<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22272

Description Mediator of RNA polymerase II transcription subunit 13-like (Fragment)
SequenceKWRRYNFGGHGDCGPIISAPAQDDPILLSFIRCLQANLLCVWRRDVKPDCKELWIFWWGDEPNLVGVIHHELQVVEEGLWENGLSYECRTLLFKAIHNLLERCLMDKNFVRIGKWFVRPYEKDEKPVNKSEHLSCAFTFFLHGESNVCTSVEIAQHQPIYLINEEHIHMAQSSPAPFQVLVSPYGLNGTLTGQAYKMSDPATRKLIEEWQYFYPMVLKKKEESKEEDELGYDDDFPVAVEVIVGGVRMVYPSAFVLISQNDIPVPQSVASAGGHIAVGQQGLGSVKDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLHNHMVHRVWKECILNRTQSKSQMSTPTLEEEPASNPATWDFVDPTQRVSCSCSRHKLLKRCAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHK
Length437
PositionMiddle
OrganismHomo sapiens (Human)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Hominidae> Homo.
Aromaticity0.08
Grand average of hydropathy-0.370
Instability index65.95
Isoelectric point6.52
Molecular weight48646.98
Publications
PubMed=16541075
PubMed=18691976
PubMed=19369195

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22272
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     125.11|      37|      61|     224|     260|       1
---------------------------------------------------------------------------
  224-  260 (63.07/38.23)	KEEDELGYDDDFPVAVE.VIVGGVRMVYPSAFVLISQN
  286-  323 (62.04/37.50)	KDPSNCGMPLTPPTSPEqAILGESGGMQSAASHLVSQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.31|      24|     130|       5|      28|       3
---------------------------------------------------------------------------
    5-   28 (47.10/32.95)	YNFGGHGDCGPIISAP.AQDDPILL
  137-  161 (41.21/27.88)	FTFFLHGESNVCTSVEiAQHQPIYL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.08|      14|      37|      42|      56|       4
---------------------------------------------------------------------------
   42-   56 (23.00/15.83)	WRRDVKPDCKELwIF
   80-   93 (27.08/13.06)	WENGLSYECRTL.LF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.79|      12|     298|      97|     108|       7
---------------------------------------------------------------------------
   97-  108 (23.47/13.12)	HNLLERCLMDKN
  397-  408 (23.32/13.00)	HKLLKRCAVGPN
---------------------------------------------------------------------------











Associated diseases
Disease
breast cancer	PMID:26452386



























Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22272 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) CAVGPNRPPTVSQPGFSAGPSSSSSLPPPASSKHK
2) KDPSNCGMPLTPPTSPEQAILGESGGMQSAASHLVSQDGGMITMHSPKRSGKIPPKLH
403
286
437
343










Molecular Recognition Features






MoRF SequenceStartStop




1) KWRRYNF
2) SRHKLLKRC
1
395
7
403