGQMLDMNTLLRHLLFLLEYCMVTGYDWWDVLLHVQPGMVHNLVEKLHEEYMRQNQALQQVLSTRIVAVKASLCKLSSATAARACDFHAKLLLIAISSTLKSLLRPHLLNTPDKTPGDRLAEICAKNTDTDIDKVMINLKTEEFVLDASTLQSLQQLIQWVGDFVLYLLANLPNQGSMVRPGFGFLRDGPSLGLLREMMVVIRIWGLLKPGCLPIYTATSDNQDSMFLLFRLLTKLWLCVRDEGHPQEPDEPLIDECCLLPSQLLVPTLDWLPINDGIICKLQGKHPLRLQFGKPHSLPGLGPGPPSQVEVFSRTPGSQRMDHLRCLHMGVCPTEDSKACTRCGCVTMLHSPNKTTAVKQWEQRWMKNCLCGGLWRRVHSSMS
Length837
PositionTail
OrganismParamormyrops kingsleyae
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Osteoglossocephala> Osteoglossomorpha> Osteoglossiformes> Mormyridae> Paramormyrops.
Aromaticity0.07
Grand average of hydropathy-0.016
Instability index43.05
Isoelectric point7.71
Molecular weight92824.84
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22278
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.08|      42|     114|     216|     257|       1
---------------------------------------------------------------------------
  216-  257 (71.24/49.41)	IVVAAADGSSSSPVQFFKVCVSVVNEKCRI..DTELLPSLFMRL
  331-  374 (64.85/44.28)	ILSATNDLDRVSAIALPKLPISISNTDLKVasDTKFCPGLGLAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.66|      31|     335|     418|     453|       2
---------------------------------------------------------------------------
  418-  448 (56.91/25.72)	GPGPAAHFKALQFSWTSLALVGIDNHGKLHM
  756-  783 (52.57/22.96)	GPGPPSQVEV..FSRTPGSQ.RMDHLRCLHM
  805-  826 (32.17/10.01)	SPNKTTAVKQWEQRWMKNCLCG.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     114.47|      33|      45|      61|      93|       3
---------------------------------------------------------------------------
   61-   93 (59.61/32.95)	WDVYSINSGHTEIISCLEWDQSGSRL.LSADGDG
  108-  141 (54.86/29.80)	WECTMGSAVEGDPIVALSWLHNGVKLaLHVEKSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      95.03|      31|     181|     449|     492|       4
---------------------------------------------------------------------------
  449-  492 (41.42/40.89)	IRvsPSMGQMLDMNT..LLRHLLFLLEYcmvtgydwWDVLlhvQPG
  633-  665 (53.61/23.23)	VR..PGFGFLRDGPSlgLLREMMVVIRI........WGLL...KPG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.68|      15|     514|     169|     199|       6
---------------------------------------------------------------------------
  170-  185 (19.96/13.15)	LAVTVSGLVTvSLLKP
  546-  560 (23.73/10.48)	LLIAISSTLK.SLLRP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22278 with Med16 domain of Kingdom Metazoa
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