Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MANERLRVLEEVEKEIAMVLQCAGNIVLELSKDKQIANWKEVERQLLQFQSSTNRVESELSAQIRYLTQVPEPEPSVTSSFWPGTTEEQGERFPFSTKSHQSMKQRLVHVPHYEKQLYVSTDLH |
Length | 124 |
Position | Head |
Organism | Oryzias latipes (Japanese rice fish) (Japanese killifish) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.644 |
Instability index | 59.25 |
Isoelectric point | 5.58 |
Molecular weight | 14429.13 |
Publications | PubMed=17554307 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP22248 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.89| 22| 29| 10| 31| 1 --------------------------------------------------------------------------- 10- 31 (34.64/28.20) EEVEKEIAMVLQCAGNIVLELS 40- 61 (34.25/27.81) KEVERQLLQFQSSTNRVESELS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ANWKEVERQLLQFQ 2) SELSAQIRYLTQVPEPEPSVTSSFWPGTTEEQGERFPFSTKS | 37 58 | 50 99 |
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