<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22221

Description "Transcription elongation factor A (SII), 3"
SequenceMTREEELIRIAKKLDKMVSRNNMEGALDLLRELKDFNMTLKLLQDTRIGMSVNGIRKHCTDEDVISLAKILIKNWKRLLESAHSQKDERPLELKNGSDDSKQTESSSGPSPDRESRRDAPVDFFPPPPPLHSHSAHPRRPSTEVKKERKETSETLPPTVSKHSHSHRSPPHHAPSIPPPPPPPPPKRPSLDLPKERKETADPDAPLPPLPLHLHPPAPPKRPLLDMKKDKGKEKEKERKDSTDFKQQPKKPTLEGKKERKDTTDSKSSQGQQSRDSKPQRRDSSNSKSSSSPPAKKLSVERRDSHSSKSAHPGLLQRKMSTDSNDGRKSKPETPKTPTTPTSPMSPSFSSGSGPLSPRLLTGDSIRDKCIEMLSAALRTDDDYKDYGANCDAMGAEIEDHIYQEIKATDMKYKNRVRSRISNLKDPKNPNLRKNVLDGAIDLRRIATMTAEEMASDELKQLRNVMTQEAIREHQMAKTGGTTTDLLQCGKCKKKNCTYNQVQTRSADEPMTTFVLCNECGNRWKVRTSCTKQKLN
Length535
PositionUnknown
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.02
Grand average of hydropathy-1.176
Instability index63.63
Isoelectric point9.54
Molecular weight60187.55
Publications
PubMed=25329095

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
nucleic acid binding	GO:0003676	IEA:InterPro
zinc ion binding	GO:0008270	IEA:InterPro

GO - Biological Process
transcription, DNA-templated	GO:0006351	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22221
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     231.11|      49|      49|     109|     157|       1
---------------------------------------------------------------------------
  109-  157 (96.18/31.58)	PSPD.RESRRDAPVDFFP..PPPPLH...........SHSAHP....RRPSTEVKKERKETSETLPP
  159-  205 (83.02/26.40)	VSKH.SHSHRSPP.HHAPsiPPPP..............PPPPP....KRPSLDLPKERKETADPDAP
  272-  334 (51.91/14.18)	QSRDsKPQRRDSSNSKSS..SSPPAKklsverrdshsSKSAHPgllqRKMSTDSNDGRKSKPET.P.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.80|      19|      27|     219|     245|       2
---------------------------------------------------------------------------
  219-  245 (26.63/25.79)	PKRPLLDmkkdkGKekeKERKDSTDFK
  248-  266 (37.17/16.63)	PKKPTLE.....GK...KERKDTTDSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.14|      39|     412|      20|      58|       3
---------------------------------------------------------------------------
   20-   58 (66.79/52.69)	RNNMEGALDLLR..ELKDFNMTLKLLQDTRIGMSVNGIRKH
  433-  473 (60.35/46.89)	KNVLDGAIDLRRiaTMTAEEMASDELKQLRNVMTQEAIREH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.84|      13|      16|     355|     367|       4
---------------------------------------------------------------------------
  355-  367 (23.09/11.60)	LSPRLLTGDSIRD
  373-  385 (22.75/11.35)	LSAALRTDDDYKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22221 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LLESAHSQKDERPLELKNGSDDSKQTESSSGPSPDRESRRDAPVDFFPPPPPLHSHSAHPRRPSTEVKKERKETSETLPPTVSKHSHSHRSPPHHAPSIPPPPPPPPPKRPSLDLPKERKETADPDAPLPPLPLHLHPPAPPKRPLLDMKKDKGKEKEKERKDSTDFKQQPKKPTLEGKKERKDTTDSKSSQGQQSRDSKPQRRDSSNSKSSSSPPAKKLSVERRDSHSSKSAHPGLLQRKMSTDSNDGRKSKPETPKTPTTPTSPMSPSFSSGSGPLSPRLLTGDS
78
364










Molecular Recognition Features






MoRF SequenceStartStop




1) LLDMKKDK
223
230