<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22216

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMDLAPDNDWRSPGFRQKVVAQIEEAMRKAGTAHAKTSNEMENHVFIKAKSREEYLSLVARLIIHFRDIHKKDQGGPGPMNALQTLNGVGGGGPNTIGMGPRPGAPMGGMAPMGQMPMGQHPLQGVGGIQQDNDWRFPGFRQKVVAQIEEAMRKAGTAHTKTSNEMETHVFIKAKSREEYLSLVARLIIHFRDIHKKAQGGPDPMNALQTLTGVGGGGPNTIGMGPRPGAPMGGMAPMGQMPMGQHPLQGVGGIQQAGTAGQMPMQMGSQQQPLQFQPFQAQQQAAMQPQQQTSMQSNSLQQQQFQQLQKLQMHQQQQQQQHQQQQQQHPNQPLQHQNQQQQAQAQAQAQAQQQQQQQQNQVSVNVSTNVIIMFSRTVRRT
Length380
PositionTail
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.04
Grand average of hydropathy-0.818
Instability index56.64
Isoelectric point10.13
Molecular weight41855.98
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP22216
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     136.94|      16|      16|      87|     102|       1
---------------------------------------------------------------------------
   87-  102 (36.55/12.20)	GVGGGGPNTIG...MGPRP
  103-  121 (31.92/ 9.86)	GAPMGGMAPMGqmpMGQHP
  212-  227 (36.55/12.20)	GVGGGGPNTIG...MGPRP
  228-  246 (31.92/ 9.86)	GAPMGGMAPMGqmpMGQHP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     356.82|      85|     123|       6|     128|       2
---------------------------------------------------------------------------
    6-   85 (155.10/61.54)	......................DNDWRSPGFRQKVVAQIEEAMRKAGTAHAKTSNEMENHVFIKAKSREEYLSLVARLIIHFRDIHKKDQGGPGPMNALQTL
  114-  210 (162.09/68.54)	QM.....PmgqhpLQgvggiqqDNDWRFPGFRQKVVAQIEEAMRKAGTAHTKTSNEMETHVFIKAKSREEYLSLVARLIIHFRDIHKKAQGGPDPMNALQTL
  265-  304 (39.63/10.42)	QMgsqqqP.....LQ............FQPFQ....AQQQAAMQPQQQTSMQ.SNSLQQQQF........................................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22216 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) IHKKDQGGPGPMNALQTLNGVGGGGPNTIGMGPRPGAPMGGMAPMGQMPMGQHPLQGVGGIQQD
2) MDLAPDNDWRSPGFRQKVVAQIEEAMRKAGTAHAKTSNEMENH
3) RDIHKKAQGGPDPMNALQTLTGVGGGGPNTIGMGPRPGAPMGGMAPMGQMPMGQHPLQGVGGIQQAGTAGQMPMQMGSQQQPLQFQPFQAQQQAAMQPQQQTSMQSNSLQQQQFQQLQKLQMHQQQQQQQHQQQQQQHPNQPLQHQNQQQQAQAQAQAQAQQQ
68
1
191
131
43
353










Molecular Recognition Features






MoRF SequenceStartStop




NANANA