<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22238

Description Mediator complex subunit 12
SequenceMMAAFGILSYEHRPLKRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSSDEHGSAKNVNFNPAKISSNFSSIIAEKLRFNSFPDTGKRKPQVNQKDNFWLVTARSQSSINSWFTDLGGTKPLTQLAKKVPIFSKKEEVFAYLAKYSVPVMRSAWMIKMTCAYHAAITETKVKKRHVIDPCIEWTQIITKYLWEQLQKVAEFYRQCPSQGCSSPPPATPADVETAMKQWEYNEKLAMFMFQDGMLDRHEFLTWVLECFEKVRPGEDELLRLLLPLLLQYSGEFVQSAYLSRRLAYFCTRRLNLLLSDRSLVPGTVGHPGHSILTQQGNALPSTPTSQPAGGNQPQTPFTDFYICQQHRPLVFGLSCMLQSIVLCCPSALVWHYSLTDSRNKTGSPLDLLPFAPSSLPMPGCNTAFTQQVRAKLREIEEQIKERGQAVEFRWSFDKCQETTAGFTIGRVLHTLEVLDNHSFEKSDFNNSLDSLYNRIFGSGQSKDGHEMSPDDDAVVTLLCEWAVCCKRSGRHRAMVVAKLLEKRQAEIEAERCAESEVVDEKGSVSSGSLSAATLPVFQDVLLQFLDTQAPTLTEPGNESERVEFSNLVLLFCELIRHDVFSHNIYMCTLISRGDLASESHLPRPRSPSDDESERKEQDAGSSVKMEDTGLSESMEIEHNSSANFDEMFSPPMHCESKGSPSPEKNAPDQDSKANCKDKSMDPAFPQLYDQPRHIQYATHFPIPQEESASHECNQRLVVLYGVGKLRDEARHTIKKITKDILKVLNRKSTAETGGEEGQKRKRSKPEAFPTAEDLFSKFQHLSHFDQHQVTSQVSRNVLEQINSFALGMSYHLPLVQHIQFIFDLMEYSLNISGLIDFAIQLLNELSLVEAELLLKSSSLVGSYTTSLCLCIVAVLRRYHTCLILNPEQTAQVFDGLQIVVKLVVNPADCSSAERCILAYLYDLYTSCSHLKNKFGEIISELCSKVKNSIYCNIDPSDSNMLWDPGFMLEAIANPSAHNFNHSVVGKILNDSPANRYSFVVNVLMDVCMDHRDPERVNDIGILCAELTAYCRSLSAEWLGILKALCCSSNNGNCGFNDLLCNVDVSDLSLHDSLATFVAILIARQCLLLEDLVRCVAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQRNPVPQDGAKSDKSMVGIRSSCDRHLLAASQNSIVVGAVFAVLKAVFMLGDAELRGSGLSHPAGLDDISDRRNVSIETASLDVYAKYVLKTICQQEWVGERCLKSLSEDSSALQDPVLGNIQAQRLLQLICYPHRQLDSDEGENPQLQRIKRILQNMDQWTMRQSCLELQLMIKQSSNNELYSLLENIAKATIEVFQKSAEMNSSNPSGNGTAAHGGSASNSNSTTSKIKPILSSSERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVQQIVTNWREDQYQDDCKAKQMMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLDIISSGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLRKELGDRQSESLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFEKEGLQVSTKQKISPWDVFEGLKHSAPLSWGWFGTTRVDRKTTKFEEQHRFLLYHTHMKPKPRSYYLEPLPLPPEEEEPLTPVSQEPEKKIMEPGKPEKNVPPVPAESKKKSSKKKKSAPPKTEVPGMNYVGVPDLMQNPQYVRTLYNQQQPMYPQNQPLPPGGPGLEPPYRPSRQPSKMMPPRPNYPGMMPGMQVNMPGIIGMEKQYPGNYKPQMARGEILRHHLQLRLQNPGMHGQQLRQMAPSQYPPMQASQGYTTYQSNMSMQQHPSQGAGIVPSSYGNPSFQGTHPGANPPVVDPLRQMPPRPSGYVHQQAPGYAHTMQNPPRFANQPLQPNHMIHNLSHMVSQGVHPGLRVADQQQQQQQQQQQQQTVQQQQQQRQQQQQQQYLRQQAMTQAQQQAIHQQQQQQQQQQQQVQRQQVPPQQQVQQPQQQQQQVSSGPPPGQAQNQGLGMQPLPPQQPLFQRQGMQQTQQQQQTAALVRQLQEQLSNTQPGQGTNSYY
Length2150
PositionKinase
OrganismOryzias latipes (Japanese rice fish) (Japanese killifish)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Neoteleostei> Acanthomorphata> Ovalentaria> Atherinomorphae> Beloniformes> Adrianichthyidae> Oryziinae> Oryzias.
Aromaticity0.07
Grand average of hydropathy-0.529
Instability index58.30
Isoelectric point6.95
Molecular weight241414.69
Publications
PubMed=17554307

