<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22249
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSGGPAVRISIESSCEKQVQEVALDGTETYVPPLSMSQNLAKLAQRIDFSQGSDSEEDGAEGESRDREWSKQEPEEEEGAVKFQPSLWPWDSVRNNLRSALTEMCVLHDVLSVVKEKKYMALDPVSHDPSAVKTPQVFQLISKKKSLGTAAQILLKGAERLSKSVAENQENRRQRDFNSELLRLRSQWKLRKVGDKILGDLSYRSAGSLFPHHGTFEVIKNTDIHLDKKIPEDYCPLDVQIPSDLEGSAYIKVSIQKQAPDIGDLGTVNLFRRLQKNKSGTQPWHVKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPGLQLSISLCHSTGDKKNSRSSPEKPKPDDHLYVLEHNLHQMMREFHKQQLSSVVMPHPATAPFGHKRMRLAGPLAYDKAEISSLQHNEGLLEKIIRQAKHIFLRSRTARTIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVKQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWHVLSFSNHVGLGPVESIGNASAITVASPNGEFAISVRNGPESGCKVLVQFPRSQSKELPKSDVIQDSKWSHLRGPHKEVHWSKMEGRNFVYKMELLMAALTPCP |
Length | 643 |
Position | Head |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi>
Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata>
Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae>
Oryzias.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.483 |
Instability index | 55.59 |
Isoelectric point | 8.67 |
Molecular weight | 72295.63 |
Publications | PubMed=17554307
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | core mediator complex GO:0070847 IBA:GO_Central
mediator complex GO:0016592 IBA:GO_Central
|
GO - Biological Function | transcription coregulator activity GO:0003712 IBA:GO_Central
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IBA:GO_Central
|
Interaction
Repeat regions
Repeats |
>MDP22249
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.48| 13| 17| 48| 60| 1
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48- 60 (23.12/12.55) DFSQGSDSEEDGA
68- 80 (24.36/13.59) EWSKQEPEEEEGA
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 264.89| 108| 252| 251| 388| 2
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187- 245 (64.13/27.27) QWKLRKVGDkiLGDLS.YR....SAGSLFPHHGTFEVIKntDIHLDKKIPEDYCPLDVQIPSDL..........................................................................................
256- 386 (154.99/160.63) QKQAPDIGD..LGTVNlFRrlqkNKSGTQPWHVKLEAAQ..NVLLCKEIFAQLSREAVQIKSQIphivVKNQIISQPFPG......LQLSIS.....LCHSTGdkknsR....SSPEKPKPDdhlYVL....EHNLHqmmrEFhkQQLSSVVMP
468- 539 (45.77/19.68) ....................................................................VKVLITSQGYEQicksiqLQLNIGvkqirVVHRDG.....RvitlSHQEQELQD...FLLsqmsQHQVH....AV..QQLAKVMGW
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 88.37| 24| 161| 442| 465| 3
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442- 465 (44.77/30.27) DSLASRIEDPQIQAHWSNI...NDVYE
605- 631 (43.60/29.29) DSKWSHLRGPHKEVHWSKMegrNFVYK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 45.52| 14| 16| 108| 122| 4
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108- 122 (19.71/20.21) HDVlSVVKEKKYMAL
127- 140 (25.81/20.41) HDP.SAVKTPQVFQL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 38.26| 11| 24| 544| 555| 5
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544- 555 (17.47/15.01) FSNHVGLGPvES
571- 581 (20.79/12.57) FAISVRNGP.ES
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