<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22254
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MNKGLCGRKHLPVHPSIPEAEESTQRRNCDVMKRSSLISGLQLKFAQRSWNDTLLLVQRCMEKSRIESKPCEPLVRSLERLQDVLHAPCRSVTRSRLEMIAQQQGMGFHVTEDTCYLTADLFYLEVLLPPCGGVQEVKVALHGEGPVPSESFLKTLRSEDFAAFSTRLKDLFTQYNIPGDNEIKLKLLESLQFLVRDLQKMTGEAEDCDPQQQLVNNNRTGCLVAGKEVMQTAQVTVGASAVPRRLQMASVLPEPLQLDSQGCPVGAPPSEVPGEMLPACFLLRLKPPVPVLSSFVEKLSLITDVAVAQTDQQWAPLHRLLMAGSQSAEETSDQLDLFTVKVLPDGETQRYVFPGASWDAPEQRATVVEAVSFTHPAQVPALLQLLRHQCAVNALLRSCWASQSAAPASPTGTPSDSQLFEVRPESSTSFSVTFTHPRTHSLAVLLVSVCGPQQITCRTFGAETSEAFLEDHMKNFLSIPATMKMLLSRLETASPPHPKSHPTSAEEDPPALMEVSQNAAVPEDSVSKTEVSPNPSVTSHLCSPVGTFAQQAEL |
Length | 554 |
Position | Middle |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae>
Oryzias.
|
Aromaticity | 0.05 |
Grand average of hydropathy | -0.198 |
Instability index | 61.29 |
Isoelectric point | 5.54 |
Molecular weight | 60673.68 |
Publications | PubMed=17554307
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
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Interaction
Repeat regions
Repeats |
>MDP22254
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.62| 11| 15| 70| 82| 1
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70- 82 (17.27/13.07) PCEPLVRSleRLQ
88- 98 (21.35/10.06) PCRSVTRS..RLE
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
4| 207.46| 47| 305| 124| 174| 2
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120- 165 (73.82/36.47) DLF......yLEVL..LPPCGGVQEVKVALHGEGPVPSESFLKTLRSEDFAAFS
170- 194 (23.14/11.57) DLFTQ.........ynIP...GDNEIKLKL.....LESLQFL............
395- 431 (52.02/25.10) .............L..LRSCWASQSAAPASPTGTPSDSQLF..EVRPESSTSFS
434- 480 (58.47/29.22) ..FTHprthsLAVL..LVSVCGPQQITC..RTFGAETSEAFLED.HMKNFLSIP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 52.91| 15| 16| 507| 521| 4
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507- 521 (26.65/15.73) EDPPALMEVSQNAAV
523- 537 (26.25/15.39) EDSVSKTEVSPNPSV
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