<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP22215

Description Mediator of RNA polymerase II transcription subunit 4
SequenceMAAGERSTKEKLLSALSDMEVLSRELIEMLALSRTQKLPQPGEDTQVLELLVQRDKEFQELMQTAVEQGRIHQEMQQLEKEAEKRDSDIQLLQKQLKEAEHILATAVYQAKEKLKSIEKARKGSISSEEIIKYAHRISASNAVCAPLNWVPGDPRRPYPTDLEMRSGMLGHMSNLPTNGVNGHLPGDALAAGRLPDVLTPQYPWQSDVSMGMLPPHHGNDFGLEPPGHNKENEDDVEAMSTDSSSSSSDSD
Length251
PositionMiddle
OrganismAstyanax mexicanus (Blind cave fish) (Astyanax fasciatus mexicanus)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Actinopterygii> Neopterygii> Teleostei> Ostariophysi> Characiformes> Characoidei> Characidae> Astyanax.
Aromaticity0.03
Grand average of hydropathy-0.691
Instability index50.71
Isoelectric point5.04
Molecular weight27846.99
Publications
PubMed=25329095

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP22215
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.43|      14|      32|     140|     153|       1
---------------------------------------------------------------------------
  140-  153 (28.63/19.55)	SNAVCAPLN.WVPGD
  173-  187 (22.80/14.28)	SNLPTNGVNgHLPGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.84|      35|      38|      43|      80|       2
---------------------------------------------------------------------------
   36-   75 (44.36/35.50)	QKLPQpgE..DTQVlELLVQRDKEFQELMQTAVEQGRihQEM
   76-  114 (46.48/26.61)	QQLEKeaEkrDSDI.QLLQKQLKEAEHILATAVYQAK..EKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.46|      16|      43|     154|     171|       3
---------------------------------------------------------------------------
  154-  171 (29.28/23.84)	PRRPYPTDLEMrsGML.GH
  200-  216 (31.19/18.70)	PQYPWQSDVSM..GMLpPH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP22215 with Med4 domain of Kingdom Metazoa
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