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coactivator activity	GO:0003713	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22238
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     116.40|      15|      15|    2005|    2019|       1
---------------------------------------------------------------------------
 2005- 2019 (31.90/10.43)	VADQQQ.QQQQQQQQQ
 2022- 2036 (30.23/ 9.53)	VQQQQQ.QRQQQQQQQ
 2070- 2085 (29.58/ 9.19)	VPPQQQvQQPQQQQQQ
 2111- 2124 (24.69/ 6.57)	LF.QRQ.GMQQTQQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     324.82|      80|      81|    1724|    1804|       3
---------------------------------------------------------------------------
 1724- 1783 (84.76/34.53)	........................................EEEPLTP....................vSQEPEK.K.........IMEPG............KPEKNVPPVPAESKKKSSKKKKSAPPKTEVPGM...NYVGVPD
 1784- 1848 (111.48/44.05)	LMQ..NPQYVRTLYNQQQP.................MYPQ..................................nQ.........PLPPG............GPGLEPPYRP......SRQPSKMMPPRPNYPGMmpgMQVNMPG
 1849- 1948 (98.50/38.04)	IIG.mEKQYPGN.YKPQMArgeilrhhlqlrlqnpgMHGQQLRQMAP.....................SQYPPM.Q.........ASQ.GyttyqsnmsmqqHPSQGAGIVPSSYGNPSFQGTH........PGA...NPPVVDP
 2038- 2110 (30.08/ 6.36)	LRQqaMTQAQQQAIHQQQQ.................QQQQQQQQVQ.rqqvppqqqvqqpqqqqqqvsSGPPPG.QaqnqglgmqPLPPQ............QP.........................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     178.06|      57|     327|     244|     313|       4
---------------------------------------------------------------------------
  244-  307 (82.51/75.48)	FQDGMLdrhEFLTWVLECFEKvrPGEDELLRLLLPLLLQYSgEFVQSAYLSRRLaYFCT..RRLNL
  572-  630 (95.55/61.12)	FQDVLL...QFLDTQAPTLTE..PGNESERVEFSNLVLLFC.ELIRHDVFSHNI.YMCTliSRGDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.87|      27|     348|     988|    1017|       5
---------------------------------------------------------------------------
  988- 1017 (45.61/36.38)	IDPSDSNMLWDpgfMLEAIANPSAHNFNHS
 1337- 1363 (44.25/25.96)	IKQSSNNELYS...LLENIAKATIEVFQKS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.66|      14|      15|    1640|    1654|       6
---------------------------------------------------------------------------
 1640- 1654 (20.41/17.74)	TKgNKIAGFEK.EGLQ
 1657- 1671 (22.26/13.18)	TK.QKISPWDVfEGLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.21|      44|      81|     699|     742|       7
---------------------------------------------------------------------------
  699-  742 (81.92/49.13)	KNAPDQDSKANCKDKSMDP.AFPQLYDQPRHIQYATHFPIPQEES
  782-  826 (72.28/42.39)	KSTAETGGEEGQKRKRSKPeAFPTAEDLFSKFQHLSHFDQHQVTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     154.07|      50|     347|    1227|    1280|      10
---------------------------------------------------------------------------
 1089- 1144 (72.10/44.73)	GFNDL..LCNVDVSDLSLhDSLATFVAILIARQCLLLEdlvRCvaIPSLLNAACSEQD
 1228- 1279 (81.97/61.53)	GLDDIsdRRNVSIETASL.DVYAKYVLKTICQQEWVGE...RC..LKSLSEDSSALQD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.61|      31|     141|    1156|    1186|      13
---------------------------------------------------------------------------
 1156- 1186 (56.99/36.36)	LLHLFKTPQR........NPVPQDGAKSDKSM..VGIRSSC
 1290- 1330 (48.62/29.74)	LLQLICYPHRqldsdegeNPQLQRIKRILQNMdqWTMRQSC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.24|      21|      23|    1532|    1554|      20
---------------------------------------------------------------------------
 1532- 1554 (30.70/28.59)	QQTTewAVL.LLDIISSGTV..DMQS
 1557- 1580 (26.54/15.92)	ELFT..TVLdMLSVLINGTLaaDMSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.61|      20|    1316|      58|      77|      23
---------------------------------------------------------------------------
   58-   77 (36.12/24.59)	GSAKNVNFNPAKI.....SSNFSSI
 1381- 1405 (28.49/17.69)	GSASNSNSTTSKIkpilsSSERSGV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22238 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASESHLPRPRSPSDDESERKEQDAGSSVKMEDTGLSESMEIEHNSSANFDEMFSPPMHCESKGSPSPEKNAPDQDSKANCKDKSMDPAFPQLYDQPRHIQYATHFPIPQEESA
2) FQKSAEMNSSNPSGNGTAAHGGSASNSNSTTSKIK
3) KRPRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSSDEHGSA
4) MPGIIGMEKQYPGNYKPQMARGEILRHHLQLRLQNPGMHGQQLRQMAPSQYPPMQASQGYTTYQSNMSMQQHPSQGAGIVPSSYGNPSFQGTHPGANPPVVDPLRQMPPRPSGYVHQQAPGYAHTMQNPPRFANQPLQPNHMIHNLSHMVSQGVHPGLRVADQQQQQQQQQQQQQTVQQQQQQRQQQQQQQYLRQQAMTQAQQQAIHQQQQQQQQQQQQVQRQQVPPQQQVQQPQQQQQQVSSGPPPGQAQNQGLGMQPLPPQQPLFQRQGMQQTQ
5) NPQYVRTLYNQQQPMYPQNQPLPPGGPGLEPPYRPSRQPSKMMPPRPNYPGMMPGMQV
6) RSYYLEPLPLPPEEEEPLTPVSQEPEKKIMEPGKPEKNVPPVPAESKKKSSKKKKSAPPKTEVPGMNYVGVPD
631
1360
16
1846
1787
1711
743
1394
60
2121
1844
1783










Molecular Recognition Features






MoRF SequenceStartStop




NANANA