<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22219

Description Mediator complex subunit 14
SequenceMISAFLDQQAFLFVDTADRLASLARDALVHARLPSFAIPFAIDVLTTGSYPRLPTCIRDKIIPPDPITKAEKQTTLNQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDIPWRLLKLEILVEDKETGDGRALVHSMQVNYIHELVQSRLFADEKPLQDMYSCLHSFCLSLQLEVLHSQTLMLIRERWGDLVQVERYLPAKCLTLAVWNQQVLGRKTGTASVHKVSIKIDETDGSKPLQISHEPPLPACDSRLMERAMKIDHLSVEKLLIDSVHARSHQKLQELKAILKSSNPSDNSFIETALPTLVIPILEPCGRSECLHIFVDLHSGMFQPMLYGIDQSMLDDIEKTINDDMKRIVTWLQQLKFWLGEQRCRQSVKHLPTLCTDTLHLSNSASHPVGSLSKHRLFIKLTRLPQYYIVVEMFDVANSSTELQYKYYFLSVSQLEGEDGLPCALLLQQFKPNLEELVQDLSSGRMLRPGTKRKLSGEQGATEPKKPKRSGEMCAFNKELAHLVAMCDTNMPLIGLRSELSNMEIPHQGVQVEGDGCSHAIRLLRVPPAKGVSEETRKALDRTLLDCTFRLQGRNNRTWVAELVFTSCPLNSTSTKEQASTRHVYLTYENPLSEPVGGRKVVEMFLNDWNSISQLYECVLDFSRALPEMPSFLSLFSEIRLYNYRKLVLCYGNTKGSSVTIQWNSVTQRFHLALGTVGPNSGCSNCHNIILHQLQEMFNKTPNVVQLLQVLSDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSPTHIRLAFRNMYCIDIYCHSRGVVAIRDGAYSLFDNTKIVEGFYPAPGLKTFLSMFVDSNQDARRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWAASIPTILTHNALHVLLLPSPTMCVVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQLEQNLTIVNSNEPGVIMFKTEVLKCRVALNPKSYQTLQLKVTPENAGPWSQEELQVLEKFFETRVAGPPFKYNTLNAFTKLLGAPTNILRDCVRIMKLELFPEQAAQLKWNVQFCLTIPPSAPPIAPPGTIAVVLKTKMLFFLQLTQRLPVPQEPISIIVPIVYDMATGLTQQADIPRQHSSSGAAALMVSSILRRFNEHHPARPGECTIFASVHELMANLTLNSGGRP
Length1288
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.07
Grand average of hydropathy-0.179
Instability index50.94
Isoelectric point8.37
Molecular weight143686.47
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22219
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     327.87|     108|     210|     435|     551|       1
---------------------------------------------------------------------------
  435-  551 (159.74/110.15)	VVEMF.DVANSSTELqYKYyFLSVSQLEGEdgLPCAL.LLQQFK.PNLEELV.....QDLSSGRMLRPGTKRKLSGEQGATEpkkPKrSG.EMCaFNKELAHLVAMCDTNMPLIGLRSELSNMEIP
  646-  762 (168.13/89.07)	VVEMFlNDWNSISQL.YEC.VLDFSRALPE..MPSFLsLFSEIRlYNYRKLVlcygnTKGSSVTIQWNSVTQRFHLALGTVG...PN.SGcSNC.HNIILHQLQEMFNKTPNVVQLLQVLSDTQAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     216.11|      46|     210|     963|    1010|       2
---------------------------------------------------------------------------
  868-  900 (41.38/18.63)	..................PPSPV...GVDVMDTLM....PhmQPQQ...PIRGQGVYPPLT
  922-  954 (37.33/16.43)	PGalDPS..SPYPMVSPSQRTGTwpgSPQV...SG....P..SP.................
  963- 1010 (87.01/56.06)	PG..NPSlhSPIPDASHSPRAGT...SSQVMPTSM....P..PPRKL..PQRSWAASIPTI
 1178- 1220 (50.39/25.28)	P....PS..AP.PIA...PP.GT...IAVVLKTKMlfflQ..LTQRLpvPQEPISIIVP..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     246.18|      77|     149|     179|     263|       3
---------------------------------------------------------------------------
  179-  263 (121.56/107.86)	CLHSFCLSLQLEvLHSQTL..ML..IRERWGDlvQVERYLPAKCLTLAVWNQQV...LGRKTGTASVHKVSIKIDETdgskpLQISHEPPLP
  330-  413 (124.62/87.29)	CGRSECLHIFVD.LHSGMFqpMLygIDQSMLD..DIEKTINDDMKRIVTWLQQLkfwLGEQRCRQSVKHLPTLCTDT.....LHLSNSASHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     177.69|      57|     978|      78|     137|       4
---------------------------------------------------------------------------
   78-  137 (86.09/57.40)	QLNQILrhRLVTTDLPPQLA.NLTVANGRVKFRVEGEFEATLTVMGDDPDiPWRLLKLEIL
 1059- 1116 (91.60/51.25)	QLEQNL..TIVNSNEPGVIMfKTEVLKCRVALNPKSYQTLQLKVTPENAG.PWSQEELQVL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22219 with Med14 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) NQDARRRSVNEDDNPPSPVGVDVMDTLMPHMQPQQPIRGQGVYPPLTSPPNSYHGNVAPSPSMMPTQSPGALDPSSPYPMVSPSQRTGTWPGSPQVSGPSPGARIHGMSPGNPSLHSPIPDASHSPRAGTSSQVMPTSMPPPRKLPQRSWA
854
1004










Molecular Recognition Features






MoRF SequenceStartStop




NANANA